Herb Description
| Herb ID: H0926 | Chinese Character: 大黄 |
| English Name: Medicinal rhubarb | Latin Name: Rheum officinale |
| Chinese Pin Yin : Da Huang | TCM-ID: TCMH363 |
| Therapeutic Function in Chinese : 泻下 | Therapeutic Function in English: Purging |
| Herb Function: Cause catharsis and purge away heat, reduce heat in blood and counteract toxicity, and eliminate blood stasis and stimulate menstrual discharge | |
Related Targets (Total: 415)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T76PKX | Mast/stem cell growth factor receptor Kit | KIT |
P10721 |
1 Reference(s) |
| T40DIM | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 |
P28845 |
2 Reference(s) |
| T54VET | Protein tyrosine phosphatase type IVA 3 | PTP4A3 |
O75365 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
12 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
6 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
2 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
11 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
3 Reference(s) |
| T12RJE | Casein kinase II subunit alpha' | CSNK2A2 |
P19784 |
1 Reference(s) |
| T47C6A | Phosphoglycerate mutase 1 | PGAM1 |
P18669 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
14 Reference(s) |
| T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
3 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
16 Reference(s) |
| T24OK4 | Rho-associated protein kinase 2 | Rock2 |
Q62868 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
10 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
6 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
4 Reference(s) |
| T76C5R | Parathyroid hormone-related protein | PTHLH |
P12272 |
1 Reference(s) |
| T77WRE | Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase | CMAHP |
Q9Y471 |
1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
8 Reference(s) |
| T83COK | 5-hydroxytryptamine receptor 2C | HTR2C |
P28335 |
1 Reference(s) |
| T39T57 | Tryptophan 5-hydroxylase 1 | TPH1 |
P17752 |
1 Reference(s) |
| T61NZN | Progonadoliberin-1 | GNRH1 |
P01148 |
1 Reference(s) |
| T29B10 | Interleukin-17A | IL17A |
Q16552 |
2 Reference(s) |
| T13HNJ | NA | TERC |
NA |
1 Reference(s) |
| T84YTJ | Glutamate receptor 4 | GRIA4 |
P48058 |
1 Reference(s) |
| T03GNH | Alpha-2B adrenergic receptor | ADRA2B |
P18089 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
12 Reference(s) |
| T39GNZ | 5-hydroxytryptamine receptor 3A | HTR3A |
P46098 |
1 Reference(s) |
| T97ZTQ | 5-hydroxytryptamine receptor 1B | HTR1B |
P28222 |
1 Reference(s) |
| T86YQL | Prolactin | PRL |
P01236 |
1 Reference(s) |
| T48ZIG | D(2) dopamine receptor | DRD2 |
P14416 |
1 Reference(s) |
| T36O3K | Beta-adrenergic receptor kinase 1 | GRK2 |
P25098 |
1 Reference(s) |
| T31QEZ | 5-hydroxytryptamine receptor 1A | HTR1A |
P08908 |
1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
4 Reference(s) |
| T64BED | 5-hydroxytryptamine receptor 2A | HTR2A |
P28223 |
1 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
4 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
19 Reference(s) |
| T83DDX | Endothelial protein C receptor | PROCR |
Q9UNN8 |
1 Reference(s) |
| T06VX0 | MAP/microtubule affinity-regulating kinase 4 | MARK4 |
Q96L34 |
2 Reference(s) |
| T24C0P | Bile acid receptor | NR1H4 |
Q96RI1 |
1 Reference(s) |
| T77TY2 | Protein disulfide-isomerase | P4HB |
P07237 |
1 Reference(s) |
| T20RA0 | Adenosine deaminase | ADA |
P00813 |
1 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
3 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
9 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
15 Reference(s) |
| T13Z69 | Solute carrier family 22 member 6 | SLC22A6 |
Q4U2R8 |
1 Reference(s) |
| T50PQ4 | Solute carrier family 22 member 8 | SLC22A8 |
Q8TCC7 |
1 Reference(s) |
| T97UTI | 6-phosphogluconate dehydrogenase, decarboxylating | PGD |
P52209 |
2 Reference(s) |
| T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
2 Reference(s) |
| T55L5P | Macrophage scavenger receptor types I and II | MSR1 |
P21757 |
1 Reference(s) |
| T08U92 | Mitochondrial brown fat uncoupling protein 1 | UCP1 |
P25874 |
2 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
4 Reference(s) |
| T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
2 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
23 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
6 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
5 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
3 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
4 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
5 Reference(s) |
| T20IHC | Diacylglycerol O-acyltransferase 1 | DGAT1 |
O75907 |
1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
6 Reference(s) |
| T16UZ4 | Dipeptidyl peptidase 4 | DPP4 |
P27487 |
1 Reference(s) |
| T64UWL | Taste receptor type 2 member 39 | TAS2R39 |
P59534 |
1 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
3 Reference(s) |
| T98RXH | Focal adhesion kinase 1 | PTK2 |
Q05397 |
2 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
2 Reference(s) |
| T53RK9 | T-cell surface glycoprotein CD4 | CD4 |
P01730 |
1 Reference(s) |
| T40GZM | Casein kinase II subunit alpha | CSNK2A1 |
P68400 |
1 Reference(s) |
| T96N1K | Calcium/calmodulin-dependent protein kinase type IV | CAMK4 |
Q16566 |
1 Reference(s) |
| T92HNO | High mobility group protein B1 | HMGB1 |
P09429 |
1 Reference(s) |
| T92E71 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11B2 |
P80365 |
2 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
9 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
4 Reference(s) |
| T04WT7 | Fibronectin | FN1 |
P02751 |
2 Reference(s) |
| T65S3S | Tyrosine-protein kinase JAK2 | JAK2 |
O60674 |
2 Reference(s) |
| T43QZ3 | Sclerostin | SOST |
Q9BQB4 |
1 Reference(s) |
| T60A9R | NA | CYP3A |
NA |
2 Reference(s) |
| T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
6 Reference(s) |
| T65JUB | Nucleotide-binding oligomerization domain-containing protein 2 | NOD2 |
Q9HC29 |
2 Reference(s) |
| T61J7T | Mothers against decapentaplegic homolog 2 | SMAD2 |
Q15796 |
1 Reference(s) |
| T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
2 Reference(s) |
| T09DI4 | Lysine-specific histone demethylase 1A | KDM1A |
O60341 |
1 Reference(s) |
| T73PLT | Sialidase-1 | NEU1 |
Q99519 |
1 Reference(s) |
| T32REB | Calcium/calmodulin-dependent protein kinase type II subunit gamma | CAMK2G |
Q13555 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
6 Reference(s) |
| T33JS5 | CCN family member 2 | CCN2 |
P29279 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
5 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
3 Reference(s) |
| T03CZ8 | Catechol O-methyltransferase | COMT |
P21964 |
3 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
5 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
12 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
3 Reference(s) |
| T41BXR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | SIRT3 |
Q9NTG7 |
7 Reference(s) |
| T83F53 | Forkhead box protein M1 | FOXM1 |
Q08050 |
1 Reference(s) |
| T45XTW | Retinoic acid receptor RXR-alpha | RXRA |
P19793 |
1 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
3 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
7 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
5 Reference(s) |
| T27IAF | Lactoylglutathione lyase | GLO1 |
Q04760 |
2 Reference(s) |
| T95A04 | Solute carrier organic anion transporter family member 2B1 | SLCO2B1 |
O94956 |
1 Reference(s) |
| T31YO2 | Solute carrier organic anion transporter family member 1A2 | SLCO1A2 |
P46721 |
1 Reference(s) |
| T92UWJ | Beta-2 adrenergic receptor | ADRB2 |
P07550 |
2 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
2 Reference(s) |
| T28WZ9 | Ribosyldihydronicotinamide dehydrogenase [quinone] | NQO2 |
P16083 |
2 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
1 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
4 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
4 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
3 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
9 Reference(s) |
| T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
2 Reference(s) |
| T05PKX | Steroid 17-alpha-hydroxylase/17,20 lyase | CYP17A1 |
P05093 |
2 Reference(s) |
| T53MV1 | cGMP-dependent protein kinase 1 | PRKG1 |
Q13976 |
1 Reference(s) |
| T95Y0K | Sphingosine kinase 1 | SPHK1 |
Q9NYA1 |
2 Reference(s) |
| T09KPZ | Vimentin | VIM |
P08670 |
1 Reference(s) |
| T54X6V | Intermediate conductance calcium-activated potassium channel protein 4 | KCNN4 |
O15554 |
2 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
1 Reference(s) |
| T96L4T | Krueppel-like factor 4 | KLF4 |
O43474 |
1 Reference(s) |
| T95GWW | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | PDE4A |
P27815 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
8 Reference(s) |
| T99V1T | Dynein heavy chain 8, axonemal | DNAH8 |
Q96JB1 |
1 Reference(s) |
| T68DAN | Histone deacetylase 9 | HDAC9 |
Q9UKV0 |
1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
| T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
1 Reference(s) |
| T39M81 | DNA-(apurinic or apyrimidinic site) endonuclease | APEX1 |
P27695 |
1 Reference(s) |
| T47YVM | Serine/threonine-protein kinase Sgk1 | SGK1 |
O00141 |
1 Reference(s) |
| T45LZI | Calcium release-activated calcium channel protein 1 | ORAI1 |
Q96D31 |
1 Reference(s) |
| T75A0Y | Citrate synthase, mitochondrial | CS |
O75390 |
1 Reference(s) |
| T39FBA | Thioredoxin-interacting protein | TXNIP |
Q9H3M7 |
2 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
1 Reference(s) |
| T70LAB | UDP-glucuronosyltransferase 1A9 | UGT1A9 |
O60656 |
1 Reference(s) |
| T67JR8 | Heat shock factor protein 1 | HSF1 |
Q00613 |
1 Reference(s) |
| T58K62 | Frataxin, mitochondrial | FXN |
Q16595 |
2 Reference(s) |
| T68XO1 | Indoleamine 2,3-dioxygenase 1 | IDO1 |
P14902 |
1 Reference(s) |
| T43SM9 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | PPARGC1A |
Q9UBK2 |
2 Reference(s) |
| T21CMG | Hepcidin | HAMP |
P81172 |
1 Reference(s) |
| T24D36 | Transcription factor A, mitochondrial | TFAM |
Q00059 |
1 Reference(s) |
| T74ETU | Steroid 21-hydroxylase | CYP21A2 |
P08686 |
1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
8 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
7 Reference(s) |
| T69XEM | Tyrosine-protein kinase SYK | SYK |
P43405 |
6 Reference(s) |
| T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
2 Reference(s) |
| T22J9V | Tyrosine-protein kinase JAK1 | JAK1 |
P23458 |
2 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
3 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
2 Reference(s) |
| T91N2D | Egl nine homolog 1 | EGLN1 |
Q9GZT9 |
1 Reference(s) |
| T86D6K | Polyunsaturated fatty acid lipoxygenase ALOX15 | ALOX15 |
P16050 |
9 Reference(s) |
| T48NTH | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | PIK3CD |
O00329 |
1 Reference(s) |
| T31JWV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | PIK3CB |
P42338 |
1 Reference(s) |
