HIT-result

Type	Detail
Target ID	T61J7T
Protein Name	Mothers against decapentaplegic homolog 2
Uniprot ID	Q15796
Protein Name Alias	MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
Gene ID	4087
Gene Symbol	SMAD2
Gene Alias	MADH2; MADR2
TTD	NA
Pfam	PF03166 ; PF03165
GO	0033613:activating transcription factor binding 0046872:metal ion binding 0048617:embryonic foregut morphogenesis 0032991:protein-containing complex 0003690:double-stranded DNA binding 0016579:protein deubiquitination 0034713:type I transforming growth factor beta receptor binding 0023019:signal transduction involved in regulation of gene expression 0097718:disordered domain specific binding 0000987:cis-regulatory region sequence-specific DNA binding 0032444:activin responsive factor complex 0009952:anterior/posterior pattern specification 0048340:paraxial mesoderm morphogenesis 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0008134:transcription factor binding 0009749:response to glucose 0009653:anatomical structure morphogenesis 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0005737:cytoplasm 0030325:adrenal gland development 0060039:pericardium development 0005829:cytosol 0035019:somatic stem cell population maintenance 0005654:nucleoplasm 0045944:positive regulation of transcription by RNA polymerase II 0032924:activin receptor signaling pathway 0035556:intracellular signal transduction 0008285:negative regulation of cell population proliferation 0048156:tau protein binding 0071141:SMAD protein complex 0007179:transforming growth factor beta receptor signaling pathway 0070410:co-SMAD binding 0045165:cell fate commitment 0007182:common-partner SMAD protein phosphorylation 0007183:SMAD protein complex assembly 0031625:ubiquitin protein ligase binding 0007352:zygotic specification of dorsal/ventral axis 0003700:DNA-binding transcription factor activity 0030324:lung development 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0045892:negative regulation of transcription, DNA-templated 0051098:regulation of binding 0035265:organ growth 0060395:SMAD protein signal transduction 0030073:insulin secretion 0001707:mesoderm formation 0038092:nodal signaling pathway 0000122:negative regulation of transcription by RNA polymerase II 0062009:secondary palate development 0046332:SMAD binding 0005160:transforming growth factor beta receptor binding 0070411:I-SMAD binding 0042060:wound healing 0070412:R-SMAD binding 0005667:transcription regulator complex 0005634:nucleus 0009791:post-embryonic development 0019902:phosphatase binding 0070723:response to cholesterol 0001706:endoderm formation 1900224:positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry 0071144:heteromeric SMAD protein complex 0007369:gastrulation 0010718:positive regulation of epithelial to mesenchymal transition 0048701:embryonic cranial skeleton morphogenesis 0030512:negative regulation of transforming growth factor beta receptor signaling pathway 0030154:cell differentiation 0045893:positive regulation of transcription, DNA-templated 0003682:chromatin binding 0001701:in utero embryonic development 0017015:regulation of transforming growth factor beta receptor signaling pathway 0031016:pancreas development 0031053:primary miRNA processing 0030513:positive regulation of BMP signaling pathway 0001657:ureteric bud development 0030509:BMP signaling pathway 0000785:chromatin
PDB	6M64 ; 7CO1 ; 2LB3 ; 1U7V ; 5XOD ; 1DEV ; 1KHX ; 5ZOJ
Drugbank	DB04522
KEGG	hsa:4087

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Name: Estradiol

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Name: Metformin

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Name: Simvastatin

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Name: Ginsenoside Rg1

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Name: Baicalin

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0019	Ji Xue Teng Gao	鸡血藤膏	Suberect spatholobus stem	Spatholobus suberectus
H0198	Ma Huang Gao	麻黄膏	Chinese ephedra	Ephedra sinica
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0981	Dian Ji Xue Teng Gao Fen	滇鸡血藤膏粉	Suberect spatholobus stem	Spatholobus suberectus
H0401	Sha Yuan Ji Li	沙苑蒺藜	Seed of flaststem milkvetch	Semen astragali complanati
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H1142	Guo Jiang Long	过江龙	Complanate clubmoss	Millettia dielsiana
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0429	Shao Yao	芍药	Red peony root	Paeonia obovata
H0402	Sha Yuan Zi	沙苑子	Flatstem milkvetch seed	Semen astragali complanati
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1021	E Da Xia	莪大夏	NA	Oxytropis falcata
H0246	Mi Ma Huang	蜜麻黄	Ephedra equisetin	Ephedra sinica
H0077	Jiu	酒	Ethanol	Vinum
H0527	Tao	桃	Peach	Prunus persica
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0650	Chai Hu	柴胡	Chinese thorowax	Bupleurum chinense
H0714	Yan Tai Chai Hu	烟台柴胡	Chinese thorowax	Bupleurum chinense
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H1225	Huai Mi	槐米	NA	Sophora japonica
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0018	Ji Xue Teng Gan Gao	鸡血藤干膏	Suberect spatholobus stem	Spatholobus suberectus
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0378	San Qi	三七	Sanchi	Panax notoginseng
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0965	Deng Zhan Xi Xin	灯盏细辛	Shortscape fleabane	Erigeron breviscapus
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0631	Xi Yang Shen	西洋参	American ginseng	Panax quinquefolium
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0200	Ma Huang Gen	麻黄根	Chinese ephedra root	Ephedra sinica
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0561	Tong Ji Li	潼蒺藜	Flatstem milkvetch seed	Semen astragali complanati
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0665	Chai Hu Shao	柴胡梢	Chinese thorowax	Bupleurum chinense
H0201	Ma Huang Jin Gao	麻黄浸膏	Chinese ephedra	Ephedra sinica
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H0957	Dang Gui Teng	当归藤	NA	Embelia parviflora
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0784	Chi Shao	赤芍	Red peony root	Paeonia obovata
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0155	Ban Xia	半夏	Ternate pinellia	Pinellia ternata
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0197	Ma Huang	麻黄	Chinese ephedra	Ephedra sinica
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H0826	Chu Mu Dan	臭牡丹	rose glorybower	Clerodendrum bungei
H0017	Ji Xue Teng	鸡血藤	Suberect spatholobus stem	Spatholobus suberectus
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H0659	Chai Hu Jin Gao	柴胡浸膏	Chinese thorowax	Bupleurum chinense
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata

Target Description

Related Compounds (Total: 8)

Related Herbs (Total: 94)