HIT-result

Target Description

Type	Detail
Target ID	T74XTP
Protein Name	Lanosterol 14-alpha demethylase
Uniprot ID	Q16850
Protein Name Alias	LDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase
Gene ID	1595
Gene Symbol	CYP51A1
Gene Alias	CYP51
TTD	T32972: Clinical Trial target
Pfam	PF00067
GO	0019216:regulation of lipid metabolic process 0004497:monooxygenase activity 0016021:integral component of membrane 0006695:cholesterol biosynthetic process 0007399:nervous system development 0020037:heme binding 0006694:steroid biosynthetic process 0005783:endoplasmic reticulum 0042177:negative regulation of protein catabolic process 0016020:membrane 0005789:endoplasmic reticulum membrane 0016491:oxidoreductase activity 1900222:negative regulation of amyloid-beta clearance 0050709:negative regulation of protein secretion 0016125:sterol metabolic process 0005506:iron ion binding 0008398:sterol 14-demethylase activity
PDB	6UEZ ; 4UHI ; 6Q2T ; 4UHL ; 3JUV ; 3JUS ; 3LD6
Drugbank	DB01167 ; DB05667 ; DB01110 ; DB07705 ; DB01007
KEGG	hsa:1595

Type

Detail

Target ID

T74XTP

Protein Name

Lanosterol 14-alpha demethylase

Uniprot ID

Q16850

Protein Name Alias

LDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase

Gene ID

1595

Gene Symbol

CYP51A1

Gene Alias

CYP51

TTD

T32972: Clinical Trial target

Pfam

PF00067

0019216:regulation of lipid metabolic process

0004497:monooxygenase activity

0016021:integral component of membrane

0006695:cholesterol biosynthetic process

0007399:nervous system development

0020037:heme binding

0006694:steroid biosynthetic process

0005783:endoplasmic reticulum

0042177:negative regulation of protein catabolic process

0016020:membrane

0005789:endoplasmic reticulum membrane

0016491:oxidoreductase activity

1900222:negative regulation of amyloid-beta clearance

0050709:negative regulation of protein secretion

0016125:sterol metabolic process

0005506:iron ion binding

0008398:sterol 14-demethylase activity

PDB

6UEZ ; 4UHI ; 6Q2T ; 4UHL ; 3JUV ; 3JUS ; 3LD6

Drugbank

DB01167 ; DB05667 ; DB01110 ; DB07705 ; DB01007

KEGG

hsa:1595

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0292	Niu Jiao Jian Fen	牛角尖粉	Buffalo horn	Bubalus bubalis
H0293	Niu Jiao Tan	牛角炭	Buffalo horn	Bubalus bubalis
H0488	Shui Niu Jiao Gan Jin Gao	水牛角干浸膏	Buffalo horn	Bubalus bubalis
H0489	Shui Niu Jiao Nong Suo Fen	水牛角浓缩粉	Buffalo horn	Bubalus bubalis
H0487	Shui Niu Jiao	水牛角	Buffalo horn	Bubalus bubalis
H0291	Niu Jiao Fen	牛角粉	Buffalo horn	Bubalus bubalis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 8)