Compound Description
| ID: C0464 | Common name: Tryptanthrin |
| IUPAC: indolo[2,1-b]quinazoline-6,12-dione | CAS: CAS:13220-57-0 |
| Chembl ID: CHEMBL306946 | Pubchem ID: CID:73549 |
| Formula: C15H8N2O2 | TCM-ID: TCMC2196 |
| Smiles: C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2 | |
| Alias:
Couroupitine A;
NSC 349447; Triptantrin; Tryptanthrin; Tryptanthrine |
Structure:
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Related Targets (Total: 9)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T11HTL | Apelin | APLN |
Q9ULZ1 |
A | 1 Reference(s) |
| T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
A | 1 Reference(s) |
| T45X9Z | Hepatocyte growth factor | HGF |
P14210 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
B | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
C | 2 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
C | 2 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 13)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0763 | Yu Mi Xu | 玉米须 | Maize style | Zea mays |
| H0137 | Ban Lan Gen | 板蓝根 | Indigowoad root | Isatis indigotica |
| H0677 | Chan Chu | 蟾蜍 | Toad | Bufo melanostictus |
| H0277 | Nan Ban Lan Gen | 南板蓝根 | Indigowoad root | Baphicacanthus cusia |
| H0937 | Da Qing Ye | 大青叶 | Indigo-coloured woad leaf | Isatis indigotica |
| H0215 | Mai Ya | 麦芽 | Barley germinating fruit | Hordeum vulgare |
| H0278 | Nan Ban Lan Gen Jin Gao Fen | 南板蓝根浸膏粉 | Indigowoad root | Baphicacanthus cusia |
| H0263 | Mu Ban Lan Gen | 木板蓝根 | Indigowoad root | Isatis indigotica |
| H0265 | Mu Da Qing Ye | 木大青叶 | Indigo-coloured woad leaf equivalent | Isatis indigotica |
| H0131 | Ban Lan | 板蓝 | Indigowoad root | Isatis indigotica |
| H0339 | Qing Dai | 青黛 | Natural indigo | Indigo naturalis |
| H1078 | Gan Chan | 干蟾 | NA | Bufo melanostictus |
| H0145 | Liao Da Qing Ye | 蓼大青叶 | Indigoplant leaf | Folium polygoni tinctorii |
Ckey description of the interaction between compound and target