Herb Description

Herb ID:   H1102 Chinese Character:   骨碎补
English Name:  Fortune’s drynaria rhizome Latin Name:  Drynaria fortunei
Chinese Pin Yin :  Gu Sui Bu TCM-ID:  TCMH700
Therapeutic Function in Chinese :  活血化淤 Therapeutic Function in English:  Blood activation and stasis removal
Herb Function:  Replenish the kidney, strengthen the bones, promote the healing of fracture, and relieve pain

Related Targets  (Total: 231)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T80PUR Caspase-7CASP7 P55210
1 Reference(s)
T25NS3 Caspase-6CASP6 P55212
1 Reference(s)
T85U8U Caspase-3CASP3 P42574
12 Reference(s)
T38T1U Caspase-8CASP8 Q14790
2 Reference(s)
T01QLH Estrogen receptorESR1 P03372
7 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
8 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
1 Reference(s)
T86CQC Glutamate receptor ionotropic, NMDA 1GRIN1 Q05586
1 Reference(s)
T57MP0 ChymaseCMA1 P23946
1 Reference(s)
T86YQL ProlactinPRL P01236
1 Reference(s)
T61NZN Progonadoliberin-1GNRH1 P01148
1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
2 Reference(s)
T91MKC Runt-related transcription factor 2RUNX2 Q13950
1 Reference(s)
T70HTD Cytochrome P450 2E1CYP2E1 P05181
1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
3 Reference(s)
T73LXA Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1BHSPA1A;HSPA1B P0DMV8;P0DMV9
1 Reference(s)
T98RXH Focal adhesion kinase 1PTK2 Q05397
2 Reference(s)
T12PIB Lysosomal alpha-glucosidaseGAA P10253
1 Reference(s)
T53RK9 T-cell surface glycoprotein CD4CD4 P01730
1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
3 Reference(s)
T23P74 Caspase-9CASP9 P55211
5 Reference(s)
T04H8Y Beta-secretase 1BACE1 P56817
1 Reference(s)
T06VX0 MAP/microtubule affinity-regulating kinase 4MARK4 Q96L34
1 Reference(s)
T54G8J Protein kinase C delta typePRKCD Q05655
2 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
3 Reference(s)
T20IHC Diacylglycerol O-acyltransferase 1DGAT1 O75907
1 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
1 Reference(s)
T16UZ4 Dipeptidyl peptidase 4DPP4 P27487
1 Reference(s)
T03CZ8 Catechol O-methyltransferaseCOMT P21964
3 Reference(s)
T64UH1 Nitric oxide synthase, endothelialNOS3 P29474
4 Reference(s)
T50SJ8 5'-AMP-activated protein kinase catalytic subunit alpha-2PRKAA2 P54646
1 Reference(s)
T57L0X Oxysterols receptor LXR-alphaNR1H3 Q13133
1 Reference(s)
T25Y64 CholinesteraseBCHE P06276
2 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
2 Reference(s)
T27IAF Lactoylglutathione lyaseGLO1 Q04760
1 Reference(s)
T95A04 Solute carrier organic anion transporter family member 2B1SLCO2B1 O94956
1 Reference(s)
T31YO2 Solute carrier organic anion transporter family member 1A2SLCO1A2 P46721
1 Reference(s)
T92UWJ Beta-2 adrenergic receptorADRB2 P07550
1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
4 Reference(s)
T56TXY Polyunsaturated fatty acid 5-lipoxygenaseALOX5 P09917
3 Reference(s)
T31U13 Cytochrome P450 2C19CYP2C19 P33261
1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
2 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
1 Reference(s)
T09BRP NAPKB_RS07820 NA
2 Reference(s)
T11ZYR Cytochrome P450 2D6CYP2D6 P10635
1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
2 Reference(s)
T54X6V Intermediate conductance calcium-activated potassium channel protein 4KCNN4 O15554
1 Reference(s)
T41B8C Peroxiredoxin-5, mitochondrialPRDX5 P30044
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
5 Reference(s)
T34Y8V Oxysterols receptor LXR-betaNR1H2 P55055
1 Reference(s)
T23K1O CalmodulinCALM3;CALML2;CAM3;CAMC;CAMIII P62158
1 Reference(s)
T32P8F Serine/threonine-protein phosphatase 5PPP5C P53041
1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
3 Reference(s)
T47HTN Prostaglandin E synthasePTGES O14684
1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
3 Reference(s)
T32YAJ G-protein coupled estrogen receptor 1GPER1 Q99527
1 Reference(s)
T11OU8 Progesterone receptorPGR P06401
1 Reference(s)
T94FQR Fibroblast growth factor 7FGF7 P21781
1 Reference(s)
T47OCS Fibroblast growth factor 10FGF10 O15520
1 Reference(s)
T22JG3 Fibroblast growth factor receptor 2FGFR2 P21802
2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
5 Reference(s)
T32IXS Integrin alpha-MITGAM P11215
1 Reference(s)
T04OY0 Granulocyte colony-stimulating factor receptorCSF3R Q99062
1 Reference(s)
T16A2X CatalaseCAT P04040
3 Reference(s)
T44LWL Transcription factor p65RELA Q04206
3 Reference(s)
T64X48 C-X-C chemokine receptor type 4CXCR4 P61073
1 Reference(s)
T45KYV Stromal cell-derived factor 1CXCL12 P48061
1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
2 Reference(s)
T46AQJ Glutathione S-transferase PGSTP1 P09211
1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
3 Reference(s)
T04WT7 FibronectinFN1 P02751
2 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
2 Reference(s)
T50FHQ TGF-beta receptor type-2TGFBR2 P37173
1 Reference(s)
T62P0D Collagenase 3MMP13 P45452
1 Reference(s)
T83QHM Beta-nerve growth factorNGF P01138
1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
1 Reference(s)
T16K98 Protein jagged-1JAG1 P78504
1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
1 Reference(s)
T13KGH TyrosinaseTYR P14679
1 Reference(s)
T67JR8 Heat shock factor protein 1HSF1 Q00613
1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
2 Reference(s)
T44S1A Apolipoprotein A-IAPOA1 P02647
1 Reference(s)
T58D39 OsteocalcinBGLAP P02818
1 Reference(s)
T29PSX Receptor of activated protein C kinase 1RACK1 P63244
1 Reference(s)
T24U57 E-selectinSELE P16581
2 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
2 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
2 Reference(s)
T64W2K Cyclin-dependent kinase inhibitor 1CDKN1A P38936
1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
3 Reference(s)
T37VLU Interferon gammaIFNG P01579
1 Reference(s)
T11AJ4 WW domain-containing oxidoreductaseWWOX Q9NZC7
1 Reference(s)
T77TY2 Protein disulfide-isomeraseP4HB P07237
1 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
2 Reference(s)
T89L4V InsulinINS P01308
1 Reference(s)
T35R2F PR domain zinc finger protein 2PRDM2 Q13029
1 Reference(s)
T61OY3 UDP-glucuronosyltransferase 1A1UGT1A1 P22309
1 Reference(s)
T57YL7 Sex hormone-binding globulinSHBG P04278
1 Reference(s)
T92Q77 Type I iodothyronine deiodinaseDIO1 P49895
1 Reference(s)
T99EYH Lipoprotein lipaseLPL P06858
1 Reference(s)
T99W15 Pancreatic triacylglycerol lipasePNLIP P16233
1 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
1 Reference(s)
T75H3W Cyclin-dependent kinase 2CDK2 P24941
1 Reference(s)
T86UXL Cyclin-A2CCNA2 P20248
1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
1 Reference(s)
T09GFP Maltase-glucoamylase, intestinal [Includes: MaltaseMGAM O43451
1 Reference(s)
T32UNL Lens fiber major intrinsic proteinMIP P30301
1 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
3 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
2 Reference(s)
T97KL5 Microsomal glutathione S-transferase 1MGST1 P10620
2 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
2 Reference(s)
T81BH5 Sulfotransferase 1A1SULT1A1 P50225
2 Reference(s)
T32SPJ Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPIK3CG P48736
1 Reference(s)
T28PHS Angiotensin-converting enzymeACE P12821
