Target Description

Type Detail
Target ID T18SEF
Protein Name Transitional endoplasmic reticulum ATPase
Uniprot ID P55072
Protein Name Alias TER ATPase;  EC;  15S Mg(2+)-ATPase p97 subunit;  Valosin-containing protein;  VCP
Gene ID 7415
Gene Symbol VCP
Gene Alias NA
TTD T12646: Clinical Trial target
Pfam PF09336 ; PF02359 ; PF17862 ; PF00004 ; PF02933
0045184:establishment of protein localization

0032991:protein-containing complex

0006974:cellular response to DNA damage stimulus

0030970:retrograde protein transport, ER to cytosol

0006457:protein folding

0019903:protein phosphatase binding

0032510:endosome to lysosome transport via multivesicular body sorting pathway

1990730:VCP-NSFL1C complex

0016579:protein deubiquitination

1903843:cellular response to arsenite ion

0055085:transmembrane transport

0043531:ADP binding

0035617:stress granule disassembly

0005576:extracellular region

0036435:K48-linked polyubiquitin modification-dependent protein binding

0008289:lipid binding

0000502:proteasome complex

0098978:glutamatergic synapse

0043161:proteasome-mediated ubiquitin-dependent protein catabolic process

0035861:site of double-strand break

0006281:DNA repair

0010494:cytoplasmic stress granule

0036513:Derlin-1 retrotranslocation complex

0019079:viral genome replication

0016567:protein ubiquitination

1904949:ATPase complex

0051228:mitotic spindle disassembly

0031593:polyubiquitin modification-dependent protein binding

0005524:ATP binding

0005811:lipid droplet

0045732:positive regulation of protein catabolic process


2001171:positive regulation of ATP biosynthetic process

0010498:proteasomal protein catabolic process

0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process

0042802:identical protein binding

0036503:ERAD pathway

0097352:autophagosome maturation

0042288:MHC class I protein binding

0010918:positive regulation of mitochondrial membrane potential

1904288:BAT3 complex binding

0048471:perinuclear region of cytoplasm

0016887:ATPase activity

0005783:endoplasmic reticulum

1905634:regulation of protein localization to chromatin

0003723:RNA binding

0034098:VCP-NPL4-UFD1 AAA ATPase complex

0035578:azurophil granule lumen

1990381:ubiquitin-specific protease binding

0030433:ubiquitin-dependent ERAD pathway

0031334:positive regulation of protein-containing complex assembly

0035800:deubiquitinase activator activity

0090263:positive regulation of canonical Wnt signaling pathway

0019985:translesion synthesis

0006888:endoplasmic reticulum to Golgi vesicle-mediated transport

0031625:ubiquitin protein ligase binding

0030968:endoplasmic reticulum unfolded protein response

0045879:negative regulation of smoothened signaling pathway

0050807:regulation of synapse organization

0042981:regulation of apoptotic process

0034605:cellular response to heat

0071712:ER-associated misfolded protein catabolic process


0036297:interstrand cross-link repair

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0106300:protein-DNA covalent cross-linking repair

0006302:double-strand break repair


1903715:regulation of aerobic respiration

1903007:positive regulation of Lys63-specific deubiquitinase activity

0070842:aggresome assembly

1903862:positive regulation of oxidative phosphorylation

1903006:positive regulation of protein K63-linked deubiquitination

0070062:extracellular exosome

0061857:endoplasmic reticulum stress-induced pre-emptive quality control

0019904:protein domain specific binding

0005789:endoplasmic reticulum membrane

0072389:flavin adenine dinucleotide catabolic process

0070987:error-free translesion synthesis

0046034:ATP metabolic process


0044389:ubiquitin-like protein ligase binding


1904813:ficolin-1-rich granule lumen


0006734:NADH metabolic process

0043312:neutrophil degranulation

0034774:secretory granule lumen

0043231:intracellular membrane-bounded organelle

PDB 5KIY ; 6G2X ; 6HD0 ; 5FTM ; 6G2W ; 5GLF ; 4KDI ; 5EPP ; 5B6C ; 5KIW ; 5C19 ; 4KO8 ; 6G2Y ; 3HU3 ; 5FTK ; 3TIW ; 4KOD ; 5FTL ; 3QQ8 ; 5FTJ ; 3QC8 ; 5DYI ; 5C18 ; 4P0A ; 5IFS ; 3QWZ ; 5FTN ; 3HU1 ; 5X4L ; 6G2V ; 3EBB ; 5C1A ; 6G2Z ; 3HU2 ; 5DYG ; 5IFW ; 4KDL ; 4KLN ; 6G30 ; 3QQ7 ; 6MCK ; 5C1B
Drugbank DB04395 ; DB12695
KEGG hsa:7415

Related Compounds  (Total: 1)

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Name: Xanthohumol

Related Herbs  (Total: 11)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H0120 Ban Bian Qi半边旗 pinnated brake herbPteris semipinnata
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens