Protein : NR1H3

Protein Basic Message
Protein
IDNR1H3
nameOxysterols receptor LXR-alpha
symbolLXR-a
pdbid3IPQ
uniprotQ13133
Protein-Ligand Activities Statistic
NR ProteinProtein NameLigand IDLigand NameEC 50
NR1H3Oxysterols receptor LXR-alpha10592(6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl)6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylate0.002
NR1H3Oxysterols receptor LXR-alpha10589(6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl)6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylate0.002
NR1H3Oxysterols receptor LXR-alpha10267N-[(2-chloro-6-fluorophenyl)methyl]-N-{[4-(3-methanesulfonylphenyl)phenyl]methyl}benzenesulfonamide0.006
NR1H3Oxysterols receptor LXR-alpha10409N-[(2-chloro-4-fluorophenyl)methyl]-N-{[4-(3-methanesulfonylphenyl)phenyl]methyl}benzenesulfonamide0.01
NR1H3Oxysterols receptor LXR-alpha10420N-[(2-chloro-6-fluorophenyl)methyl]-N-{[4-(3-methanesulfonylphenyl)phenyl]methyl}-2-methylbenzene-1-sulfonamide0.013
NR1H3Oxysterols receptor LXR-alpha10465N-(2,2,2-trifluoroethyl)-N-[4–(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)-phenyl]-benzenesulfonamide0.02
NR1H3Oxysterols receptor LXR-alpha103542-benzyl-3-[3-(3-methanesulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.02
NR1H3Oxysterols receptor LXR-alpha103583-({3-[3-(3-methanesulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl}methyl)-1,3-thiazolidine0.032
NR1H3Oxysterols receptor LXR-alpha78906-hydroxy-1,4a-dimethyl-N-[(1-phenylcyclohexyl)methyl]-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide0.05
NR1H3Oxysterols receptor LXR-alpha78931-(1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl)-4-phenylpiperidine0.07
NR1H3Oxysterols receptor LXR-alpha104832-(4-fluoro-2-methoxyphenyl)-5-(4-fluorophenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole0.07
NR1H3Oxysterols receptor LXR-alpha10245N-[(2-chloro-6-fluorophenyl)methyl]-N-{[4-(3-methanesulfonylphenyl)phenyl]methyl}-2,4,6-trimethylbenzene-1-sulfonamide0.079
NR1H3Oxysterols receptor LXR-alpha10431N-[(2-chloro-6-fluorophenyl)methyl]-N-{[4-(3-methanesulfonylphenyl)phenyl]methyl}-1-methyl-1H-imidazole-4-sulfonamide0.079
NR1H3Oxysterols receptor LXR-alpha10461(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol0.085
NR1H3Oxysterols receptor LXR-alpha10527methyl 1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-phenylpiperidine-2-carboxylate (anilinohexafluoroisopropanol 38)0.09
NR1H3Oxysterols receptor LXR-alpha10289N-[(2-chloro-6-fluorophenyl)methyl]-N-{[4-(3-methanesulfonylphenyl)phenyl]methyl}cyclopropanesulfonamide0.1
NR1H3Oxysterols receptor LXR-alpha10466N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)-phenyl]-benzenesulfonamide0.1
NR1H3Oxysterols receptor LXR-alpha105002-[4-[benzyl(2,2,2-trifluoroethyl)amino]-3-chlorophenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 7)0.1
NR1H3Oxysterols receptor LXR-alpha105142-[3-chloro-4-[ethyl-[[5-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methyl]amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 21)0.1
NR1H3Oxysterols receptor LXR-alpha10522methyl 2-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylpropanoate (anilinohexafluoroisopropanol 33)0.1
NR1H3Oxysterols receptor LXR-alpha104112-[4-({[3-(3-benzyl-8-chloroquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid0.121
NR1H3Oxysterols receptor LXR-alpha10278N-[(2-chloro-4-fluorophenyl)methyl]-N-{[4-(3-methanesulfonylphenyl)phenyl]methyl}-2,4,6-trimethylbenzene-1-sulfonamide0.126
NR1H3Oxysterols receptor LXR-alpha7921N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide0.135
NR1H3Oxysterols receptor LXR-alpha7883N-[1-(adamantan-1-yl)ethyl]-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide0.14
NR1H3Oxysterols receptor LXR-alpha78951-(1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl)-3-phenylpiperidine0.15
NR1H3Oxysterols receptor LXR-alpha7897N-(1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl)-1-phenylcyclohexane-1-carboxamide0.17
NR1H3Oxysterols receptor LXR-alpha105812-[2-chloro-4-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acid0.17
NR1H3Oxysterols receptor LXR-alpha104825-(4-chlorophenyl)-2-(2-methoxyphenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole0.18
NR1H3Oxysterols receptor LXR-alpha105752-[2-oxo-1-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]-3H-indol-5-yl]acetic acid0.18
NR1H3Oxysterols receptor LXR-alpha104672-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid0.19
NR1H3Oxysterols receptor LXR-alpha105022-[4-[benzyl(ethyl)amino]-3-chlorophenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 9)0.2
NR1H3Oxysterols receptor LXR-alpha105102-[4-[[2-(3-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl-ethylamino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 17)0.2
NR1H3Oxysterols receptor LXR-alpha105132-[4-[ethyl-[[5-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methyl]amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 20)0.2
NR1H3Oxysterols receptor LXR-alpha10526methyl 1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-phenylpyrrolidine-2-carboxylate (anilinohexafluoroisopropanol 37)0.2
NR1H3Oxysterols receptor LXR-alpha103571-({3-[3-(3-methanesulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl}methyl)piperidine0.204
NR1H3Oxysterols receptor LXR-alpha7886N-(adamantan-1-yl)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide0.22
NR1H3Oxysterols receptor LXR-alpha104953-[4-(1-benzoylindol-2-yl)phenyl]propanenitrile (benzamide derivative 8)0.22
NR1H3Oxysterols receptor LXR-alpha79092-(4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenoxymethyl}phenyl)acetic acid0.24
NR1H3Oxysterols receptor LXR-alpha105112-[3-chloro-4-[[2-(3-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl-ethylamino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 18)0.3
NR1H3Oxysterols receptor LXR-alpha10523methyl 2-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylbutanoate (anilinohexafluoroisopropanol 34)0.3
NR1H3Oxysterols receptor LXR-alpha78898-(dodecahydro-1H-carbazole-9-carbonyl)-4b,8-dimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-3-ol0.32
NR1H3Oxysterols receptor LXR-alpha104353-benzyl-4-{3-[3-(morpholine-4-carbonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline0.345
NR1H3Oxysterols receptor LXR-alpha104795-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole0.346
NR1H3Oxysterols receptor LXR-alpha7892N-(2,2-diphenylpropyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide0.36
NR1H3Oxysterols receptor LXR-alpha79435-[(benzenesulfonyl)({7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl})fluoromethyl]-N,N-dimethyl-1,2,4-oxadiazol-3-amine0.37
NR1H3Oxysterols receptor LXR-alpha104863-[5-(4-fluorophenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazol-2-yl]-2-methoxypyridine0.4
NR1H3Oxysterols receptor LXR-alpha105252-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-N,N-dimethyl-2-phenylpropanamide (anilinohexafluoroisopropanol 36)0.4
NR1H3Oxysterols receptor LXR-alpha105302-[3-chloro-4-[ethyl-(2-hydroxy-1-phenylethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 44)0.4
NR1H3Oxysterols receptor LXR-alpha103502-ethyl-3-[3-(3-methanesulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.42
NR1H3Oxysterols receptor LXR-alpha78941'-(1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl)spiro[indene-1,4'-piperidine]0.43
NR1H3Oxysterols receptor LXR-alpha79402-[(benzenesulfonyl)({7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl})fluoromethyl]-5-cyclopropyl-1,3,4-oxadiazole0.43
NR1H3Oxysterols receptor LXR-alpha102313-benzyl-4-{3-[3-(pyrrolidine-1-carbonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline0.435
NR1H3Oxysterols receptor LXR-alpha105632-[4-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acid0.45
NR1H3Oxysterols receptor LXR-alpha104052-[4-({[3-(3-benzyl-8-methylquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid0.467
NR1H3Oxysterols receptor LXR-alpha104363-benzyl-4-{3-[3-(piperidine-1-carbonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline0.477
