4612 : 3-(4-{[2-amino-6-(4-{[3-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)pyrimidin-4-yl]oxy}phenyl)-2-methyl-2-phenoxypropanoic acid
Ligand Basic Message
| Ligand | Scaffold |
|---|---|
 |  |
| ID | 4612 |
| Name | 3-(4-{[2-amino-6-(4-{[3-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)pyrimidin-4-yl]oxy}phenyl)-2-methyl-2-phenoxypropanoic acid |
| smile | CC(C(O)=O)(OC1=CC=CC=C1)CC1=CC=C(C=C1)OC1=CC(N2CCN(CC2)CC2=CC=CC(C(F)(F)F)=C2)=NC(=N1)N |
| weight | 608 |
| scaffold ID | 213 |
| scaffold smile | c1ccc(CN2CCN(c3cc(Oc4ccc(CCOc5ccccc5)cc4)ncn3)CC2)cc1 |
Ligand Activities
| NR Protein | Protein Name | Ligand ID | Ligand Name | EC 50 |
|---|---|---|---|---|
| NR1C3 | Peroxisome proliferator activated receptor gamma | 4612 | 3-(4-{[2-amino-6-(4-{[3-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)pyrimidin-4-yl]oxy}phenyl)-2-methyl-2-phenoxypropanoic acid | 4.79 |
Scaffold Activities Statistic