HIT-result

Target Description

Type	Detail
Target ID	T85K8L
Protein Name	Forkhead box protein O1
Uniprot ID	Q12778
Protein Name Alias	Forkhead box protein O1A; Forkhead in rhabdomyosarcoma
Gene ID	2308
Gene Symbol	FOXO1
Gene Alias	FKHR; FOXO1A
TTD	T72850: Research target
Pfam	PF16675 ; PF16676 ; PF00250
GO	2000074:regulation of type B pancreatic cell development 0070542:response to fatty acid 0051721:protein phosphatase 2A binding 0006974:cellular response to DNA damage stimulus 0008013:beta-catenin binding 0008286:insulin receptor signaling pathway 0031625:ubiquitin protein ligase binding 0045732:positive regulation of protein catabolic process 0070417:cellular response to cold 0070301:cellular response to hydrogen peroxide 0006914:autophagy 0043066:negative regulation of apoptotic process 0009267:cellular response to starvation 0003682:chromatin binding 0001659:temperature homeostasis 0045599:negative regulation of fat cell differentiation 0005829:cytosol 0045444:fat cell differentiation 0043065:positive regulation of apoptotic process 0097009:energy homeostasis 0070166:enamel mineralization 1903243:negative regulation of cardiac muscle hypertrophy in response to stress 0006915:apoptotic process 0010508:positive regulation of autophagy 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0001223:transcription coactivator binding 0071549:cellular response to dexamethasone stimulus 0005654:nucleoplasm 0043565:sequence-specific DNA binding 0071732:cellular response to nitric oxide 0005737:cytoplasm 0045893:positive regulation of transcription, DNA-templated 0032873:negative regulation of stress-activated MAPK cascade 0000785:chromatin 0005739:mitochondrion 0003700:DNA-binding transcription factor activity 0032869:cellular response to insulin stimulus 0034599:cellular response to oxidative stress 0045944:positive regulation of transcription by RNA polymerase II 0005634:nucleus 0001678:cellular glucose homeostasis 0019221:cytokine-mediated signaling pathway 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0071455:cellular response to hyperoxia 1902617:response to fluoride 0045892:negative regulation of transcription, DNA-templated 0006473:protein acetylation 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0006357:regulation of transcription by RNA polymerase II
PDB	6QZS ; 6QZR ; 4LG0 ; 3CO6 ; 3COA ; 5DUI ; 6QVW ; 3CO7
Drugbank	NA
KEGG	hsa:2308

Type

Detail

Target ID

T85K8L

Protein Name

Forkhead box protein O1

Uniprot ID

Q12778

Protein Name Alias

Forkhead box protein O1A; Forkhead in rhabdomyosarcoma

Gene ID

2308

Gene Symbol

FOXO1

Gene Alias

FKHR; FOXO1A

TTD

T72850: Research target

Pfam

PF16675 ; PF16676 ; PF00250

2000074:regulation of type B pancreatic cell development

0070542:response to fatty acid

0051721:protein phosphatase 2A binding

0006974:cellular response to DNA damage stimulus

0008013:beta-catenin binding

0008286:insulin receptor signaling pathway

0031625:ubiquitin protein ligase binding

0045732:positive regulation of protein catabolic process

0070417:cellular response to cold

0070301:cellular response to hydrogen peroxide

0006914:autophagy

0043066:negative regulation of apoptotic process

0009267:cellular response to starvation

0003682:chromatin binding

0001659:temperature homeostasis

0045599:negative regulation of fat cell differentiation

0005829:cytosol

0045444:fat cell differentiation

0043065:positive regulation of apoptotic process

0097009:energy homeostasis

0070166:enamel mineralization

1903243:negative regulation of cardiac muscle hypertrophy in response to stress

0006915:apoptotic process

0010508:positive regulation of autophagy

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0001223:transcription coactivator binding

0071549:cellular response to dexamethasone stimulus

0005654:nucleoplasm

0043565:sequence-specific DNA binding

0071732:cellular response to nitric oxide

0005737:cytoplasm

0045893:positive regulation of transcription, DNA-templated

0032873:negative regulation of stress-activated MAPK cascade

0000785:chromatin

0005739:mitochondrion

0003700:DNA-binding transcription factor activity

0032869:cellular response to insulin stimulus

0034599:cellular response to oxidative stress

0045944:positive regulation of transcription by RNA polymerase II

0005634:nucleus

0001678:cellular glucose homeostasis

0019221:cytokine-mediated signaling pathway

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0071455:cellular response to hyperoxia

1902617:response to fluoride

0045892:negative regulation of transcription, DNA-templated

0006473:protein acetylation

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

PDB

6QZS ; 6QZR ; 4LG0 ; 3CO6 ; 3COA ; 5DUI ; 6QVW ; 3CO7

Drugbank

KEGG

hsa:2308

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0970	Di Gu Pi	地骨皮	root - bark of chinese wolfberry	Cortex lycii radicis
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0416	Shan Shen	山参	NA	Panax ginseng
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa

Target Description

Related Compounds (Total: 7)

Related Herbs (Total: 42)