HIT-result

Type	Detail
Target ID	T04AY9
Protein Name	Secreted frizzled-related protein 1
Uniprot ID	Q8N474
Protein Name Alias	FRP-1; sFRP-1; Secreted apoptosis-related protein 2; SARP-2
Gene ID	6422
Gene Symbol	SFRP1
Gene Alias	FRP; FRP1; SARP2
TTD	NA
Pfam	PF01392 ; PF01759
GO	0050732:negative regulation of peptidyl-tyrosine phosphorylation 0044345:stromal-epithelial cell signaling involved in prostate gland development 0043547:positive regulation of GTPase activity 0010975:regulation of neuron projection development 0046676:negative regulation of insulin secretion 0008284:positive regulation of cell population proliferation 0046851:negative regulation of bone remodeling 0008285:negative regulation of cell population proliferation 0030279:negative regulation of ossification 0071356:cellular response to tumor necrosis factor 0050680:negative regulation of epithelial cell proliferation 0030308:negative regulation of cell growth 0010629:negative regulation of gene expression 0030514:negative regulation of BMP signaling pathway 0071363:cellular response to growth factor stimulus 0005576:extracellular region 0060527:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis 0090179:planar cell polarity pathway involved in neural tube closure 0010564:regulation of cell cycle process 0051894:positive regulation of focal adhesion assembly 0071305:cellular response to vitamin D 0071392:cellular response to estradiol stimulus 0043066:negative regulation of apoptotic process 0048147:negative regulation of fibroblast proliferation 0042802:identical protein binding 0071504:cellular response to heparin 0060218:hematopoietic stem cell differentiation 0062023:collagen-containing extracellular matrix 0005829:cytosol 0071456:cellular response to hypoxia 0051496:positive regulation of stress fiber assembly 0071481:cellular response to X-ray 0001657:ureteric bud development 0045880:positive regulation of smoothened signaling pathway 0005615:extracellular space 0044344:cellular response to fibroblast growth factor stimulus 0060766:negative regulation of androgen receptor signaling pathway 2000052:positive regulation of non-canonical Wnt signaling pathway 2000270:negative regulation of fibroblast apoptotic process 0071380:cellular response to prostaglandin E stimulus 0071773:cellular response to BMP stimulus 0001954:positive regulation of cell-matrix adhesion 0001649:osteoblast differentiation 0014034:neural crest cell fate commitment 0090090:negative regulation of canonical Wnt signaling pathway 2000041:negative regulation of planar cell polarity pathway involved in axis elongation 0017147:Wnt-protein binding 0033689:negative regulation of osteoblast proliferation 0008585:female gonad development 2000271:positive regulation of fibroblast apoptotic process 0030336:negative regulation of cell migration 0045765:regulation of angiogenesis 0014070:response to organic cyclic compound 0009950:dorsal/ventral axis specification 0050679:positive regulation of epithelial cell proliferation 0045600:positive regulation of fat cell differentiation 0045671:negative regulation of osteoclast differentiation 0030178:negative regulation of Wnt signaling pathway 0042493:response to drug 2000054:negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification 0009986:cell surface 0045893:positive regulation of transcription, DNA-templated 0002244:hematopoietic progenitor cell differentiation 0060346:bone trabecula formation 0043508:negative regulation of JUN kinase activity 0010719:negative regulation of epithelial to mesenchymal transition 0005109:frizzled binding 0070062:extracellular exosome 0071347:cellular response to interleukin-1 0045578:negative regulation of B cell differentiation 1904956:regulation of midbrain dopaminergic neuron differentiation 0004197:cysteine-type endopeptidase activity 0035019:somatic stem cell population maintenance 0090244:Wnt signaling pathway involved in somitogenesis 0071560:cellular response to transforming growth factor beta stimulus 0071542:dopaminergic neuron differentiation 0045892:negative regulation of transcription, DNA-templated 0060687:regulation of branching involved in prostate gland morphogenesis 2000080:negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation 0060070:canonical Wnt signaling pathway 0008201:heparin binding 0005886:plasma membrane 0048546:digestive tract morphogenesis 0090246:convergent extension involved in somitogenesis 0008584:male gonad development 0045668:negative regulation of osteoblast differentiation 0043065:positive regulation of apoptotic process 0071391:cellular response to estrogen stimulus 0030307:positive regulation of cell growth 0030177:positive regulation of Wnt signaling pathway 1902043:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 0090263:positive regulation of canonical Wnt signaling pathway 0009267:cellular response to starvation
PDB	NA
Drugbank	NA
KEGG	hsa:6422

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Name: Amarogentin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1245	Bai Qian	白前	Cynanchum root	Cynanchum stauntonii
H0961	Dang Yao	当药	Chinese swertia	Swertia chinensis
H0162	Long Dan	龙胆	Rough gentian	Gentiana scabra