NR1H3Oxysterols receptor LXR-alpha105732-[1-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]indazol-5-yl]acetic acid0.48
NR1H3Oxysterols receptor LXR-alpha105042-[3-chloro-4-[ethyl(1,3-thiazol-4-ylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 11)0.5
NR1H3Oxysterols receptor LXR-alpha10524methyl 2-[2-chloro-N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylbutanoate (anilinohexafluoroisopropanol 35)0.5
NR1H3Oxysterols receptor LXR-alpha103263-{3-[8-chloro-2-(propan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenoxy}-N-methylbenzene-1-sulfonamide0.53
NR1H3Oxysterols receptor LXR-alpha103378-chloro-3-[3-(3-methanesulfonylphenoxy)phenyl]-2-(propan-2-yl)imidazo[1,2-a]pyridine0.54
NR1H3Oxysterols receptor LXR-alpha105852-[5-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]pyrazin-2-yl]acetic acid0.54
NR1H3Oxysterols receptor LXR-alpha103533-[3-(3-methanesulfonylphenoxy)phenyl]-2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.57
NR1H3Oxysterols receptor LXR-alpha105712-[1-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]indol-5-yl]acetic acid0.59
NR1H3Oxysterols receptor LXR-alpha104785-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole0.608
NR1H3Oxysterols receptor LXR-alpha105862-[2-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]pyrimidin-5-yl]acetic acid0.62
NR1H3Oxysterols receptor LXR-alpha102323-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}-N,N-diethylbenzamide0.675
NR1H3Oxysterols receptor LXR-alpha103273-{3-[3-(ethanesulfonyl)phenoxy]phenyl}-2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.68
NR1H3Oxysterols receptor LXR-alpha79152-{5-[({3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}methyl)amino]naphthalen-1-yl}acetic acid0.685
NR1H3Oxysterols receptor LXR-alpha103332-methyl-3-{3-[3-(propane-2-sulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.7
NR1H3Oxysterols receptor LXR-alpha104932-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-(2,4,5-trifluoro-3-methoxybenzoyl)-2,3-dihydro-1,3,4-thiadiazole0.7
NR1H3Oxysterols receptor LXR-alpha105052-[4-[ethyl(pyridin-2-ylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 12)0.7
NR1H3Oxysterols receptor LXR-alpha105151,1,1,3,3,3-hexafluoro-2-[4-[[5-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methyl-(2,2,2-trifluoroethyl)amino]phenyl]propan-2-ol (anilinohexafluoroisopropanol 22)0.7
NR1H3Oxysterols receptor LXR-alpha10538methyl 4-[2-[2-chloro-N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]benzoate (anilinohexafluoroisopropanol 52)0.7
NR1H3Oxysterols receptor LXR-alpha103522-tert-butyl-3-[3-(3-methanesulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.71
NR1H3Oxysterols receptor LXR-alpha79382-[(benzenesulfonyl)({7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl})fluoromethyl]-1,3,4-oxadiazole0.77
NR1H3Oxysterols receptor LXR-alpha105092-[3-chloro-4-[ethyl(2-phenylethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 16)0.8
NR1H3Oxysterols receptor LXR-alpha105372-[2-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]-N,N-dimethylacetamide (anilinohexafluoroisopropanol 51)0.8
NR1H3Oxysterols receptor LXR-alpha105773-[1-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]indol-5-yl]propanoic acid0.82
NR1H3Oxysterols receptor LXR-alpha7930methyl 2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-(3-chlorobenzenesulfonyl)-2-fluoroacetate0.84
NR1H3Oxysterols receptor LXR-alpha103443-[3-(3-methanesulfonylphenoxy)phenyl]-2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.84
NR1H3Oxysterols receptor LXR-alpha7932methyl 2-(3-bromobenzenesulfonyl)-2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-fluoroacetate0.85
NR1H3Oxysterols receptor LXR-alpha103491-{3-[3-(3-methanesulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl}-1H-imidazole0.85
NR1H3Oxysterols receptor LXR-alpha79415-[(benzenesulfonyl)({7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl})fluoromethyl]-N,N-dimethyl-1,3,4-oxadiazol-2-amine0.89
