HIT-result

Type	Detail
Target ID	T21P7B
Protein Name	HLA class II histocompatibility antigen gamma chain
Uniprot ID	P04233
Protein Name Alias	HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; CD antigen CD74
Gene ID	972
Gene Symbol	CD74
Gene Alias	DHLAG
TTD	T08231: Clinical Trial target
Pfam	PF08831 ; PF00086 ; PF09307
GO	0002286:T cell activation involved in immune response 0090023:positive regulation of neutrophil chemotaxis 0001540:amyloid-beta binding 0050900:leukocyte migration 0035693:NOS2-CD74 complex 0045657:positive regulation of monocyte differentiation 0032755:positive regulation of interleukin-6 production 0016064:immunoglobulin mediated immune response 0035691:macrophage migration inhibitory factor signaling pathway 0070206:protein trimerization 0065003:protein-containing complex assembly 0045060:negative thymic T cell selection 0016021:integral component of membrane 0043518:negative regulation of DNA damage response, signal transduction by p53 class mediator 0002906:negative regulation of mature B cell apoptotic process 0046598:positive regulation of viral entry into host cell 0070374:positive regulation of ERK1 and ERK2 cascade 0005771:multivesicular body 0043202:lysosomal lumen 0035718:macrophage migration inhibitory factor binding 0060907:positive regulation of macrophage cytokine production 0006886:intracellular protein transport 0043066:negative regulation of apoptotic process 2000343:positive regulation of chemokine (C-X-C motif) ligand 2 production 0042802:identical protein binding 0031394:positive regulation of prostaglandin biosynthetic process 0050998:nitric-oxide synthase binding 0051085:chaperone cofactor-dependent protein refolding 0023026:MHC class II protein complex binding 0000139:Golgi membrane 0005737:cytoplasm 0030669:clathrin-coated endocytic vesicle membrane 0010628:positive regulation of gene expression 0001934:positive regulation of protein phosphorylation 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0071556:integral component of lumenal side of endoplasmic reticulum membrane 0050821:protein stabilization 0034341:response to interferon-gamma 0032757:positive regulation of interleukin-8 production 0019883:antigen processing and presentation of endogenous antigen 0008283:cell population proliferation 0019882:antigen processing and presentation 0019886:antigen processing and presentation of exogenous peptide antigen via MHC class II 0030658:transport vesicle membrane 0005634:nucleus 0043410:positive regulation of MAPK cascade 0005770:late endosome 0030336:negative regulation of cell migration 0045581:negative regulation of T cell differentiation 0044183:protein folding chaperone 0048146:positive regulation of fibroblast proliferation 0042609:CD4 receptor binding 1902166:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 0032722:positive regulation of chemokine production 0012507:ER to Golgi transport vesicle membrane 0002830:positive regulation of type 2 immune response 0005764:lysosome 0016020:membrane 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0009986:cell surface 0001961:positive regulation of cytokine-mediated signaling pathway 0045893:positive regulation of transcription, DNA-templated 0019955:cytokine binding 0001516:prostaglandin biosynthetic process 0042289:MHC class II protein binding 0030890:positive regulation of B cell proliferation 0002606:positive regulation of dendritic cell antigen processing and presentation 0035692:macrophage migration inhibitory factor receptor complex 0042658:MHC class II protein binding, via antigen binding groove 0070062:extracellular exosome 0030666:endocytic vesicle membrane 0045059:positive thymic T cell selection 0046597:negative regulation of viral entry into host cell 0000187:activation of MAPK activity 0005765:lysosomal membrane 0045582:positive regulation of T cell differentiation 0005886:plasma membrane 0002792:negative regulation of peptide secretion 0042613:MHC class II protein complex 0032991:protein-containing complex 0005773:vacuole 2000448:positive regulation of macrophage migration inhibitory factor signaling pathway 0033674:positive regulation of kinase activity 0045058:T cell selection 0004896:cytokine receptor activity 0009897:external side of plasma membrane 0043030:regulation of macrophage activation 0032588:trans-Golgi network membrane
PDB	1IIE ; 3QXD ; 4X5W ; 5KSU ; 1ICF ; 1L3H ; 3PDO ; 3QXA ; 3PGC ; 4AEN ; 1A6A ; 4AH2 ; 5KSV ; 1MUJ ; 3PGD
Drugbank	NA
KEGG	hsa:972

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Name: Methylglyoxal

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale