HIT-result

Type	Detail
Target ID	T88M4K
Protein Name	Furin
Uniprot ID	P09958
Protein Name Alias	EC 3.4.21.75; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE
Gene ID	5045
Gene Symbol	FURIN
Gene Alias	FUR; PACE; PCSK3
TTD	T68706: Preclinical target
Pfam	PF16470 ; PF01483 ; PF00082
GO	0022617:extracellular matrix disassembly 0001825:blastocyst formation 0016486:peptide hormone processing 0070062:extracellular exosome 0007179:transforming growth factor beta receptor signaling pathway 0097341:zymogen inhibition 0048406:nerve growth factor binding 0019058:viral life cycle 0032804:negative regulation of low-density lipoprotein particle receptor catabolic process 0090472:dibasic protein processing 0030173:integral component of Golgi membrane 0043043:peptide biosynthetic process 0000139:Golgi membrane 0070268:cornification 0006465:signal peptide processing 0030198:extracellular matrix organization 0032374:regulation of cholesterol transport 0042176:regulation of protein catabolic process 0042277:peptide binding 0004867:serine-type endopeptidase inhibitor activity 0005783:endoplasmic reticulum 0030574:collagen catabolic process 0005886:plasma membrane 0002862:negative regulation of inflammatory response to antigenic stimulus 0052548:regulation of endopeptidase activity 0045121:membrane raft 0030140:trans-Golgi network transport vesicle 0002020:protease binding 0016020:membrane 1990000:amyloid fibril formation 0032902:nerve growth factor production 0009986:cell surface 0009966:regulation of signal transduction 0005796:Golgi lumen 1901394:positive regulation of transforming growth factor beta1 activation 0032455:nerve growth factor processing 0051004:regulation of lipoprotein lipase activity 0005576:extracellular region 0008233:peptidase activity 0016485:protein processing 0046872:metal ion binding 0019082:viral protein processing 0004252:serine-type endopeptidase activity 0005802:trans-Golgi network 0051044:positive regulation of membrane protein ectodomain proteolysis 0032940:secretion by cell 0032911:negative regulation of transforming growth factor beta1 production 0004175:endopeptidase activity 0010008:endosome membrane 0031638:zymogen activation
PDB	5MIM ; 5JXG ; 5JMO ; 6HZA ; 4OMC ; 5JXI ; 5JXJ ; 5JXH ; 6HZC ; 6HZD ; 6EQW ; 6HLB ; 4OMD ; 6EQX ; 4RYD ; 6A8Y ; 6EQV ; 6HLE ; 6HZB ; 4Z2A ; 6HLD
Drugbank	DB03600
KEGG	hsa:5045

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Name: Benzene

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens