Target Description

Type Detail
Target ID T85K8L
Protein Name Forkhead box protein O1
Uniprot ID Q12778
Protein Name Alias Forkhead box protein O1A;  Forkhead in rhabdomyosarcoma
Gene ID 2308
Gene Symbol FOXO1
Gene Alias FKHR;  FOXO1A
TTD T72850: Research target
Pfam PF16675 ; PF16676 ; PF00250
GO
2000074:regulation of type B pancreatic cell development

0070542:response to fatty acid

0051721:protein phosphatase 2A binding

0006974:cellular response to DNA damage stimulus

0008013:beta-catenin binding

0008286:insulin receptor signaling pathway

0031625:ubiquitin protein ligase binding

0045732:positive regulation of protein catabolic process

0070417:cellular response to cold

0070301:cellular response to hydrogen peroxide

0006914:autophagy

0043066:negative regulation of apoptotic process

0009267:cellular response to starvation

0003682:chromatin binding

0001659:temperature homeostasis

0045599:negative regulation of fat cell differentiation

0005829:cytosol

0045444:fat cell differentiation

0043065:positive regulation of apoptotic process

0097009:energy homeostasis

0070166:enamel mineralization

1903243:negative regulation of cardiac muscle hypertrophy in response to stress

0006915:apoptotic process

0010508:positive regulation of autophagy

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0001223:transcription coactivator binding

0071549:cellular response to dexamethasone stimulus

0005654:nucleoplasm

0043565:sequence-specific DNA binding

0071732:cellular response to nitric oxide

0005737:cytoplasm

0045893:positive regulation of transcription, DNA-templated

0032873:negative regulation of stress-activated MAPK cascade

0000785:chromatin

0005739:mitochondrion

0003700:DNA-binding transcription factor activity

0032869:cellular response to insulin stimulus

0034599:cellular response to oxidative stress

0045944:positive regulation of transcription by RNA polymerase II

0005634:nucleus

0001678:cellular glucose homeostasis

0019221:cytokine-mediated signaling pathway

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0071455:cellular response to hyperoxia

1902617:response to fluoride

0045892:negative regulation of transcription, DNA-templated

0006473:protein acetylation

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

PDB 6QZS ; 6QZR ; 4LG0 ; 3CO6 ; 3COA ; 5DUI ; 6QVW ; 3CO7
Drugbank NA
KEGG hsa:2308

Related Compounds  (Total: 7)

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C0213
Name: Metformin
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C0238
Name: Nandrolone
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C0325
Name: Progesterone
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C0363
Name: Resveratrol
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C0553
Name: Betaine


Related Herbs  (Total: 42)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0357 Ren Shen人参 GinsengPanax ginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0416 Shan Shen山参 NAPanax ginseng
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0970 Di Gu Pi地骨皮 root - bark of chinese wolfberryCortex lycii radicis
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum