HIT-result

Type	Detail
Target ID	T23UM3
Protein Name	Sphingosine kinase 2
Uniprot ID	Q9NRA0
Protein Name Alias	SK 2; SPK 2; EC 2.7.1.91
Gene ID	56848
Gene Symbol	SPHK2
Gene Alias	SK2
TTD	T31989: Clinical Trial target
Pfam	PF00781
GO	0003951:NAD+ kinase activity 0005634:nucleus 0043306:positive regulation of mast cell degranulation 1903426:regulation of reactive oxygen species biosynthetic process 1904959:regulation of cytochrome-c oxidase activity 0005829:cytosol 0043980:histone H2B-K12 acetylation 0046512:sphingosine biosynthetic process 0017050:D-erythro-sphingosine kinase activity 2001169:regulation of ATP biosynthetic process 0006665:sphingolipid metabolic process 0032755:positive regulation of interleukin-6 production 0000786:nucleosome 0005765:lysosomal membrane 0001727:lipid kinase activity 0090280:positive regulation of calcium ion import 0006670:sphingosine metabolic process 0043122:regulation of I-kappaB kinase/NF-kappaB signaling 0005524:ATP binding 0005783:endoplasmic reticulum 0031064:negative regulation of histone deacetylation 0006669:sphinganine-1-phosphate biosynthetic process 0043231:intracellular membrane-bounded organelle 0008481:sphinganine kinase activity 0002720:positive regulation of cytokine production involved in immune response 0030308:negative regulation of cell growth 2000304:positive regulation of ceramide biosynthetic process 0016020:membrane 0031267:small GTPase binding 0030148:sphingolipid biosynthetic process 0045815:positive regulation of gene expression, epigenetic 0043065:positive regulation of apoptotic process 0032736:positive regulation of interleukin-13 production 0032760:positive regulation of tumor necrosis factor production 0005739:mitochondrion 0005737:cytoplasm 0090037:positive regulation of protein kinase C signaling 1901726:negative regulation of histone deacetylase activity 0038036:sphingosine-1-phosphate receptor activity 0016310:phosphorylation 0005743:mitochondrial inner membrane 0005654:nucleoplasm 1904628:cellular response to phorbol 13-acetate 12-myristate 0031493:nucleosomal histone binding 0043977:histone H2A-K5 acetylation 0033008:positive regulation of mast cell activation involved in immune response 2000617:positive regulation of histone H3-K9 acetylation
PDB	NA
Drugbank	DB12764
KEGG	hsa:56848

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Name: Dimethyl Sulfide

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0938	Da Suan	大蒜	Garlic	Allium sativum