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Compound Description

ID:   C0213 Common name:   Metformin
IUPAC:  3-(diaminomethylidene)-1,1-dimethylguanidine CAS:  CAS:657-24-9
Chembl ID:   CHEMBL1431 Pubchem ID:   CID:4091
Formula:  C4H11N5 TCM-ID:  TCMC1549
Smiles:  CN(C(=N)NC(=N)N)C
Alias:

Biguanide, 1,1-dimethyl-;

N,N-Dimethylimidodicarbonimidic diamide;

1,1-Dimethylbiguanide;

1-Carbamimidamido-N,N-dimethylmethanimidamide;

1-[Amino(dimethylamino)methylidene]guanidine;

Cidophage;

DMGG;

Dimethylbiguanide;

Emiphage;

Ficonax;

Fluamine;

Flumamine;

Glifor;

Gliguanid;

Glucofine;

Haurymelin;

Metformin;

Metiguanide;

Metphage;

N,N-Dimethylbiguanide;

N,N-Dimethyldiguanide;

N1,N1-Dimethylbiguanide;

NNDG;

N'-Dimethylguanylguanidine;

Siofor;

[[Amino(dimethylamino)methylidene]amino]methanimidamide
Structure:

Related Targets  (Total: 100)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
 A 16 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
 A 2 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
 A 3 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 A 3 Reference(s)
T02DEN Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptideGCG P01275
 A 2 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
 A 3 Reference(s)
T16UZ4 Dipeptidyl peptidase 4DPP4 P27487
 A 2 Reference(s)
T33OSQ Sterol regulatory element-binding protein 1SREBF1 P36956
 A 1 Reference(s)
T96YED Integrin-linked protein kinaseILK Q13418
 A 1 Reference(s)
T88LSZ AromataseCYP19A1 P11511
 A 1 Reference(s)
T59ZYY NUAK family SNF1-like kinase 2NUAK2 Q9H093
 A 1 Reference(s)
T84FSA Forkhead box protein O3FOXO3 O43524
 A 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
 A 1 Reference(s)
T25Y64 CholinesteraseBCHE P06276
 A 1 Reference(s)
T37HPX Apolipoprotein A-VAPOA5 Q6Q788
 A 1 Reference(s)
T52CNR Glutaminase kidney isoform, mitochondrialGLS O94925
 A 1 Reference(s)
T63FKF Protein lin-28 homolog ALIN28A Q9H9Z2
 A 1 Reference(s)
T86FO6 Protein lin-28 homolog BLIN28B Q6ZN17
 A 1 Reference(s)
T24VJT GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenaseH6PD O95479
 A 1 Reference(s)
T47F48 Cytochrome P450 4F3CYP4F3 Q08477
 A 1 Reference(s)
T58CAO Alpha-synucleinSNCA P37840
 A 1 Reference(s)
T48DQY Sodium/glucose cotransporter 2SLC5A2 P31639
 A 1 Reference(s)
T58TFI 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3PFKFB3 Q16875
 A 1 Reference(s)
T52RGZ Growth/differentiation factor 15GDF15 Q99988
 A 1 Reference(s)
T77A47 Eukaryotic translation initiation factor 4EEIF4E P06730
 A 1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
 A 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
 A 1 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
 A 1 Reference(s)
T92UBJ Acetyl-CoA carboxylase 1ACACA Q13085
 A 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
 A 1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
 A 1 Reference(s)
T92HNO High mobility group protein B1HMGB1 P09429
 B 1 Reference(s)
T68OIU CREB-regulated transcription coactivator 1CRTC1 Q6UUV9
 B 1 Reference(s)
T71PTC Protein kinase C iota typePRKCI P41743
 B 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
 B 4 Reference(s)
T39WPZ Mitogen-activated protein kinase 9MAPK9 P45984
 B 1 Reference(s)
T61J7T Mothers against decapentaplegic homolog 2SMAD2 Q15796
 B 1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
 B 1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
 C 1 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
 C 1 Reference(s)
T32TMS Serine/threonine-protein kinase NLKNLK Q9UBE8
 C 2 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
 C 3 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
 C 1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
 C 1 Reference(s)
T32EIL F-box only protein 32FBXO32 Q969P5
 C 1 Reference(s)
T67RBZ Mitochondrial uncoupling protein 2UCP2 P55851
 C 1 Reference(s)
T10S5F Cyclin-dependent kinase 4CDK4 P11802
 C 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
 C 3 Reference(s)
T50SG1 Glycerol-3-phosphate dehydrogenase, mitochondrialGPD2 P43304
 C 2 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
 C 4 Reference(s)
T64UH1 Nitric oxide synthase, endothelialNOS3 P29474
 C 1 Reference(s)
T85K8L Forkhead box protein O1FOXO1 Q12778
 C 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 C 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
 C 1 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
 C 2 Reference(s)
T75EH8 Glucagon-like peptide 1 receptorGLP1R P43220
 C 1 Reference(s)
T27IAF Lactoylglutathione lyaseGLO1 Q04760
 C 3 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
 C 2 Reference(s)
T22IMH Cyclin-dependent kinase 6CDK6 Q00534
 C 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
 C 1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
 C 1 Reference(s)
T16GZN Muellerian-inhibiting factorAMH P03971
 C 1 Reference(s)
T95IYZ AdiponectinADIPOQ Q15848
 C 1 Reference(s)
T55WN8 Proteinase-activated receptor 2F2RL1 P55085
 C 1 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
 C 1 Reference(s)
T17CNB ThioredoxinTXN P10599
 C 1 Reference(s)
T53B9U Protein mono-ADP-ribosyltransferase TIPARPTIPARP Q7Z3E1
 C 1 Reference(s)
T88P76 DNA excision repair protein ERCC-1ERCC1 P07992
 C 1 Reference(s)
T41BXR NAD-dependent protein deacetylase sirtuin-3, mitochondrialSIRT3 Q9NTG7
 C 1 Reference(s)
T54SRL Chloride intracellular channel protein 1CLIC1 O00299
 C 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
 C 2 Reference(s)
T95EGR Collagen alpha-1(II) chainCOL2A1 P02458
 C 1 Reference(s)
T81WQN Aggrecan core proteinACAN P16112
 C 1 Reference(s)
T50ISX Inositol polyphosphate multikinaseIPMK Q8NFU5
 C 1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
 C 1 Reference(s)
T71V6E Serine/threonine-protein kinase PAK 1PAK1 Q13153
 C 1 Reference(s)
T37VPC Homeobox protein NANOGNANOG Q9H9S0
 C 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 C 1 Reference(s)
T86YQL ProlactinPRL P01236
 C 1 Reference(s)
T80SD7 Sterol regulatory element-binding protein 2SREBF2 Q12772
 C 1 Reference(s)
T84CPO Pigment epithelium-derived factorSERPINF1 P36955
 C 1 Reference(s)
T96HZ7 Retinoic acid receptor responder protein 2RARRES2 Q99969
 C 1 Reference(s)
T47BNM Solute carrier family 22 member 1SLC22A1 O15245
 C 1 Reference(s)
T64MZG Tribbles homolog 3TRIB3 Q96RU7
 C 1 Reference(s)
T17AMT NAMIR34A NA
 C 1 Reference(s)
T68V21 NAMIR26A1 NA
 C 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
 C 1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
 C 1 Reference(s)
T90IQF NAHULC NA
 C 1 Reference(s)
T95Y0K Sphingosine kinase 1SPHK1 Q9NYA1
 C 1 Reference(s)
T23F6L Transcription factor HES-3HES3 Q5TGS1
 C 1 Reference(s)
T51WGR Pancreas/duodenum homeobox protein 1PDX1 P52945
 C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 C 1 Reference(s)
T15JRW Interferon alpha-inducible protein 27, mitochondrialIFI27 P40305
 C 1 Reference(s)
T04WTG Mitogen-activated protein kinase 10MAPK10 P53779
 C 1 Reference(s)
T56OMG Fibulin-1FBLN1 P23142
 C 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
 C 1 Reference(s)
T53FF1 S-phase kinase-associated protein 2SKP2 Q13309
 C 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
 C 1 Reference(s)
T97ESI Apolipoprotein EAPOE P02649
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens

Ckey description of the interaction between compound and target


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