HIT-result

Type	Detail
Target ID	T59P8I
Protein Name	Potassium voltage-gated channel subfamily H member 2
Uniprot ID	Q12809
Protein Name Alias	Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1
Gene ID	3757
Gene Symbol	KCNH2
Gene Alias	ERG; ERG1; HERG
TTD	T20251: Successful target
Pfam	PF00027 ; PF00520 ; PF13426
GO	0035690:cellular response to drug 0000976:transcription regulatory region sequence-specific DNA binding 0031625:ubiquitin protein ligase binding 0071805:potassium ion transmembrane transport 1901381:positive regulation of potassium ion transmembrane transport 0055131:C3HC4-type RING finger domain binding 0086010:membrane depolarization during action potential 0060048:cardiac muscle contraction 0005251:delayed rectifier potassium channel activity 0003064:regulation of heart rate by hormone 0055075:potassium ion homeostasis 0009986:cell surface 0086091:regulation of heart rate by cardiac conduction 0060306:regulation of membrane repolarization 0042802:identical protein binding 0097110:scaffold protein binding 0005886:plasma membrane 0042391:regulation of membrane potential 1902937:inward rectifier potassium channel complex 0005887:integral component of plasma membrane 0005242:inward rectifier potassium channel activity 0098915:membrane repolarization during ventricular cardiac muscle cell action potential 0045893:positive regulation of transcription, DNA-templated 0048471:perinuclear region of cytoplasm 1902282:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1901380:negative regulation of potassium ion transmembrane transport 1990573:potassium ion import across plasma membrane 0061337:cardiac conduction 0086008:voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 0008076:voltage-gated potassium channel complex 0086009:membrane repolarization 0086005:ventricular cardiac muscle cell action potential 0042803:protein homodimerization activity 1903765:negative regulation of potassium ion export across plasma membrane 0086011:membrane repolarization during action potential 0097623:potassium ion export across plasma membrane 0005249:voltage-gated potassium channel activity 1901379:regulation of potassium ion transmembrane transport 0086013:membrane repolarization during cardiac muscle cell action potential 0060307:regulation of ventricular cardiac muscle cell membrane repolarization
PDB	4HP9 ; 2L4R ; 1BYW ; 2L0W ; 2N7G ; 5VA2 ; 2LE7 ; 4HQA ; 2L1M ; 5VA1 ; 6SYG ; 5VA3 ; 1UJL
Drugbank	DB00276 ; DB00675 ; DB00679 ; DB00537 ; DB01110 ; DB00204 ; DB00176 ; DB01026 ; DB00590 ; DB01035 ; DB11633 ; DB01118 ; DB00280 ; DB01218 ; DB11642 ; DB01244 ; DB01182 ; DB00458 ; DB11186 ; DB00908 ; DB06217 ; DB00457 ; DB01069 ; DB00477 ; DB01100 ; DB00346 ; DB12364 ; DB00199 ; DB01162 ; DB01074 ; DB01142 ; DB11090 ; DB01195 ; DB00455 ; DB06457 ; DB00321 ; DB00661 ; DB01211 ; DB00557 ; DB00252 ; DB00472 ; DB04957 ; DB00308 ; DB01136 ; DB01149 ; DB06144 ; DB00489 ; DB00604 ; DB00637 ; DB04855 ; DB00228 ; DB11386 ; DB00342
KEGG	hsa:3757

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 0)