Target Description

Type Detail
Target ID T96PBE
Protein Name Tyrosine-protein phosphatase non-receptor type 2
Uniprot ID P17706
Protein Name Alias EC 3.1.3.48;  T-cell protein-tyrosine phosphatase;  TCPTP
Gene ID 5771
Gene Symbol PTPN2
Gene Alias PTPT
TTD T49156: Clinical Trial target
Pfam PF00102
GO
0005634:nucleus

0042532:negative regulation of tyrosine phosphorylation of STAT protein

0071345:cellular response to cytokine stimulus

0035335:peptidyl-tyrosine dephosphorylation

0030218:erythrocyte differentiation

0004725:protein tyrosine phosphatase activity

0046627:negative regulation of insulin receptor signaling pathway

0008285:negative regulation of cell population proliferation

0060336:negative regulation of interferon-gamma-mediated signaling pathway

1902233:negative regulation of positive thymic T cell selection

0030217:T cell differentiation

0030971:receptor tyrosine kinase binding

0050922:negative regulation of chemotaxis

0004726:non-membrane spanning protein tyrosine phosphatase activity

0042059:negative regulation of epidermal growth factor receptor signaling pathway

0019905:syntaxin binding

0019901:protein kinase binding

0070104:negative regulation of interleukin-6-mediated signaling pathway

0045650:negative regulation of macrophage differentiation

0005829:cytosol

0061099:negative regulation of protein tyrosine kinase activity

0005783:endoplasmic reticulum

1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

0005886:plasma membrane

0060334:regulation of interferon-gamma-mediated signaling pathway

0030183:B cell differentiation

0010804:negative regulation of tumor necrosis factor-mediated signaling pathway

0060339:negative regulation of type I interferon-mediated signaling pathway

0050728:negative regulation of inflammatory response

0005178:integrin binding

0008286:insulin receptor signaling pathway

1902206:negative regulation of interleukin-2-mediated signaling pathway

0005793:endoplasmic reticulum-Golgi intermediate compartment

0050860:negative regulation of T cell receptor signaling pathway

1902202:regulation of hepatocyte growth factor receptor signaling pathway

2000587:negative regulation of platelet-derived growth factor receptor-beta signaling pathway

0000122:negative regulation of transcription by RNA polymerase II

1902227:negative regulation of macrophage colony-stimulating factor signaling pathway

1903899:positive regulation of PERK-mediated unfolded protein response

0042593:glucose homeostasis

0005654:nucleoplasm

0097677:STAT family protein binding

1902215:negative regulation of interleukin-4-mediated signaling pathway

0010888:negative regulation of lipid storage

0045722:positive regulation of gluconeogenesis

0070373:negative regulation of ERK1 and ERK2 cascade

PDB 1L8K
Drugbank NA
KEGG hsa:5771

Related Compounds  (Total: 2)

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C0029
Name: Diphenylether
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C0412
Name: Spermidine


Related Herbs  (Total: 14)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0416 Shan Shen山参 NAPanax ginseng
H0194 Ma Bing Lang马槟榔 Masaikai caperCapparis masaikai
H0357 Ren Shen人参 GinsengPanax ginseng
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0026 Jiang Soybean pasteGlycine max
H1007 Dou You豆油 Soybean oilGlycine max
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0944 Dan Dou Gu淡豆鼓 NAGlycine max