Target Description

Type Detail
Target ID T61J7T
Protein Name Mothers against decapentaplegic homolog 2
Uniprot ID Q15796
Protein Name Alias MAD homolog 2;  Mothers against DPP homolog 2;  JV18-1;  Mad-related protein 2;  hMAD-2;  SMAD family member 2;  SMAD 2;  Smad2;  hSMAD2
Gene ID 4087
Gene Symbol SMAD2
Gene Alias MADH2;  MADR2
TTD NA
Pfam PF03166 ; PF03165
GO
0033613:activating transcription factor binding

0046872:metal ion binding

0048617:embryonic foregut morphogenesis

0032991:protein-containing complex

0003690:double-stranded DNA binding

0016579:protein deubiquitination

0034713:type I transforming growth factor beta receptor binding

0023019:signal transduction involved in regulation of gene expression

0097718:disordered domain specific binding

0000987:cis-regulatory region sequence-specific DNA binding

0032444:activin responsive factor complex

0009952:anterior/posterior pattern specification

0048340:paraxial mesoderm morphogenesis

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0008134:transcription factor binding

0009749:response to glucose

0009653:anatomical structure morphogenesis

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0005737:cytoplasm

0030325:adrenal gland development

0060039:pericardium development

0005829:cytosol

0035019:somatic stem cell population maintenance

0005654:nucleoplasm

0045944:positive regulation of transcription by RNA polymerase II

0032924:activin receptor signaling pathway

0035556:intracellular signal transduction

0008285:negative regulation of cell population proliferation

0048156:tau protein binding

0071141:SMAD protein complex

0007179:transforming growth factor beta receptor signaling pathway

0070410:co-SMAD binding

0045165:cell fate commitment

0007182:common-partner SMAD protein phosphorylation

0007183:SMAD protein complex assembly

0031625:ubiquitin protein ligase binding

0007352:zygotic specification of dorsal/ventral axis

0003700:DNA-binding transcription factor activity

0030324:lung development

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0045892:negative regulation of transcription, DNA-templated

0051098:regulation of binding

0035265:organ growth

0060395:SMAD protein signal transduction

0030073:insulin secretion

0001707:mesoderm formation

0038092:nodal signaling pathway

0000122:negative regulation of transcription by RNA polymerase II

0062009:secondary palate development

0046332:SMAD binding

0005160:transforming growth factor beta receptor binding

0070411:I-SMAD binding

0042060:wound healing

0070412:R-SMAD binding

0005667:transcription regulator complex

0005634:nucleus

0009791:post-embryonic development

0019902:phosphatase binding

0070723:response to cholesterol

0001706:endoderm formation

1900224:positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

0071144:heteromeric SMAD protein complex

0007369:gastrulation

0010718:positive regulation of epithelial to mesenchymal transition

0048701:embryonic cranial skeleton morphogenesis

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0030154:cell differentiation

0045893:positive regulation of transcription, DNA-templated

0003682:chromatin binding

0001701:in utero embryonic development

0017015:regulation of transforming growth factor beta receptor signaling pathway

0031016:pancreas development

0031053:primary miRNA processing

0030513:positive regulation of BMP signaling pathway

0001657:ureteric bud development

0030509:BMP signaling pathway

0000785:chromatin

PDB 6M64 ; 7CO1 ; 2LB3 ; 1U7V ; 5XOD ; 1DEV ; 1KHX ; 5ZOJ
Drugbank DB04522
KEGG hsa:4087

Related Compounds  (Total: 8)

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C0055
Name: Estradiol
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C0213
Name: Metformin
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C0406
Name: Simvastatin
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C0700
Name: Ginsenoside Rg1
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C0721
Name: Baicalin


Related Herbs  (Total: 94)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0017 Ji Xue Teng鸡血藤 Suberect spatholobus stemSpatholobus suberectus
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0018 Ji Xue Teng Gan Gao鸡血藤干膏 Suberect spatholobus stemSpatholobus suberectus
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0981 Dian Ji Xue Teng Gao Fen滇鸡血藤膏粉 Suberect spatholobus stemSpatholobus suberectus
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0561 Tong Ji Li潼蒺藜 Flatstem milkvetch seedSemen astragali complanati
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0401 Sha Yuan Ji Li沙苑蒺藜 Seed of flaststem milkvetchSemen astragali complanati
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0019 Ji Xue Teng Gao鸡血藤膏 Suberect spatholobus stemSpatholobus suberectus
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H0077 Jiu EthanolVinum
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1227 Huai Zhi槐枝 NASophora japonica
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0631 Xi Yang Shen西洋参 American ginsengPanax quinquefolium
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H1225 Huai Mi槐米 NASophora japonica
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0357 Ren Shen人参 GinsengPanax ginseng
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0402 Sha Yuan Zi沙苑子 Flatstem milkvetch seedSemen astragali complanati
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0527 Tao PeachPrunus persica
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H1142 Guo Jiang Long过江龙 Complanate clubmossMillettia dielsiana
H0378 San Qi三七 SanchiPanax notoginseng
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H1021 E Da Xia莪大夏 NAOxytropis falcata
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum