Target Description

Type Detail
Target ID T77W8L
Protein Name Ribosomal protein S6 kinase alpha-1
Uniprot ID Q15418
Protein Name Alias S6K-alpha-1;  EC 2.7.11.1;  90 kDa ribosomal protein S6 kinase 1;  p90-RSK 1;  p90RSK1;  p90S6K;  MAP kinase-activated protein kinase 1a;  MAPK-activated protein kinase 1a;  MAPKAP kinase 1a;  MAPKAPK-1a;  Ribosomal S6 kinase 1;  RSK-1
Gene ID 6195
Gene Symbol RPS6KA1
Gene Alias MAPKAPK1A;  RSK1
TTD T83202: Patented target
Pfam PF00069 ; PF00433
GO
0004674:protein serine/threonine kinase activity

0035556:intracellular signal transduction

0045597:positive regulation of cell differentiation

0005524:ATP binding

0043066:negative regulation of apoptotic process

0007268:chemical synaptic transmission

0106311:protein threonine kinase activity

0018105:peptidyl-serine phosphorylation

0005829:cytosol

0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0043555:regulation of translation in response to stress

0030307:positive regulation of cell growth

0000287:magnesium ion binding

0005737:cytoplasm

0005654:nucleoplasm

0004711:ribosomal protein S6 kinase activity

0045893:positive regulation of transcription, DNA-templated

0043027:cysteine-type endopeptidase inhibitor activity involved in apoptotic process

0072574:hepatocyte proliferation

0007049:cell cycle

0045944:positive regulation of transcription by RNA polymerase II

0043620:regulation of DNA-templated transcription in response to stress

0004712:protein serine/threonine/tyrosine kinase activity

0106310:protein serine kinase activity

0007165:signal transduction

2000491:positive regulation of hepatic stellate cell activation

PDB 5CSN ; 4NIF ; 2Z7R ; 5N7D ; 5CSJ ; 5N7F ; 2WNT ; 2Z7Q ; 2Z7S ; 3TEI ; 5CSI ; 5N7G ; 5V62 ; 3RNY ; 4H3P ; 5V61 ; 5CSF ; 6TWY
Drugbank DB04751 ; DB12010
KEGG hsa:6195

Related Compounds  (Total: 1)

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C0355
Name: Quetiapine


Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens