Target Description

Type Detail
Target ID T44S1A
Protein Name Apolipoprotein A-I
Uniprot ID P02647
Protein Name Alias Apo-AI;  ApoA-I;  Apolipoprotein A1
Gene ID 335
Gene Symbol APOA1
Gene Alias NA
TTD T56545: Clinical Trial target
Pfam PF01442
GO
0009986:cell surface

0045723:positive regulation of fatty acid biosynthetic process

0031072:heat shock protein binding

0044267:cellular protein metabolic process

0030301:cholesterol transport

0010903:negative regulation of very-low-density lipoprotein particle remodeling

0072562:blood microparticle

0007186:G protein-coupled receptor signaling pathway

0034364:high-density lipoprotein particle

0005102:signaling receptor binding

0005576:extracellular region

0030139:endocytic vesicle

0035025:positive regulation of Rho protein signal transduction

1990000:amyloid fibril formation

0008035:high-density lipoprotein particle binding

0008211:glucocorticoid metabolic process

0055091:phospholipid homeostasis

0060354:negative regulation of cell adhesion molecule production

0051006:positive regulation of lipoprotein lipase activity

0051345:positive regulation of hydrolase activity

1902995:positive regulation of phospholipid efflux

0042157:lipoprotein metabolic process

0046470:phosphatidylcholine metabolic process

0010804:negative regulation of tumor necrosis factor-mediated signaling pathway

0034378:chylomicron assembly

0001932:regulation of protein phosphorylation

0034375:high-density lipoprotein particle remodeling

0007229:integrin-mediated signaling pathway

0034372:very-low-density lipoprotein particle remodeling

0034384:high-density lipoprotein particle clearance

0002576:platelet degranulation

0005543:phospholipid binding

0060192:negative regulation of lipase activity

0042802:identical protein binding

0033700:phospholipid efflux

0050821:protein stabilization

0019899:enzyme binding

0043691:reverse cholesterol transport

1900026:positive regulation of substrate adhesion-dependent cell spreading

0001523:retinoid metabolic process

0018206:peptidyl-methionine modification

0060228:phosphatidylcholine-sterol O-acyltransferase activator activity

0042158:lipoprotein biosynthetic process

0034365:discoidal high-density lipoprotein particle

0070653:high-density lipoprotein particle receptor binding

0032489:regulation of Cdc42 protein signal transduction

0001540:amyloid-beta binding

0034115:negative regulation of heterotypic cell-cell adhesion

0034191:apolipoprotein A-I receptor binding

0045499:chemorepellent activity

0042493:response to drug

0006695:cholesterol biosynthetic process

0120020:cholesterol transfer activity

0043627:response to estrogen

0046889:positive regulation of lipid biosynthetic process

0001935:endothelial cell proliferation

0014012:peripheral nervous system axon regeneration

0055102:lipase inhibitor activity

0034362:low-density lipoprotein particle

0051496:positive regulation of stress fiber assembly

0034380:high-density lipoprotein particle assembly

0006898:receptor-mediated endocytosis

0006656:phosphatidylcholine biosynthetic process

0005886:plasma membrane

0071682:endocytic vesicle lumen

0070508:cholesterol import

0008203:cholesterol metabolic process

0034371:chylomicron remodeling

0043687:post-translational protein modification

0010875:positive regulation of cholesterol efflux

0034363:intermediate-density lipoprotein particle

0010873:positive regulation of cholesterol esterification

0018158:protein oxidation

0006869:lipid transport

0015485:cholesterol binding

0050728:negative regulation of inflammatory response

0005634:nucleus

0019222:regulation of metabolic process

0005769:early endosome

0050766:positive regulation of phagocytosis

0005788:endoplasmic reticulum lumen

0050919:negative chemotaxis

0010898:positive regulation of triglyceride catabolic process

0042627:chylomicron

0070062:extracellular exosome

0005615:extracellular space

0042632:cholesterol homeostasis

0043534:blood vessel endothelial cell migration

0033344:cholesterol efflux

0060761:negative regulation of response to cytokine stimulus

0031210:phosphatidylcholine binding

0007584:response to nutrient

0034190:apolipoprotein receptor binding

0005829:cytosol

0062023:collagen-containing extracellular matrix

0070328:triglyceride homeostasis

0051180:vitamin transport

0002719:negative regulation of cytokine production involved in immune response

0030300:regulation of intestinal cholesterol absorption

0034774:secretory granule lumen

0034366:spherical high-density lipoprotein particle

0031100:animal organ regeneration

0034361:very-low-density lipoprotein particle

0030325:adrenal gland development

0019915:lipid storage

0032691:negative regulation of interleukin-1 beta production

0031410:cytoplasmic vesicle

1903561:extracellular vesicle

PDB 2MSD ; 3K2S ; 3R2P ; 7KJR ; 6W4E ; 6CCH ; 2MSE ; 1ODQ ; 1AV1 ; 6PTW ; 6CC9 ; 6CM1 ; 6CLZ ; 2MSC ; 1ODP ; 4V6M ; 1GW4 ; 6CCX ; 2N5E ; 1GW3 ; 6W4F ; 1ODR ; 6PTS
Drugbank DB09130 ; DB14533 ; DB01593 ; DB14548 ; DB14487
KEGG hsa:335

