HIT-result

Type	Detail
Target ID	T96NMT
Protein Name	Serine/threonine-protein kinase PINK1, mitochondrial
Uniprot ID	Q9BXM7
Protein Name Alias	EC 2.7.11.1; BRPK; PTEN-induced putative kinase protein 1
Gene ID	65018
Gene Symbol	PINK1
Gene Alias	NA
TTD	NA
Pfam	PF00069
GO	0035556:intracellular signal transduction 0004672:protein kinase activity 0043422:protein kinase B binding 0046329:negative regulation of JNK cascade 0106310:protein serine kinase activity 0002931:response to ischemia 0004674:protein serine/threonine kinase activity 0016236:macroautophagy 0034599:cellular response to oxidative stress 1902803:regulation of synaptic vesicle transport 0097413:Lewy body 0018105:peptidyl-serine phosphorylation 0090200:positive regulation of release of cytochrome c from mitochondria 0005783:endoplasmic reticulum 0031398:positive regulation of protein ubiquitination 0010629:negative regulation of gene expression 1903298:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway 1903955:positive regulation of protein targeting to mitochondrion 1903751:negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 0006979:response to oxidative stress 0098779:positive regulation of mitophagy in response to mitochondrial depolarization 0030424:axon 0007005:mitochondrion organization 0033603:positive regulation of dopamine secretion 0043254:regulation of protein-containing complex assembly 0038203:TORC2 signaling 0042981:regulation of apoptotic process 0005829:cytosol 0071456:cellular response to hypoxia 0051443:positive regulation of ubiquitin-protein transferase activity 0031307:integral component of mitochondrial outer membrane 0051897:positive regulation of protein kinase B signaling 0032148:activation of protein kinase B activity 0090141:positive regulation of mitochondrial fission 0005737:cytoplasm 1902958:positive regulation of mitochondrial electron transport, NADH to ubiquinone 0006511:ubiquitin-dependent protein catabolic process 0045727:positive regulation of translation 1902902:negative regulation of autophagosome assembly 0005524:ATP binding 0001934:positive regulation of protein phosphorylation 0048471:perinuclear region of cytoplasm 1900407:regulation of cellular response to oxidative stress 0002020:protease binding 0000422:autophagy of mitochondrion 0010310:regulation of hydrogen peroxide metabolic process 0050821:protein stabilization 0006468:protein phosphorylation 0051091:positive regulation of DNA-binding transcription factor activity 0005739:mitochondrion 0005743:mitochondrial inner membrane 0061136:regulation of proteasomal protein catabolic process 0033138:positive regulation of peptidyl-serine phosphorylation 0016504:peptidase activator activity 0051881:regulation of mitochondrial membrane potential 0030426:growth cone 0005634:nucleus 0043524:negative regulation of neuron apoptotic process 0055131:C3HC4-type RING finger domain binding 0072656:maintenance of protein location in mitochondrion 2001243:negative regulation of intrinsic apoptotic signaling pathway 0097237:cellular response to toxic substance 0036289:peptidyl-serine autophosphorylation 0106311:protein threonine kinase activity 0016242:negative regulation of macroautophagy 0031625:ubiquitin protein ligase binding 1901727:positive regulation of histone deacetylase activity 0016301:kinase activity 1904841:TORC2 complex binding 1903146:regulation of autophagy of mitochondrion 0044877:protein-containing complex binding 1904881:cellular response to hydrogen sulfide 1903147:negative regulation of autophagy of mitochondrion 0097449:astrocyte projection 0005741:mitochondrial outer membrane 0002082:regulation of oxidative phosphorylation 0005856:cytoskeleton 0016020:membrane 1903204:negative regulation of oxidative stress-induced neuron death 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0099074:mitochondrion to lysosome transport 1903214:regulation of protein targeting to mitochondrion 0010857:calcium-dependent protein kinase activity 0010952:positive regulation of peptidase activity 0016567:protein ubiquitination 0035307:positive regulation of protein dephosphorylation 2000378:negative regulation of reactive oxygen species metabolic process 0032226:positive regulation of synaptic transmission, dopaminergic 1904544:positive regulation of free ubiquitin chain polymerization 1903384:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 2000377:regulation of reactive oxygen species metabolic process 0031396:regulation of protein ubiquitination 1903852:positive regulation of cristae formation 0044297:cell body 0000287:magnesium ion binding 0000785:chromatin 0072655:establishment of protein localization to mitochondrion 2001171:positive regulation of ATP biosynthetic process 0022904:respiratory electron transport chain 0005758:mitochondrial intermembrane space 1903202:negative regulation of oxidative stress-induced cell death 0010821:regulation of mitochondrion organization 0016239:positive regulation of macroautophagy 1904783:positive regulation of NMDA glutamate receptor activity 0090258:negative regulation of mitochondrial fission
PDB	NA
Drugbank	NA
KEGG	hsa:65018

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Name: Kinetin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0137	Ban Lan Gen	板蓝根	Indigowoad root	Isatis indigotica
H0131	Ban Lan	板蓝	Indigowoad root	Isatis indigotica
H0263	Mu Ban Lan Gen	木板蓝根	Indigowoad root	Isatis indigotica
H0265	Mu Da Qing Ye	木大青叶	Indigo-coloured woad leaf equivalent	Isatis indigotica
H0937	Da Qing Ye	大青叶	Indigo-coloured woad leaf	Isatis indigotica