HIT-result

Type	Detail
Target ID	T45X9Z
Protein Name	Hepatocyte growth factor
Uniprot ID	P14210
Protein Name Alias	Hepatopoietin-A; Scatter factor; SF
Gene ID	3082
Gene Symbol	HGF
Gene Alias	HPTA
TTD	T83797: Clinical Trial target
Pfam	PF00089 ; PF00024 ; PF00051
GO	0001837:epithelial to mesenchymal transition 0050728:negative regulation of inflammatory response 0031093:platelet alpha granule lumen 0045766:positive regulation of angiogenesis 0060665:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling 0019221:cytokine-mediated signaling pathway 0004252:serine-type endopeptidase activity 0000187:activation of MAPK activity 0070572:positive regulation of neuron projection regeneration 0001934:positive regulation of protein phosphorylation 0016020:membrane 0010507:negative regulation of autophagy 1902947:regulation of tau-protein kinase activity 0008083:growth factor activity 0002576:platelet degranulation 0090201:negative regulation of release of cytochrome c from mitochondria 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0043066:negative regulation of apoptotic process 0000902:cell morphogenesis 0042802:identical protein binding 0005615:extracellular space 0030212:hyaluronan metabolic process 1900744:regulation of p38MAPK cascade 0048012:hepatocyte growth factor receptor signaling pathway 0045944:positive regulation of transcription by RNA polymerase II 0005576:extracellular region 0035729:cellular response to hepatocyte growth factor stimulus 0044877:protein-containing complex binding 0060326:cell chemotaxis 0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 1901299:negative regulation of hydrogen peroxide-mediated programmed cell death 0045669:positive regulation of osteoblast differentiation 0031100:animal organ regeneration 0000278:mitotic cell cycle 0000165:MAPK cascade 0031643:positive regulation of myelination 0042056:chemoattractant activity 0030335:positive regulation of cell migration 0032715:negative regulation of interleukin-6 production 2000573:positive regulation of DNA biosynthetic process 0032733:positive regulation of interleukin-10 production 0051450:myoblast proliferation 0051897:positive regulation of protein kinase B signaling 1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 0001889:liver development 0050673:epithelial cell proliferation 0033137:negative regulation of peptidyl-serine phosphorylation 0014068:positive regulation of phosphatidylinositol 3-kinase signaling
PDB	5CS9 ; 1NK1 ; 2QJ2 ; 3SP8 ; 3MKP ; 4K3J ; 5CP9 ; 1GMN ; 4O3U ; 3HMT ; 1GMO ; 1SI5 ; 5CT2 ; 1GP9 ; 5CSQ ; 4O3T ; 1BHT ; 2HGF ; 5CS1 ; 5CS3 ; 1SHY ; 5CT3 ; 4D3C ; 3HMS ; 5CS5 ; 3HN4 ; 5COE ; 5CT1
Drugbank	DB12307 ; DB01109 ; DB02264 ; DB03959 ; DB05434
KEGG	hsa:3082

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Name: Resveratrol

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Name: Tryptanthrin

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Name: Matrine

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Name: Madecassoside

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Name: heparin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H0265	Mu Da Qing Ye	木大青叶	Indigo-coloured woad leaf equivalent	Isatis indigotica
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0145	Liao Da Qing Ye	蓼大青叶	Indigoplant leaf	Folium polygoni tinctorii
H0137	Ban Lan Gen	板蓝根	Indigowoad root	Isatis indigotica
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0937	Da Qing Ye	大青叶	Indigo-coloured woad leaf	Isatis indigotica
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0131	Ban Lan	板蓝	Indigowoad root	Isatis indigotica
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0339	Qing Dai	青黛	Natural indigo	Indigo naturalis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0405	Shan Dou Gen	山豆根	Tonkin sophora root	Sophora subprostrata
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0263	Mu Ban Lan Gen	木板蓝根	Indigowoad root	Isatis indigotica
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0763	Yu Mi Xu	玉米须	Maize style	Zea mays
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0215	Mai Ya	麦芽	Barley germinating fruit	Hordeum vulgare
H0416	Shan Shen	山参	NA	Panax ginseng
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 41)