Related Compounds  (Total: 6)

Go to browser
C0055
Name: Estradiol
Go to browser
C0101
Name: Genistein
Go to browser
C0383
Name: Salicylic Acid
Go to browser
C0554
Name: Cholesterol
Go to browser
C0569
Name: Sucrose


Related Herbs  (Total: 145)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0713 Che Qian Cao车前草 all-grass of rippleseed plantainPlantago depressa
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0802 Zhi Geng枳梗 NACitrus aurantium
H0832 Zhu Sha Gen朱砂根 Coral ardisiaArdisia crenata
H1044 Feng Wei Cao凤尾草 Chinese brakePteris multifida
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0357 Ren Shen人参 GinsengPanax ginseng
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0312 Po Gu Zhi破故纸 fruit of malaytea scurfpeaFructus psoraleae corylifoliae
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H1038 Feng Fang蜂房 HoneycombNidus vespae
H0026 Jiang Soybean pasteGlycine max
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0718 Yang Jiao Qi羊角七 NABletilla striata
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0631 Xi Yang Shen西洋参 American ginsengPanax quinquefolium
H0537 Tian Dong天冬 Cochinchinese asparagus rootAsparagus cochinchinensis
H1238 Huang Jing黄精 Siberian solomonsealPolygonatum sibiricum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1225 Huai Mi槐米 NASophora japonica
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0972 Di Huang地黄 RehmanniaeRehmannia glutinosa
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H1227 Huai Zhi槐枝 NASophora japonica
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0265 Mu Da Qing Ye木大青叶 Indigo-coloured woad leaf equivalentIsatis indigotica
H1113 Guan Bai Fu关白附 Korean monk's hoodAconitum coreanum
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0445 Sheng Guan Bai Fu生关白附 NAAconitum coreanum
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0331 Qiang Huo羌活 Incised notopterygiumNotopterygium incisum
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H0131 Ban Lan板蓝 Indigowoad rootIsatis indigotica
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H1239 Huang Jing Gan Jin Gao黄精干浸膏 NAPolygonatum sibiricum
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0468 Shi Wei石韦 Japanese felt fern frondPyrrosia lingua
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H1030 Fang Feng防风 Divaricate saposhnikoviaSaposhnikovia divaricata
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0077 Jiu EthanolVinum
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1007 Dou You豆油 Soybean oilGlycine max
H0137 Ban Lan Gen板蓝根 Indigowoad rootIsatis indigotica
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0715 Che Qian Zi车前子 seed of asiatic pantainPlantago asiatica
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0908 Ci Wu Jia刺五加 Manypr ickle acanthopana xEleutherococcus senticosus
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H1079 Gan Di Huang干地黄 Adhesive rehmannia dried rootRehmannia glutinosa
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0838 Zhu Zi Shen珠子参 Largeleaf japanese ginseng rhizomeRhizoma panacis majoris
H0971 Bai Bian Dou白扁豆 White hyacinth beanLablab purpureus
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1156 Ai Di Huang矮地黄 RehmanniaeRehmannia glutinosa
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0973 Di Huang Tan地黄炭 RehmanniaeRehmannia glutinosa
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0937 Da Qing Ye大青叶 Indigo-coloured woad leafIsatis indigotica
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0168 Long Yan Rou龙眼肉 Longan arilArillus longan
H0408 Bing Lang槟榔 BetenutpalmAreca catechu
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0447 Sheng Ma升麻 BugbaneCimicifuga foetida
H0263 Mu Ban Lan Gen木板蓝根 Indigowoad rootIsatis indigotica
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0542 Tian Ma天麻 Tall gastrodiaGastrodia elata
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0803 Zhi Huang Jing制黄精 Prepared rhizome of fragrant solomonsealPolygonatum sibiricum
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H1200 Bai Mao Gen白茅根 Lalang grass rhizomeImperata cylindrica
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0523 Cang Er Zi苍耳子 fruit of siberian cockleblurFructus xanthii sibirici
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0564 Tu Bei Mu土贝母 Paniculate bolbostemmaRhizoma bolbostemmae
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0215 Mai Ya麦芽 Barley germinating fruitHordeum vulgare
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H1118 Bai Ji白芨 Common bletillaBletilla striata
H1056 Fu Pen Zi覆盆子 Red-and-Yellow garden raspberryRubus idaeus
H0081 Jiu Huang Jing酒黄精 Siberian solomonsealPolygonatum sibiricum
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0416 Shan Shen山参 NAPanax ginseng
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0473 Shu Di Huang熟地黄 Adhesive rehmannia cocked rootRehmannia glutinosa