1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
1 Reference(s)
T31SX8 Bone morphogenetic protein 2BMP2 P12643
2 Reference(s)
T00CXT Prostaglandin G/H synthase 1PTGS1 P23219
1 Reference(s)
T99XQ3 DNA topoisomerase 1TOP1 P11387
1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
1 Reference(s)
T68BGR Glial fibrillary acidic proteinGFAP P14136
1 Reference(s)
T46YMA Ras-related C3 botulinum toxin substrate 1RAC1 P63000
1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
3 Reference(s)
T93R42 Dipeptidyl peptidase 1CTSC P53634
1 Reference(s)
T18CWB Transcriptional activator MybMYB P10242
1 Reference(s)
T02P7Q Dihydrofolate reductaseDHFR P00374
1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
1 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
1 Reference(s)
T61J7T Mothers against decapentaplegic homolog 2SMAD2 Q15796
1 Reference(s)
T61HH0 Prostate-specific antigenKLK3 P07288
1 Reference(s)
T68NCI Aldo-keto reductase family 1 member B1AKR1B1 P15121
1 Reference(s)
T29NEF ResistinRETN Q9HD89
1 Reference(s)
T45WII Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptideTGFB3 P10600
1 Reference(s)
T47X6Y Thyrotropin subunit betaTSHB P01222
1 Reference(s)
T21TC9 Kallikrein-10KLK10 O43240
1 Reference(s)
T28HOM LeptinLEP P41159
1 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
1 Reference(s)
T52FC6 Protein NDRG2NDRG2 Q9UN36
1 Reference(s)
T76EHP Glutathione S-transferase A1GSTA1 P08263
2 Reference(s)
T58N83 Serine/threonine-protein kinase STK11STK11 Q15831
1 Reference(s)
T69NNS PRKC apoptosis WT1 regulator proteinPAWR Q96IZ0
2 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
3 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
2 Reference(s)
T63VZZ Metastasis-suppressor KiSS-1KISS1 Q15726
2 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
2 Reference(s)
T00EP2 Tissue-type plasminogen activatorPLAT P00750
2 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
1 Reference(s)
T80MG0 Growth hormone secretagogue receptor type 1GHSR Q92847
2 Reference(s)
T98Z62 NAMIR144 NA
1 Reference(s)
T15N66 Myosin regulatory light polypeptide 9MYL9 P24844
1 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
2 Reference(s)
T82LND Myoblast determination protein 1MYOD1 P15172
1 Reference(s)
T95K0K Interferon alpha-1/13IFNA1; IFNA13 P01562
1 Reference(s)
T06JXV CD44 antigenCD44 P16070
1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
1 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
1 Reference(s)
T47WWK C-C chemokine receptor type 1CCR1 P32246
1 Reference(s)
T46PRA Excitatory amino acid transporter 3SLC1A1 P43005
1 Reference(s)
T11GHO Transforming protein RhoARHOA P61586
1 Reference(s)
T62G0S Cofilin-1CFL1 P23528
1 Reference(s)
T82N70 Interleukin-21IL21 Q9HBE4
1 Reference(s)
T43QZ3 SclerostinSOST Q9BQB4
1 Reference(s)
T77YFO Voltage-dependent L-type calcium channel subunit alpha-1CCACNA1C Q13936
1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
1 Reference(s)
T80R6A Insulin-like growth factor IIGF1 P05019
2 Reference(s)
T87TVN Toll-like receptor 5TLR5 O60602
1 Reference(s)
T38IRL Interferon-stimulated gene 20 kDa proteinISG20 Q96AZ6
1 Reference(s)
T10RBK Atrial natriuretic peptide receptor 2NPR2 P20594
1 Reference(s)
T28K6X Insulin receptor substrate 1IRS1 P35568
1 Reference(s)
T23RWU Type-1 angiotensin II receptorAGTR1 P30556
1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
2 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
1 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
1 Reference(s)
T42LAP NAMIR190B NA
1 Reference(s)
T50HUJ MerlinNF2 P35240
1 Reference(s)
T71HD9 NAMIR148A NA
1 Reference(s)
T52HO1 HLA class I histocompatibility antigen, alpha chain GHLA-G P17693
1 Reference(s)
T47T27 C-C motif chemokine 24CCL24 O00175
1 Reference(s)
T62L0I Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVFNPVF Q9HCQ7
1 Reference(s)
T51NKF Alpha-2-antiplasminSERPINF2 P08697
1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
1 Reference(s)
T06MXL NeprilysinMME P08473
1 Reference(s)
T94FK3 Progonadoliberin-2GNRH2 O43555
1 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
1 Reference(s)
T43BVC BasiginBSG P35613
1 Reference(s)
T87DEX Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseXDH P47989
1 Reference(s)
T76ZOF Apolipoprotein A-IVAPOA4 P06727
1 Reference(s)
T73PZA Vesicular inhibitory amino acid transporterSLC32A1 Q9H598
1 Reference(s)
T47G3X Glucocorticoid receptorNR3C1 P04150
1 Reference(s)
T73ND5 MyocilinMYOC Q99972
1 Reference(s)
T40MAR Cadherin-11CDH11 P55287
1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
1 Reference(s)
T04YQC Homeobox protein SIX6SIX6 O95475
1 Reference(s)
T06PVX E3 ubiquitin-protein ligase Mdm2MDM2 Q00987
1 Reference(s)
T56RMM DNADNMT3A Q9Y6K1
1 Reference(s)
T60WNX Vasopressin-neurophysin 2-copeptinAVP P01185
1 Reference(s)
T53FD0 Leptin receptorLEPR P48357
1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
1 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
1 Reference(s)
T91MLF Alpha-1-antitrypsinSERPINA1 P01009
1 Reference(s)
T46TBY Prostaglandin E2 receptor EP2 subtypePTGER2 P43116
1 Reference(s)
T68O49 Prostaglandin E2 receptor EP4 subtypePTGER4 P35408
1 Reference(s)
T35YGY Prostaglandin F2-alpha receptorPTGFR P43088
1 Reference(s)
T00H7Q Neutrophil cytosol factor 1NCF1 P14598
1 Reference(s)
T33OPP Interleukin-6IL6 P05231
2 Reference(s)
T27U96 Granulocyte-macrophage colony-stimulating factorCSF2 P04141
1 Reference(s)
T35QZO Cytochrome cCYCS P99999
1 Reference(s)
T08B2M M-phase inducer phosphatase 1CDC25A P30304
1 Reference(s)
T33UEM LactoperoxidaseLPO P22079
1 Reference(s)
T03TJ0 Interleukin-33IL33 O95760
1 Reference(s)
T40G6B Prostaglandin reductase 1PTGR1 Q14914
1 Reference(s)
T31VDH Myeloid differentiation primary response protein MyD88MYD88 Q99836
1 Reference(s)
T80U0C Glutathione synthetaseGSS P48637
1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
1 Reference(s)
T84VZG Ryanodine receptor 1RYR1 P21817
1 Reference(s)
T14ENF Microtubule-associated protein 2MAP2 P11137
1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
1 Reference(s)
T00OVG Semaphorin-3ASEMA3A Q14563
1 Reference(s)
T67HXL Glial cell line-derived neurotrophic factorGDNF P39905
1 Reference(s)
T50DXZ NAMIR126 NA
1 Reference(s)
T53KY7 Cystic fibrosis transmembrane conductance regulatorCFTR P13569
1 Reference(s)
T28RI5 Zinc finger E-box-binding homeobox 1ZEB1 P37275
1 Reference(s)
T75NEV Aquaporin-1AQP1 P29972
1 Reference(s)
T30AEN Aquaporin-5AQP5 P55064
1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
1 Reference(s)
T16UHV Nuclear factor of activated T-cells, cytoplasmic 1NFATC1 O95644
1 Reference(s)
T07NML P-selectinSELP P16109
1 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
1 Reference(s)
T69RXK Cytochrome P450 2C9CYP2C9 P11712
1 Reference(s)
T49XOZ Krueppel-like factor 7KLF7 O75840
1 Reference(s)

Related Compounds  (Total: 12)

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C0055
Name: Estradiol
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C1220
Name: Catechin
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C0333
Name: Protocatechuic Acid
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C0291
Name: Paraben
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C0090
Name: Gallic Acid