HIT-result

Type	Detail
Target ID	T49XEM
Protein Name	Glycine receptor subunit alpha-1
Uniprot ID	P23415
Protein Name Alias	Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit
Gene ID	2741
Gene Symbol	GLRA1
Gene Alias	NA
TTD	T50269: Successful target
Pfam	PF02931 ; PF02932
GO	0006936:muscle contraction 1904315:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 0034220:ion transmembrane transport 0016021:integral component of membrane 0043200:response to amino acid 0030425:dendrite 0007268:chemical synaptic transmission 0006821:chloride transport 0043025:neuronal cell body 2000344:positive regulation of acrosome reaction 0001964:startle response 0060013:righting reflex 0030977:taurine binding 0007340:acrosome reaction 0042802:identical protein binding 0060080:inhibitory postsynaptic potential 0009897:external side of plasma membrane 0044877:protein-containing complex binding 0051970:negative regulation of transmission of nerve impulse 0006811:ion transport 0097305:response to alcohol 0060012:synaptic transmission, glycinergic 0007601:visual perception 0060077:inhibitory synapse 0045202:synapse 0034707:chloride channel complex 0005886:plasma membrane 0007628:adult walking behavior 0042391:regulation of membrane potential 0030594:neurotransmitter receptor activity 0043204:perikaryon 0001508:action potential 0043005:neuron projection 0005887:integral component of plasma membrane 0050877:nervous system process 0008270:zinc ion binding 1902476:chloride transmembrane transport 0005783:endoplasmic reticulum 0098690:glycinergic synapse 0044305:calyx of Held 0099060:integral component of postsynaptic specialization membrane 0007218:neuropeptide signaling pathway 0045211:postsynaptic membrane 0016934:extracellularly glycine-gated chloride channel activity 0004888:transmembrane signaling receptor activity 0071230:cellular response to amino acid stimulus 0050884:neuromuscular process controlling posture 0099056:integral component of presynaptic membrane 0071361:cellular response to ethanol 0071294:cellular response to zinc ion 0002087:regulation of respiratory gaseous exchange by nervous system process 0043231:intracellular membrane-bounded organelle 0007165:signal transduction 0016594:glycine binding
PDB	4X5T ; 2M6I ; 1VRY ; 1MOT ; 2M6B
Drugbank	DB00466 ; DB01028 ; DB09061 ; DB05417 ; DB14533 ; DB03929 ; DB00431 ; DB00572 ; DB00898 ; DB11582 ; DB05885 ; DB09130 ; DB14011 ; DB01236 ; DB01043 ; DB00753 ; DB01381 ; DB01593 ; DB01189 ; DB14009 ; DB01159 ; DB14548 ; DB01956 ; DB00228 ; DB14487 ; DB00145
KEGG	hsa:2741

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Name: strychnine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name