NR1H3Oxysterols receptor LXR-alpha103253-{3-[8-chloro-2-(propan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenoxy}-N-[(4-methoxyphenyl)methyl]-N-methylbenzene-1-sulfonamide0.89
NR1H3Oxysterols receptor LXR-alpha104913-(2,6-difluoro-4-methoxybenzoyl)-2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-2,3-dihydro-1,3,4-thiadiazole0.9
NR1H3Oxysterols receptor LXR-alpha104923-(4-bromo-2,6-difluorobenzoyl)-2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-2,3-dihydro-1,3,4-thiadiazole0.9
NR1H3Oxysterols receptor LXR-alpha104992-[4-[benzyl(2,2,2-trifluoroethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 6)0.9
NR1H3Oxysterols receptor LXR-alpha105312-[4-[ethyl-(2-methoxy-1-phenylethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 45)0.9
NR1H3Oxysterols receptor LXR-alpha1039414-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-methyl-2-azatricyclo[10.4.0.0?,?]hexadeca-1(16),4,6,8,12,14-hexaen-3-one0.91
NR1H3Oxysterols receptor LXR-alpha103513-[3-(3-methanesulfonylphenoxy)phenyl]-2-(propan-2-yl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine0.95
NR1H3Oxysterols receptor LXR-alpha105082-[4-[ethyl(2-phenylethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 15)1.0
NR1H3Oxysterols receptor LXR-alpha105122-[4-[[2-(3-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl-(2,2,2-trifluoroethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 19)1.0
NR1H3Oxysterols receptor LXR-alpha105282-[4-[ethyl-(2-hydroxy-2-phenylethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 42)1.0
NR1H3Oxysterols receptor LXR-alpha7929methyl 2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-fluoro-2-(3-methoxybenzenesulfonyl)acetate1.07
NR1H3Oxysterols receptor LXR-alpha7933methyl 2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-fluoro-2-(pyridine-3-sulfonyl)acetate1.07
NR1H3Oxysterols receptor LXR-alpha79425-[(benzenesulfonyl)({7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl})fluoromethyl]-3-methyl-1,2,4-oxadiazole1.09
NR1H3Oxysterols receptor LXR-alpha105012-[4-[benzyl(ethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 8)1.1
NR1H3Oxysterols receptor LXR-alpha10539methyl 2-[4-[2-[2-chloro-N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]phenyl]acetate (anilinohexafluoroisopropanol 53)1.1
NR1H3Oxysterols receptor LXR-alpha105842-[2-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]-1,3-thiazol-5-yl]acetic acid1.1
NR1H3Oxysterols receptor LXR-alpha10498tert-butyl 2-[4-(3-amino-3-oxopropyl)phenyl]indole-1-carboxylate (Boc-indole derivate 26)1.11
NR1H3Oxysterols receptor LXR-alpha104973-[4-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-2-yl]phenyl]propanoic acid (Boc-indole derivate 25)1.15
NR1H3Oxysterols receptor LXR-alpha79202-{5-[({3-[8-(trifluoromethyl)quinolin-4-yl]phenyl}methyl)amino]naphthalen-1-yl}acetic acid1.18
NR1H3Oxysterols receptor LXR-alpha10496tert-butyl 2-[4-(2-cyanoethyl)phenyl]indole-1-carboxylate (Boc-indole derivate 22)1.19
NR1H3Oxysterols receptor LXR-alpha102038-chloro-3-methyl-4-{3-[3-(morpholine-4-carbonyl)phenoxy]phenyl}quinoline1.237
NR1H3Oxysterols receptor LXR-alpha105802-[2-methyl-4-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acid1.3
NR1H3Oxysterols receptor LXR-alpha7931methyl 2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-fluoro-2-(3-fluorobenzenesulfonyl)acetate1.35
NR1H3Oxysterols receptor LXR-alpha79392-[(benzenesulfonyl)({7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl})fluoromethyl]-5-methyl-1,3,4-oxadiazole1.35
NR1H3Oxysterols receptor LXR-alpha7928methyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-fluoro-2-(3-fluorobenzenesulfonyl)acetate1.39
NR1H3Oxysterols receptor LXR-alpha104802-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole1.4
NR1H3Oxysterols receptor LXR-alpha104812-(2,3-dimethoxyphenyl)-5-(4-methylphenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole1.4
NR1H3Oxysterols receptor LXR-alpha10540methyl 3-[4-[2-[2-chloro-N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]phenyl]propanoate (anilinohexafluoroisopropanol 54)1.4
