HIT-result

Type	Detail
Target ID	T11FY2
Protein Name	Voltage-dependent anion-selective channel protein 1
Uniprot ID	P21796
Protein Name Alias	VDAC-1; hVDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM
Gene ID	7416
Gene Symbol	VDAC1
Gene Alias	VDAC
TTD	T99397: Clinical Trial target
Pfam	PF01459
GO	0042645:mitochondrial nucleoid 0110099:negative regulation of calcium import into the mitochondrion 0008308:voltage-gated anion channel activity 0043066:negative regulation of apoptotic process 1903146:regulation of autophagy of mitochondrion 0016020:membrane 1901526:positive regulation of mitophagy 0046930:pore complex 0007612:learning 0031210:phosphatidylcholine binding 0007270:neuron-neuron synaptic transmission 0042802:identical protein binding 0044877:protein-containing complex binding 0006915:apoptotic process 0005886:plasma membrane 0001662:behavioral fear response 0006820:anion transport 0016236:macroautophagy 0006090:pyruvate metabolic process 0006851:mitochondrial calcium ion transmembrane transport 0044325:ion channel binding 0030855:epithelial cell differentiation 0005739:mitochondrion 0005741:mitochondrial outer membrane 0015485:cholesterol binding 2000378:negative regulation of reactive oxygen species metabolic process 0005634:nucleus 0019901:protein kinase binding 0045121:membrane raft 0031966:mitochondrial membrane 0005757:mitochondrial permeability transition pore complex 0097001:ceramide binding 0070062:extracellular exosome 0015288:porin activity 0016032:viral process 0008021:synaptic vesicle
PDB	5XDN ; 2K4T ; 6G73 ; 5JDP ; 5XDO ; 2JK4 ; 6TIQ ; 6G6U ; 6TIR
Drugbank	DB14011 ; DB14009 ; DB01375 ; DB09061
KEGG	hsa:7416

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 1)