3544 : 2-[2-methyl-4-({4-[2-(morpholin-4-yl)pyrimidin-5-yl]-5-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}methoxy)phenoxy]acetic acid
Ligand Basic Message
| Ligand | Scaffold |
|---|---|
 |  |
| ID | 3544 |
| Name | 2-[2-methyl-4-({4-[2-(morpholin-4-yl)pyrimidin-5-yl]-5-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}methoxy)phenoxy]acetic acid |
| smile | CC1=CC(=CC=C1OCC(O)=O)OCC1=NC(=C(C2=CC=C(C=C2)OC(F)(F)F)S1)C1=CN=C(N2CCOCC2)N=C1 |
| weight | 603 |
| scaffold ID | 381 |
| scaffold smile | c1ccc(OCc2nc(-c3cnc(N4CCOCC4)nc3)c(-c3ccccc3)s2)cc1 |
Ligand Activities
| NR Protein | Protein Name | Ligand ID | Ligand Name | EC 50 |
|---|---|---|---|---|
| NR1C1 | Peroxisome proliferator activated receptor alpha | 3544 | 2-[2-methyl-4-({4-[2-(morpholin-4-yl)pyrimidin-5-yl]-5-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}methoxy)phenoxy]acetic acid | 1.99 |
Scaffold Activities Statistic