NR1H3Oxysterols receptor LXR-alpha103393-(3-{3-[2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]phenoxy}benzenesulfonyl)propan-1-ol1.42
NR1H3Oxysterols receptor LXR-alpha104885-(3,4-difluorophenyl)-2-(2,3-dimethoxyphenyl)-3-(3-fluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole1.5
NR1H3Oxysterols receptor LXR-alpha10494tert-butyl 2-[2-(benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]indole-1-carboxylate (Indan derivative 1)1.5
NR1H3Oxysterols receptor LXR-alpha79362-(benzenesulfonyl)-2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-fluoro-N-methylacetamide1.55
NR1H3Oxysterols receptor LXR-alpha103482-ethyl-3-{3-[(3-methanesulfonylphenyl)methyl]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine1.57
NR1H3Oxysterols receptor LXR-alpha10463(3S,8S,9S,10R,13S,14S,17S)-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol1.6
NR1H3Oxysterols receptor LXR-alpha102383-[3-(8-chloro-3-methylquinolin-4-yl)phenoxy]-N-propylbenzamide1.633
NR1H3Oxysterols receptor LXR-alpha103293-[3-(3-methanesulfonylphenoxy)phenyl]-2-(propan-2-yl)imidazo[1,2-a]pyridine-8-carbonitrile1.68
NR1H3Oxysterols receptor LXR-alpha103955-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methyl-2-methylidene-9-azatricyclo[9.4.0.0³,?]pentadeca-1(15),3,5,7,11,13-hexaen-10-one1.7
NR1H3Oxysterols receptor LXR-alpha102372-[(2,4-dimethylphenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole1.81
NR1H3Oxysterols receptor LXR-alpha104842-[2-(difluoromethoxy)phenyl]-5-(4-fluorophenyl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole1.9
NR1H3Oxysterols receptor LXR-alpha105292-[4-[ethyl-(2-hydroxy-1-phenylethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 43)1.9
NR1H3Oxysterols receptor LXR-alpha105322-[4-[ethyl-(1-phenyl-2-phenylmethoxyethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 46)1.9
NR1H3Oxysterols receptor LXR-alpha105781-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]indole-5-carboxylic acid1.9
NR1H3Oxysterols receptor LXR-alpha10458(4R)-4-[(3S,10R,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-N,N-dimethylpentanamide2.0
NR1H3Oxysterols receptor LXR-alpha7925methyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-(2-chlorobenzenesulfonyl)propanoate2.08
NR1H3Oxysterols receptor LXR-alpha104893-(3,5-difluorobenzoyl)-2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-2,3-dihydro-1,3,4-thiadiazole2.1
NR1H3Oxysterols receptor LXR-alpha105072-[4-[ethyl(pyridin-4-ylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 14)2.1
NR1H3Oxysterols receptor LXR-alpha102043-[3-(8-chloro-3-methylquinolin-4-yl)phenoxy]-N-ethylbenzamide2.102
NR1H3Oxysterols receptor LXR-alpha7927methyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-(3-chlorobenzenesulfonyl)-2-fluoroacetate2.17
NR1H3Oxysterols receptor LXR-alpha7924methyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-(3-chlorobenzenesulfonyl)propanoate2.18
NR1H3Oxysterols receptor LXR-alpha105202-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenyl-1-piperidin-1-ylethanone (anilinohexafluoroisopropanol 31)2.2
NR1H3Oxysterols receptor LXR-alpha10533methyl 2-[2-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]acetate (anilinohexafluoroisopropanol 47)2.2
NR1H3Oxysterols receptor LXR-alpha7926methyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-(2-methoxybenzenesulfonyl)propanoate2.3
NR1H3Oxysterols receptor LXR-alpha10516methyl 2-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylacetate (anilinohexafluoroisopropanol 27)2.3
NR1H3Oxysterols receptor LXR-alpha105742-[1-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]benzotriazol-5-yl]acetic acid2.3
NR1H3Oxysterols receptor LXR-alpha104902-(2,3-dimethoxyphenyl)-3-(5-fluoro-2-methylbenzoyl)-5-(4-fluorophenyl)-2,3-dihydro-1,3,4-thiadiazole2.4
NR1H3Oxysterols receptor LXR-alpha105682-[3-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acid2.6
NR1H3Oxysterols receptor LXR-alpha102093-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}-N-propylbenzamide2.709
NR1H3Oxysterols receptor LXR-alpha7934methyl 2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-fluoro-2-(pyridine-2-sulfonyl)acetate2.75
NR1H3Oxysterols receptor LXR-alpha102224-({butyl[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]amino}methyl)-2,6-dichlorophenol3.0
NR1H3Oxysterols receptor LXR-alpha105762-oxo-1-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]-3H-indole-5-carboxylic acid3.0
NR1H3Oxysterols receptor LXR-alpha7899N-{bicyclo[2.2.1]heptan-2-yl}-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide3.1
NR1H3Oxysterols receptor LXR-alpha103353-{3-[(3-methanesulfonylphenyl)methoxy]phenyl}-2-(propan-2-yl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine3.24
NR1H3Oxysterols receptor LXR-alpha105032-[4-[ethyl(1,3-thiazol-4-ylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 10)3.3
NR1H3Oxysterols receptor LXR-alpha10460(3S,5R,10S,13R,17R)-4,4,10,13-tetramethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol3.5
NR1H3Oxysterols receptor LXR-alpha10462(3S,7R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol3.5
NR1H3Oxysterols receptor LXR-alpha105822-[4-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]-2-(trifluoromethyl)phenyl]acetic acid3.6
NR1H3Oxysterols receptor LXR-alpha105414-[2-[2-chloro-N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]benzoic acid (anilinohexafluoroisopropanol 55)3.7
NR1H3Oxysterols receptor LXR-alpha104855-(4-chlorophenyl)-2-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-3-(2,4,6-trifluorobenzoyl)-2,3-dihydro-1,3,4-thiadiazole3.9
NR1H3Oxysterols receptor LXR-alpha103935-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methyl-2-oxa-9-azatricyclo[9.4.0.0³,?]pentadeca-1(15),3,5,7,11,13-hexaen-10-one4.2
NR1H3Oxysterols receptor LXR-alpha7935methyl 2-(benzenesulfonyl)-2-{7-chloro-1H,2H,3H,4H-cyclopenta[b]indol-2-yl}-2-fluoroacetate4.23
NR1H3Oxysterols receptor LXR-alpha102062-benzyl-3-phenyl-7-(trifluoromethyl)-2H-indazole4.27
NR1H3Oxysterols receptor LXR-alpha105062-[4-[ethyl(pyridin-3-ylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 13)4.3
NR1H3Oxysterols receptor LXR-alpha105433-[4-[2-[2-chloro-N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]phenyl]propanoic acid (anilinohexafluoroisopropanol 57)4.5
NR1H3Oxysterols receptor LXR-alpha10448(3S,8S,9S,10R,13S,14S,17R)-17-[(2S,3R)-3-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol5.0
NR1H3Oxysterols receptor LXR-alpha105832-[6-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]pyridin-3-yl]acetic acid5.0
NR1H3Oxysterols receptor LXR-alpha102332-[(2-chlorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole5.02
NR1H3Oxysterols receptor LXR-alpha105422-[4-[2-[2-chloro-N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]phenyl]acetic acid (anilinohexafluoroisopropanol 56)5.5
NR1H3Oxysterols receptor LXR-alpha7923methyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-(3,4-dichlorobenzenesulfonyl)propanoate5.8
NR1H3Oxysterols receptor LXR-alpha7922methyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-(4-fluorobenzenesulfonyl)propanoate5.81
NR1H3Oxysterols receptor LXR-alpha105582-[3-chloro-4-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propylsulfanyl]phenyl]acetic acid5.9
NR1H3Oxysterols receptor LXR-alpha102523-(3-benzyl-8-chlorocinnolin-4-yl)-N-[(1-methyl-1H-indol-2-yl)methyl]aniline6.0
NR1H3Oxysterols receptor LXR-alpha10570N-methyl-N-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]aniline6.0
NR1H3Oxysterols receptor LXR-alpha104383-(4-fluorophenyl)-2-[(2-fluorophenyl)methyl]-7-(trifluoromethyl)-2H-indazole6.1
NR1H3Oxysterols receptor LXR-alpha104875-(4-chlorophenyl)-3-(2,4-difluorobenzoyl)-2-(2,3-dimethoxyphenyl)-2,3-dihydro-1,3,4-thiadiazole6.7
NR1H3Oxysterols receptor LXR-alpha10447(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol7.0
NR1H3Oxysterols receptor LXR-alpha10456(1S,2R,5S,7R,9S,11S,12S,15R,16R)-15-[(2R)-4-[(2S)-3,3-dimethyloxiran-2-yl]butan-2-yl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.0^{2,7}.0^{7,9}.0^{12,16}]octadecan-5-ol7.0
