HIT-result

Type	Detail
Target ID	T62OED
Protein Name	Secreted frizzled-related protein 2
Uniprot ID	Q96HF1
Protein Name Alias	FRP-2; sFRP-2; Secreted apoptosis-related protein 1; SARP-1
Gene ID	6423
Gene Symbol	SFRP2
Gene Alias	FRP2; SARP1
TTD	NA
Pfam	PF01392 ; PF01759
GO	0050732:negative regulation of peptidyl-tyrosine phosphorylation 0010719:negative regulation of epithelial to mesenchymal transition 0048018:receptor ligand activity 0001968:fibronectin binding 0017147:Wnt-protein binding 0010975:regulation of neuron projection development 0030336:negative regulation of cell migration 0003214:cardiac left ventricle morphogenesis 0060349:bone morphogenesis 0071425:hematopoietic stem cell proliferation 0071481:cellular response to X-ray 1904956:regulation of midbrain dopaminergic neuron differentiation 0090244:Wnt signaling pathway involved in somitogenesis 0008284:positive regulation of cell population proliferation 0006915:apoptotic process 0042733:embryonic digit morphogenesis 0008285:negative regulation of cell population proliferation 0045892:negative regulation of transcription, DNA-templated 0033630:positive regulation of cell adhesion mediated by integrin 2000035:regulation of stem cell division 0045600:positive regulation of fat cell differentiation 0005615:extracellular space 0031668:cellular response to extracellular stimulus 0061133:endopeptidase activator activity 0042662:negative regulation of mesodermal cell fate specification 0060070:canonical Wnt signaling pathway 0050680:negative regulation of epithelial cell proliferation 1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 0030199:collagen fibril organization 0030308:negative regulation of cell growth 0010629:negative regulation of gene expression 0030178:negative regulation of Wnt signaling pathway 0042493:response to drug 0007267:cell-cell signaling 0001569:branching involved in blood vessel morphogenesis 0048546:digestive tract morphogenesis 0030514:negative regulation of BMP signaling pathway 0007584:response to nutrient 0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0005178:integrin binding 0061056:sclerotome development 0008584:male gonad development 1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 0062023:collagen-containing extracellular matrix 0045669:positive regulation of osteoblast differentiation 0043065:positive regulation of apoptotic process 0061185:negative regulation of dermatome development 0002063:chondrocyte development 0045766:positive regulation of angiogenesis 0030307:positive regulation of cell growth 0090090:negative regulation of canonical Wnt signaling pathway 0090179:planar cell polarity pathway involved in neural tube closure 0036342:post-anal tail morphogenesis 0033138:positive regulation of peptidyl-serine phosphorylation 0003151:outflow tract morphogenesis 0045944:positive regulation of transcription by RNA polymerase II 0043508:negative regulation of JUN kinase activity 0090263:positive regulation of canonical Wnt signaling pathway 2000041:negative regulation of planar cell polarity pathway involved in axis elongation 0010667:negative regulation of cardiac muscle cell apoptotic process 0060028:convergent extension involved in axis elongation
PDB	NA
Drugbank	NA
KEGG	hsa:6423

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Name: Amarogentin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1245	Bai Qian	白前	Cynanchum root	Cynanchum stauntonii
H0961	Dang Yao	当药	Chinese swertia	Swertia chinensis
H0162	Long Dan	龙胆	Rough gentian	Gentiana scabra