Target Description
| Type | Detail |
|---|---|
| Target ID | T41Z8G |
| Protein Name | [Pyruvate dehydrogenase |
| Uniprot ID |
Q15118 |
| Protein Name Alias | acetyl-transferring; EC 2.7.11.2; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1 |
| Gene ID |
5163 |
| Gene Symbol | PDK1 |
| Gene Alias | PDHK1 |
| TTD | T15776: Clinical Trial target |
| Pfam | PF02518 ; PF10436 |
| GO |
0005759:mitochondrial matrix
0010510:regulation of acetyl-CoA biosynthetic process from pyruvate 0005739:mitochondrion 0010906:regulation of glucose metabolic process 0004740:pyruvate dehydrogenase (acetyl-transferring) kinase activity 0005967:mitochondrial pyruvate dehydrogenase complex 0004672:protein kinase activity 0097411:hypoxia-inducible factor-1alpha signaling pathway 0008631:intrinsic apoptotic signaling pathway in response to oxidative stress 0008283:cell population proliferation 0006468:protein phosphorylation 0005524:ATP binding 0006006:glucose metabolic process |
| PDB | 2Q8F ; 2Q8G ; 2Q8H |
| Drugbank | DB08809 ; DB07403 |
| KEGG | hsa:5163 |
Related Herbs (Total: 12)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0614 | Wu Zhao Long | 五爪龙 | Cairo morningglory | Ipomoea cairica |
| H0711 | Yuan Hua Zhi Tiao | 芫花枝条 | stem of lilac daphne | Daphne genkwa |
| H0289 | Niu Bang Zi | 牛蒡子 | Great burdock fruit | Arctium lappa |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H0709 | Chang Shan | 常山 | Antifebrile dichroa | Dichroa febrifuga |
| H0185 | Luo Shi Teng | 络石藤 | Chinese star jasmine | Trachelospermum jasminoides |
| H0707 | Yuan Hua | 芫花 | Lilac daphne | Daphne genkwa |
| H0918 | Cu Yuan Hua | 醋芫花 | Lilac daphne | Daphne genkwa |
| H0708 | Yuan Hua Gen | 芫花根 | Lilac daphne root | Daphne genkwa |
| H0710 | Yuan Hua Tiao | 芫花条 | stem of lilac daphne | Daphne genkwa |
| H0731 | Ye Mei Gui Guo | 野玫瑰果 | Rosehips | Rosa canina |
| H0146 | Liao Ge Wang | 了哥王 | NA | Wikstroemia indica |