NR1H3Oxysterols receptor LXR-alpha79192-{5-[({3-[3-methyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}methyl)amino]naphthalen-1-yl}acetic acid7.86
NR1H3Oxysterols receptor LXR-alpha10452(3S,7S,8S,9S,10R,13R,14S,17R)-17-[(2R)-4-[(2S)-3,3-dimethyloxiran-2-yl]butan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol8.0
NR1H3Oxysterols receptor LXR-alpha10457methyl 4-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate8.0
NR1H3Oxysterols receptor LXR-alpha105642-[4-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propylamino]phenyl]acetic acid8.0
NR1H3Oxysterols receptor LXR-alpha102613-benzyl-4-{3-[(1-methyl-1H-indol-7-yl)methoxy]phenyl}-8-(trifluoromethyl)cinnoline8.32
NR1H3Oxysterols receptor LXR-alpha102353-(4-fluorophenyl)-2-[(4-fluorophenyl)methyl]-7-(trifluoromethyl)-2H-indazole8.4
NR1H3Oxysterols receptor LXR-alpha102513-benzyl-4-(3-{[5-fluoro-2-(trifluoromethyl)phenyl]methoxy}phenyl)-8-(trifluoromethyl)cinnoline8.41
NR1H3Oxysterols receptor LXR-alpha105212-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-1-morpholin-4-yl-2-phenylethanone (anilinohexafluoroisopropanol 32)8.5
NR1H3Oxysterols receptor LXR-alpha105192-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-N,N-dimethyl-2-phenylacetamide (anilinohexafluoroisopropanol 30)9.3
NR1H3Oxysterols receptor LXR-alpha105172-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylacetic acid (anilinohexafluoroisopropanol 28)9.4
NR1H3Oxysterols receptor LXR-alpha10443(1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-4-[(2R)-3,3-dimethyloxiran-2-yl]butan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol10.0
NR1H3Oxysterols receptor LXR-alpha105352-[2-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]acetic acid (anilinohexafluoroisopropanol 49)10.0
NR1H3Oxysterols receptor LXR-alpha105182-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-N-methyl-2-phenylacetamide (anilinohexafluoroisopropanol 29)10.9
NR1H3Oxysterols receptor LXR-alpha102493-(3-benzyl-8-chlorocinnolin-4-yl)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}aniline11.1
NR1H3Oxysterols receptor LXR-alpha102663-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]-N-[(1-methyl-1H-indol-7-yl)methyl]aniline12.0
NR1H3Oxysterols receptor LXR-alpha104392-[(4-chlorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole12.77
NR1H3Oxysterols receptor LXR-alpha102112-[(4-chloro-2-fluorophenyl)methyl]-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole13.28
NR1H3Oxysterols receptor LXR-alpha102393-(4-chlorophenyl)-2-[(2-fluorophenyl)methyl]-7-(trifluoromethyl)-2H-indazole13.44
NR1H3Oxysterols receptor LXR-alpha102573-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]-N-[(1-methyl-1H-indol-2-yl)methyl]aniline13.5
NR1H3Oxysterols receptor LXR-alpha102402-[(2-chloro-4-fluorophenyl)methyl]-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole14.4
NR1H3Oxysterols receptor LXR-alpha102133-(4-chlorophenyl)-2-[(2-chlorophenyl)methyl]-7-(trifluoromethyl)-2H-indazole15.21
NR1H3Oxysterols receptor LXR-alpha102533-benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluoromethyl)phenyl]methoxy}phenyl)cinnoline15.3
NR1H3Oxysterols receptor LXR-alpha102103-(4-chlorophenyl)-7-(trifluoromethyl)-2-{[2-(trifluoromethyl)phenyl]methyl}-2H-indazole15.83
NR1H3Oxysterols receptor LXR-alpha102693-benzyl-4-(3-{[2-chloro-3-(trifluoromethyl)phenyl]methoxy}phenyl)-8-(trifluoromethyl)cinnoline18.1
NR1H3Oxysterols receptor LXR-alpha105342-[4-[ethyl-[2-(2-hydroxyethoxy)-1-phenylethyl]amino]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol (anilinohexafluoroisopropanol 48)40.0
NR1H3Oxysterols receptor LXR-alpha105362-[2-[N-ethyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]-2-phenylethoxy]-N-methylacetamide (anilinohexafluoroisopropanol 50)40.0
NR1H3Oxysterols receptor LXR-alpha78981-(1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)-3-(adamantan-1-yl)propane-1,3-dione50.0
NR1H3Oxysterols receptor LXR-alpha10588(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid50.0

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