HIT-result

Target Description

Type	Detail
Target ID	T74UH3
Protein Name	Mitofusin-2
Uniprot ID	O95140
Protein Name Alias	EC 3.6.5.-; Transmembrane GTPase MFN2
Gene ID	9927
Gene Symbol	MFN2
Gene Alias	CPRP1; KIAA0214
TTD	NA
Pfam	PF00350 ; PF04799
GO	0008053:mitochondrial fusion 1904707:positive regulation of vascular associated smooth muscle cell proliferation 0120162:positive regulation of cold-induced thermogenesis 0061734:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 0016236:macroautophagy 0006986:response to unfolded protein 0051646:mitochondrion localization 0031625:ubiquitin protein ligase binding 1905461:positive regulation of vascular associated smooth muscle cell apoptotic process 0006915:apoptotic process 0048662:negative regulation of smooth muscle cell proliferation 0005829:cytosol 0007596:blood coagulation 0005741:mitochondrial outer membrane 0016021:integral component of membrane 0003924:GTPase activity 0006626:protein targeting to mitochondrion 0005739:mitochondrion 0046580:negative regulation of Ras protein signal transduction 0031306:intrinsic component of mitochondrial outer membrane 0005525:GTP binding 0034497:protein localization to phagophore assembly site 0007006:mitochondrial membrane organization
PDB	6JFL ; 6JFK ; 6JFM
Drugbank	NA
KEGG	hsa:9927

Type

Detail

Target ID

T74UH3

Protein Name

Mitofusin-2

Uniprot ID

O95140

Protein Name Alias

EC 3.6.5.-; Transmembrane GTPase MFN2

Gene ID

9927

Gene Symbol

MFN2

Gene Alias

CPRP1; KIAA0214

TTD

Pfam

PF00350 ; PF04799

0008053:mitochondrial fusion

1904707:positive regulation of vascular associated smooth muscle cell proliferation

0120162:positive regulation of cold-induced thermogenesis

0061734:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

0016236:macroautophagy

0006986:response to unfolded protein

0051646:mitochondrion localization

0031625:ubiquitin protein ligase binding

1905461:positive regulation of vascular associated smooth muscle cell apoptotic process

0006915:apoptotic process

0048662:negative regulation of smooth muscle cell proliferation

0005829:cytosol

0007596:blood coagulation

0005741:mitochondrial outer membrane

0016021:integral component of membrane

0003924:GTPase activity

0006626:protein targeting to mitochondrion

0005739:mitochondrion

0046580:negative regulation of Ras protein signal transduction

0031306:intrinsic component of mitochondrial outer membrane

0005525:GTP binding

0034497:protein localization to phagophore assembly site

0007006:mitochondrial membrane organization

PDB

6JFL ; 6JFK ; 6JFM

Drugbank

KEGG

hsa:9927

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0826	Chu Mu Dan	臭牡丹	rose glorybower	Clerodendrum bungei
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0246	Mi Ma Huang	蜜麻黄	Ephedra equisetin	Ephedra sinica
H0120	Ban Bian Qi	半边旗	pinnated brake herb	Pteris semipinnata
H0200	Ma Huang Gen	麻黄根	Chinese ephedra root	Ephedra sinica
H0198	Ma Huang Gao	麻黄膏	Chinese ephedra	Ephedra sinica
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0957	Dang Gui Teng	当归藤	NA	Embelia parviflora
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0201	Ma Huang Jin Gao	麻黄浸膏	Chinese ephedra	Ephedra sinica
H0197	Ma Huang	麻黄	Chinese ephedra	Ephedra sinica

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 11)