10485 : 5-(4-chlorophenyl)-2-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole
Ligand Basic Message
| Ligand | Scaffold |
|---|---|
 |  |
| ID | 10485 |
| Name | 5-(4-chlorophenyl)-2-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole |
| smile | C1=CC(C2N(C(C3=C(F)C=C(F)C=C3F)=O)N=C(C3=CC=C(Cl)C=C3)S2)=C2C(OC(F)(F)O2)=C1 |
| weight | 513 |
| scaffold ID | 1377 |
| scaffold smile | O=C(c1ccccc1)N1N=C(c2ccccc2)SC1c1cccc2c1OCO2 |
Ligand Activities
| NR Protein | Protein Name | Ligand ID | Ligand Name | EC 50 |
|---|---|---|---|---|
| NR1H3 | Oxysterols receptor LXR-alpha | 10485 | 5-(4-chlorophenyl)-2-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole | 3.9 |
Scaffold Activities Statistic