HIT-result

Type	Detail
Target ID	T15YX5
Protein Name	Thyrotropin receptor
Uniprot ID	P16473
Protein Name Alias	Thyroid-stimulating hormone receptor; TSH-R
Gene ID	7253
Gene Symbol	TSHR
Gene Alias	LGR3
TTD	T60606: Successful target
Pfam	PF13306 ; PF00001
GO	0008528:G protein-coupled peptide receptor activity 1905229:cellular response to thyrotropin-releasing hormone 0038194:thyroid-stimulating hormone signaling pathway 0009986:cell surface 0120162:positive regulation of cold-induced thermogenesis 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0002862:negative regulation of inflammatory response to antigenic stimulus 0038023:signaling receptor activity 0007186:G protein-coupled receptor signaling pathway 0009755:hormone-mediated signaling pathway 0016323:basolateral plasma membrane 0044877:protein-containing complex binding 0007166:cell surface receptor signaling pathway 0007267:cell-cell signaling 0005886:plasma membrane 0005887:integral component of plasma membrane 1904588:cellular response to glycoprotein 0043235:receptor complex 0008284:positive regulation of cell population proliferation 0007190:activation of adenylate cyclase activity 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0004996:thyroid-stimulating hormone receptor activity
PDB	1XUM ; 3G04 ; 2XWT
Drugbank	DB00024
KEGG	hsa:7253

Target Description