| T32SPJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | PIK3CG |
P48736 |
2 Reference(s) |
| T61SU2 | Coxsackievirus and adenovirus receptor | CXADR |
P78310 |
1 Reference(s) |
| T41INV | Nuclear receptor subfamily 1 group I member 3 | NR1I3 |
Q14994 |
1 Reference(s) |
| T71KM2 | TGF-beta receptor type-1 | TGFBR1 |
P36897 |
1 Reference(s) |
| T32JN2 | Beta-glucuronidase | GUSB |
P08236 |
2 Reference(s) |
| T15ZAV | Lymphocyte antigen 96 | LY96 |
Q9Y6Y9 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
12 Reference(s) |
| T58FWN | Tyrosine-protein kinase BTK | BTK |
Q06187 |
1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
2 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
16 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
1 Reference(s) |
| T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
2 Reference(s) |
| T84WE9 | Vascular endothelial growth factor receptor 1 | FLT1 |
P17948 |
1 Reference(s) |
| T29JZ3 | Vascular endothelial growth factor receptor 3 | FLT4 |
P35916 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
3 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
16 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
3 Reference(s) |
| T25RHJ | Sodium-dependent serotonin transporter | SLC6A4 |
P31645 |
1 Reference(s) |
| T78BSU | 5-hydroxytryptamine receptor 2B | HTR2B |
P41595 |
1 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
3 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
4 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
3 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
4 Reference(s) |
| T09KQF | Proliferating cell nuclear antigen | PCNA |
P12004 |
2 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
2 Reference(s) |
| T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
3 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
5 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
17 Reference(s) |
| T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
| T96DNP | Nucleic acid dioxygenase ALKBH1 | ALKBH1 |
Q13686 |
1 Reference(s) |
| T13HYI | Alpha-ketoglutarate-dependent dioxygenase FTO | FTO |
Q9C0B1 |
1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
3 Reference(s) |
| T97KL5 | Microsomal glutathione S-transferase 1 | MGST1 |
P10620 |
2 Reference(s) |
| T81BH5 | Sulfotransferase 1A1 | SULT1A1 |
P50225 |
2 Reference(s) |
| T36YWU | Kelch-like ECH-associated protein 1 | KEAP1 |
Q14145 |
1 Reference(s) |
| T92Q77 | Type I iodothyronine deiodinase | DIO1 |
P49895 |
1 Reference(s) |
| T99EYH | Lipoprotein lipase | LPL |
P06858 |
1 Reference(s) |
| T99W15 | Pancreatic triacylglycerol lipase | PNLIP |
P16233 |
1 Reference(s) |
| T86UXL | Cyclin-A2 | CCNA2 |
P20248 |
5 Reference(s) |
| T70SFS | Superoxide dismutase [Mn], mitochondrial | SOD2 |
P04179 |
2 Reference(s) |
| T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
3 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
2 Reference(s) |
| T18LPB | Cytochrome P450 11B2, mitochondrial | CYP11B2 |
P19099 |
1 Reference(s) |
| T70EJM | Eotaxin | CCL11 |
P51671 |
1 Reference(s) |
| T28PHS | Angiotensin-converting enzyme | ACE |
P12821 |
2 Reference(s) |
| T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
3 Reference(s) |
| T12PHR | Platelet glycoprotein VI | GP6 |
Q9HCN6 |
1 Reference(s) |
| T31SX8 | Bone morphogenetic protein 2 | BMP2 |
P12643 |
1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
2 Reference(s) |
| T01QZQ | Lengsin | LGSN |
Q5TDP6 |
1 Reference(s) |
| T02WMA | Ornithine decarboxylase | ODC1 |
P11926 |
1 Reference(s) |
| T51MC7 | Interleukin-17B | IL17B |
Q9UHF5 |
1 Reference(s) |
| T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
8 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
6 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
4 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
9 Reference(s) |
| T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
1 Reference(s) |
| T22IMH | Cyclin-dependent kinase 6 | CDK6 |
Q00534 |
2 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
14 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
3 Reference(s) |
| T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
3 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
3 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
| T36B1Q | Baculoviral IAP repeat-containing protein 5 | BIRC5 |
O15392 |
4 Reference(s) |
| T31EJG | Apoptotic protease-activating factor 1 | APAF1 |
O14727 |
1 Reference(s) |
| T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
1 Reference(s) |
| T81KAJ | X-ray repair cross-complementing protein 6 | XRCC6 |
P12956 |
1 Reference(s) |
| T86UJG | ATP-binding cassette sub-family C member 3 | ABCC3 |
O15438 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
1 Reference(s) |
| T23RWU | Type-1 angiotensin II receptor | AGTR1 |
P30556 |
1 Reference(s) |
| T28K6X | Insulin receptor substrate 1 | IRS1 |
P35568 |
2 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
3 Reference(s) |
| T74D4Y | CASP8 and FADD-like apoptosis regulator | CFLAR |
O15519 |
1 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
5 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
3 Reference(s) |
| T20W1O | C-C chemokine receptor type 2 | CCR2 |
P41597 |
1 Reference(s) |
| T67X1L | Eukaryotic translation initiation factor 2 subunit 1 | EIF2S1 |
P05198 |
1 Reference(s) |
| T47HTN | Prostaglandin E synthase | PTGES |
O14684 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
5 Reference(s) |
| T88QQE | Fibroblast growth factor 2 | FGF2 |
P09038 |
1 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
| T92LK2 | Tumor necrosis factor ligand superfamily member 10 | TNFSF10 |
P50591 |
2 Reference(s) |
| T40JMU | Glutamine synthetase | GLUL |
P15104 |
2 Reference(s) |
| T85K8L | Forkhead box protein O1 | FOXO1 |
Q12778 |
3 Reference(s) |
| T13NLM | Cell division control protein 42 homolog | CDC42 |
P60953 |
1 Reference(s) |
| T43BVC | Basigin | BSG |
P35613 |
1 Reference(s) |
| T15VAS | Integrin beta-1 | ITGB1 |
P05556 |
1 Reference(s) |
| T90QGN | T-cell-specific surface glycoprotein CD28 | CD28 |
P10747 |
1 Reference(s) |
| T23OTN | T-lymphocyte activation antigen CD80 | CD80 |
P33681 |
1 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
1 Reference(s) |
| T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
1 Reference(s) |
| T88LSZ | Aromatase | CYP19A1 |
P11511 |
1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
2 Reference(s) |
| T46NT6 | Cyclin-dependent kinase 7 | CDK7 |
P50613 |
1 Reference(s) |
| T62QDU | Alpha- and gamma-adaptin-binding protein p34 | AAGAB |
Q6PD74 |
1 Reference(s) |
| T88ER9 | Serine/threonine-protein kinase D1 | PRKD1 |
Q15139 |
1 Reference(s) |
| T29WP4 | Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha | TGFA |
P01135 |
1 Reference(s) |
| T08DOL | Sulfotransferase 1E1 | SULT1E1 |
P49888 |
1 Reference(s) |
| T01JSX | Carbonyl reductase [NADPH] 1 | CBR1 |
P16152 |
2 Reference(s) |
| T01QB9 | Integrin alpha-V | ITGAV |
P06756 |
2 Reference(s) |
| T27IR2 | Probable ATP-dependent RNA helicase DDX5 | DDX5 |
P17844 |
2 Reference(s) |
| T96ZVQ | RAC-beta serine/threonine-protein kinase | AKT2 |
P31751 |
1 Reference(s) |
| T53QS9 | Glutamate--cysteine ligase catalytic subunit | GCLC |
P48506 |
1 Reference(s) |
| T01Z6D | Leukotriene A-4 hydrolase | LTA4H |
P09960 |
1 Reference(s) |
| T32UXD | Leucine-rich repeats and immunoglobulin-like domains protein 1 | LRIG1 |
Q96JA1 |
1 Reference(s) |
| T69VYP | ATP-binding cassette sub-family G member 1 | ABCG1 |
P45844 |
1 Reference(s) |
| T04PM9 | Transthyretin | TTR |
P02766 |
1 Reference(s) |
| T06QUL | Fractalkine | CX3CL1 |
P78423 |
1 Reference(s) |
| T21YOI | Tyrosine--tRNA ligase, cytoplasmic | YARS1 |
P54577 |
1 Reference(s) |
| T18YXD | Albumin | ALB |
P02768 |
1 Reference(s) |
| T69ESY | Ras GTPase-activating protein-binding protein 1 | G3BP1 |
Q13283 |
1 Reference(s) |
| T30SFG | NA | MIR196B |
NA |
1 Reference(s) |
| T78MBM | Transcription factor 4 | TCF4 |
P15884 |
1 Reference(s) |
| T37PX5 | Zinc finger protein GLI1 | GLI1 |
P08151 |
3 Reference(s) |
| T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
1 Reference(s) |
| T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
1 Reference(s) |
| T93R42 | Dipeptidyl peptidase 1 | CTSC |
P53634 |
1 Reference(s) |
| T02QZI | NADPH oxidase 5 | NOX5 |
Q96PH1 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
2 Reference(s) |
| T87WH7 | Fos-related antigen 2 | FOSL2 |
P15408 |
2 Reference(s) |
| T16UHV | Nuclear factor of activated T-cells, cytoplasmic 1 | NFATC1 |
O95644 |
3 Reference(s) |
| T54N7G | Fos-related antigen 1 | FOSL1 |
P15407 |
1 Reference(s) |
| T35QZO | Cytochrome c | CYCS |
P99999 |
3 Reference(s) |
| T02P7Q | Dihydrofolate reductase | DHFR |
P00374 |
1 Reference(s) |
| T52CKD | Pro-epidermal growth factor | EGF |
P01133 |
1 Reference(s) |
| T42PUG | Solute carrier family 2, facilitated glucose transporter member 1 | SLC2A1 |
P11166 |
1 Reference(s) |
| T95K0K | Interferon alpha-1/13 | IFNA1; IFNA13 |
P01562 |
1 Reference(s) |
| T64LKA | Bile salt export pump | ABCB11 |
O95342 |
2 Reference(s) |
| T84CEG | Claudin-5 | CLDN5 |
O00501 |
1 Reference(s) |
| T30AEN | Aquaporin-5 | AQP5 |
P55064 |
2 Reference(s) |
| T47RAK | NA | MIR145 |
NA |
1 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
2 Reference(s) |
| T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
2 Reference(s) |
| T37SV3 | Occludin | OCLN |
Q16625 |
1 Reference(s) |
| T69F5W | Forkhead box protein D3 | FOXD3 |
Q9UJU5 |
1 Reference(s) |
| T13I7C | Transforming growth factor beta-2 proprotein | TGFB2 |
P61812 |
2 Reference(s) |
| T44EUX | Fragile X mental retardation syndrome-related protein 1 | FXR1 |
P51114 |
1 Reference(s) |
| T53Z7Y | Transcriptional coactivator YAP1 | YAP1 |
P46937 |
2 Reference(s) |
| T91MKC | Runt-related transcription factor 2 | RUNX2 |
Q13950 |
1 Reference(s) |
| T94H37 | Cadherin-1 | CDH1 |
P12830 |
3 Reference(s) |
| T73ZPO | Beta-casein | CSN2 |
P05814 |
1 Reference(s) |
| T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
| T15URL | Cathelicidin antimicrobial peptide | CAMP |
P49913 |
1 Reference(s) |
| T76TED | Pro-opiomelanocortin | POMC |
P01189 |
1 Reference(s) |
| T20E5P | Cytochrome b-245 heavy chain | CYBB |
P04839 |
1 Reference(s) |
| T67HXL | Glial cell line-derived neurotrophic factor | GDNF |
P39905 |
2 Reference(s) |
| T91MWA | Disintegrin and metalloproteinase domain-containing protein 17 | ADAM17 |
P78536 |
1 Reference(s) |
| T53TBQ | Elongation factor 2 | EEF2 |
P13639 |
1 Reference(s) |
| T13M0G | Protein S100-B | S100B |
P04271 |
1 Reference(s) |
| T34ZZ0 | Potassium channel subfamily K member 2 | KCNK2 |
O95069 |
1 Reference(s) |
| T87QUW | Actin, aortic smooth muscle | ACTA2 |
P62736 |
1 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
1 Reference(s) |
| T62Y4H | Protein kinase C epsilon type | PRKCE |
Q02156 |
1 Reference(s) |
| T54B00 | P2X purinoceptor 7 | P2RX7 |
Q99572 |
1 Reference(s) |
| T75EH8 | Glucagon-like peptide 1 receptor | GLP1R |
P43220 |
1 Reference(s) |
| T91UNL | Keratin, type I cytoskeletal 14 | KRT14 |
P02533 |
1 Reference(s) |
| T08B2M | M-phase inducer phosphatase 1 | CDC25A |
P30304 |
1 Reference(s) |
| T33UEM | Lactoperoxidase | LPO |
P22079 |
1 Reference(s) |
| T03TJ0 | Interleukin-33 | IL33 |
O95760 |
1 Reference(s) |
| T40G6B | Prostaglandin reductase 1 | PTGR1 |
Q14914 |
1 Reference(s) |
| T31VDH | Myeloid differentiation primary response protein MyD88 | MYD88 |
Q99836 |
1 Reference(s) |
| T00H7Q | Neutrophil cytosol factor 1 | NCF1 |
P14598 |
1 Reference(s) |
| T00EP2 | Tissue-type plasminogen activator | PLAT |
P00750 |
1 Reference(s) |
| T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
1 Reference(s) |
| T34DZ7 | Interleukin-2 | IL2 |
P60568 |
1 Reference(s) |
| T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
1 Reference(s) |
| T12PV0 | NA | MEG3 |
NA |
1 Reference(s) |
| T93YV8 | Tumor necrosis factor receptor superfamily member 11B | TNFRSF11B |
O00300 |
1 Reference(s) |
| T47G3X | Glucocorticoid receptor | NR3C1 |
P04150 |
1 Reference(s) |
| T08Q1T | Amiloride-sensitive sodium channel subunit alpha | SCNN1A |
P37088 |
1 Reference(s) |
| T77M4W | Adenosine receptor A2a | ADORA2A |
P29274 |
1 Reference(s) |
| T99ARN | Forkhead box protein P3 | FOXP3 |
Q9BZS1 |
1 Reference(s) |
| T39XYV | Dickkopf-related protein 1 | DKK1 |
O94907 |
1 Reference(s) |
| T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
1 Reference(s) |
| T80U0C | Glutathione synthetase | GSS |
P48637 |
1 Reference(s) |
| T84VZG | Ryanodine receptor 1 | RYR1 |
P21817 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
| T00OVG | Semaphorin-3A | SEMA3A |
Q14563 |
1 Reference(s) |
| T50DXZ | NA | MIR126 |
NA |
1 Reference(s) |
| T53KY7 | Cystic fibrosis transmembrane conductance regulator | CFTR |
P13569 |
1 Reference(s) |
| T28RI5 | Zinc finger E-box-binding homeobox 1 | ZEB1 |
P37275 |
1 Reference(s) |
| T02HSM | Neuroglobin | NGB |
Q9NPG2 |
1 Reference(s) |
| T38G9K | TNF receptor-associated factor 2 | TRAF2 |
Q12933 |
1 Reference(s) |
| T44BWE | Adiponectin receptor protein 2 | ADIPOR2 |
Q86V24 |
1 Reference(s) |
| T76B0A | Gap junction alpha-1 protein | GJA1 |
P17302 |
1 Reference(s) |
| T00YMY | Bcl-2-related protein A1 | BCL2A1 |
Q16548 |
1 Reference(s) |
| T42HTA | G1/S-specific cyclin-E2 | CCNE2 |
O96020 |
1 Reference(s) |
| T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
| T97VB6 | Adiponectin receptor protein 1 | ADIPOR1 |
Q96A54 |
1 Reference(s) |
| T63W0D | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638 |
1 Reference(s) |
| T02XPT | SPARC | SPARC |
P09486 |
1 Reference(s) |
| T45X9Z | Hepatocyte growth factor | HGF |
P14210 |
1 Reference(s) |
| T47WT6 | Breast cancer type 1 susceptibility protein | BRCA1 |
P38398 |
1 Reference(s) |
| T59EBF | Breast cancer type 2 susceptibility protein | BRCA2 |
P51587 |
1 Reference(s) |
| T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
2 Reference(s) |
| T28HOM | Leptin | LEP |
P41159 |
1 Reference(s) |
| T92EME | Membrane-bound transcription factor site-1 protease | MBTPS1 |
Q14703 |
1 Reference(s) |
| T55IBP | Zinc finger protein SNAI1 | SNAI1 |
O95863 |
1 Reference(s) |
| T50VJF | Osteopontin | SPP1 |
P10451 |
1 Reference(s) |
| T37G49 | Platelet-activating factor acetylhydrolase | PLA2G7 |
Q13093 |
1 Reference(s) |
| T00HDE | Parkinson disease protein 7 | PARK7 |
Q99497 |
1 Reference(s) |
| T53MUA | DNA-binding protein RFX5 | RFX5 |
P48382 |
1 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
1 Reference(s) |
| T70B7U | Angiotensin-converting enzyme 2 | ACE2 |
Q9BYF1 |
1 Reference(s) |
| T28HCY | Presenilin-1 | PSEN1 |
P49768 |
1 Reference(s) |
| T14JSQ | Baculoviral IAP repeat-containing protein 2 | BIRC2 |
Q13490 |
1 Reference(s) |
| T85NQ0 | NA | MALAT1 |
NA |
1 Reference(s) |
| T30UDV | Klotho | KL |
Q9UEF7 |
1 Reference(s) |
| T42GML | NA | MIR183 |
NA |
2 Reference(s) |
| T98JPP | Carnitine O-palmitoyltransferase 1, liver isoform | CPT1A |
P50416 |
1 Reference(s) |
| T67RBZ | Mitochondrial uncoupling protein 2 | UCP2 |
P55851 |
1 Reference(s) |
| T16IWB | Growth arrest and DNA damage-inducible protein GADD45 alpha | GADD45A |
P24522 |
1 Reference(s) |
| T07BRZ | E3 ubiquitin-protein ligase UHRF1 | UHRF1 |
Q96T88 |
1 Reference(s) |
| T53YWQ | Pro-neuropeptide Y [Cleaved into: Neuropeptide Y | NPY |
P01303 |
1 Reference(s) |
| T78EMM | Nuclear pore glycoprotein p62 | NUP62 |
P37198 |
1 Reference(s) |
| T35OPL | Sonic hedgehog protein | SHH |
Q15465 |
1 Reference(s) |
| T27LA6 | DNA | DNMT1 |
P26358 |
1 Reference(s) |
| T71GRQ | Hexokinase-2 | HK2 |
P52789 |
1 Reference(s) |
| T78PK3 | cAMP-dependent protein kinase catalytic subunit alpha | PRKACA |
P17612 |
1 Reference(s) |
| T16KVU | Tumor necrosis factor receptor superfamily member 1A | TNFRSF1A |
P19438 |
1 Reference(s) |
| T12IEI | Cadherin-2 | CDH2 |
P19022 |
1 Reference(s) |
| T80R6A | Insulin-like growth factor I | IGF1 |
P05019 |
1 Reference(s) |
| T06MQM | Heat shock protein beta-1 | HSPB1 |
P04792 |
1 Reference(s) |
| T83QKS | Regenerating islet-derived protein 3-alpha | REG3A |
Q06141 |
1 Reference(s) |
| T70EB9 | Nephrin | NPHS1 |
O60500 |
1 Reference(s) |
| T33FEZ | NA | MIR18A |
NA |
1 Reference(s) |
| T75CHS | NA | MIR15A |
NA |
1 Reference(s) |
| T08JAV | Phosphatidate phosphatase LPIN1 | LPIN1 |
Q14693 |
1 Reference(s) |
| T38EXQ | Profilin-1 | PFN1 |
P07737 |
1 Reference(s) |
| T16S8T | Baculoviral IAP repeat-containing protein 7 | BIRC7 |
Q96CA5 |
1 Reference(s) |
| T31G6V | Ras association domain-containing protein 1 | RASSF1 |
Q9NS23 |
1 Reference(s) |
| T26RYP | CD83 antigen | CD83 |
Q01151 |
1 Reference(s) |
| T84FSA | Forkhead box protein O3 | FOXO3 |
O43524 |
1 Reference(s) |
| T28IEO | Podocin | NPHS2 |
Q9NP85 |
1 Reference(s) |
| T43LYL | X-box-binding protein 1 | XBP1 |
P17861 |
1 Reference(s) |
| T47MPW | T-lymphocyte activation antigen CD86 | CD86 |
P42081 |
1 Reference(s) |
| T40NB1 | Ribosomal protein S6 kinase beta-1 | RPS6KB1 |
P23443 |
1 Reference(s) |
| T72QH0 | Eukaryotic translation initiation factor 4E-binding protein 1 | EIF4EBP1 |
Q13541 |
1 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
2 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
2 Reference(s) |
| T18CUI | Neuron-specific calcium-binding protein hippocalcin | HPCA |
P84074 |
1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
1 Reference(s) |
| T08SJX | Astrocytic phosphoprotein PEA-15 | PEA15 |
Q15121 |
1 Reference(s) |
| T38OQ4 | Peroxiredoxin-2 | PRDX2 |
P32119 |
1 Reference(s) |
| T38J3Y | Gamma-enolase | ENO2 |
P09104 |
1 Reference(s) |
| T95H9O | Stromelysin-2 | MMP10 |
P09238 |
1 Reference(s) |
| T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
| T87C5Q | Polyunsaturated fatty acid lipoxygenase ALOX12 | ALOX12 |
P18054 |
1 Reference(s) |
| T10KMJ | Insulin-like growth factor II | IGF2 |
P01344 |
1 Reference(s) |
| T54WR0 | Fatty acid-binding protein 5 | FABP5 |
Q01469 |
1 Reference(s) |
| T58TOI | Apolipoprotein D | APOD |
P05090 |
1 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
1 Reference(s) |
| T68OIU | CREB-regulated transcription coactivator 1 | CRTC1 |
Q6UUV9 |
1 Reference(s) |
| T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
1 Reference(s) |
| T49XOZ | Krueppel-like factor 7 | KLF7 |
O75840 |
1 Reference(s) |
Related Compounds (Total: 31)
C0041
Name: Emodin
C0397
Name: Serotonin
C0377
Name: Rutin
C0881
Name: Aloe-Emodin
C0306
Name: Physcion
key description of the interaction between compound and target