Herb Description
| Herb ID: H0473 | Chinese Character: 熟地黄 |
| English Name: Adhesive rehmannia cocked root | Latin Name: Rehmannia glutinosa |
| Chinese Pin Yin : Shu Di Huang | TCM-ID: TCMH1966 |
| Therapeutic Function in Chinese : 补虚 | Therapeutic Function in English: For tonifying weakness |
| Herb Function: Nourish n and replenish blood, reinforce the essence of life and marrow | |
Related Targets (Total: 178)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
3 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
5 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
3 Reference(s) |
| T77PFO | Histone deacetylase 6 | HDAC6 |
Q9UBN7 |
1 Reference(s) |
| T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
| T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
5 Reference(s) |
| T37G49 | Platelet-activating factor acetylhydrolase | PLA2G7 |
Q13093 |
1 Reference(s) |
| T86J48 | Sodium/glucose cotransporter 1 | SLC5A1 |
P13866 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
1 Reference(s) |
| T00T99 | S-adenosylhomocysteine hydrolase-like protein 1 | AHCYL1 |
O43865 |
1 Reference(s) |
| T21CMG | Hepcidin | HAMP |
P81172 |
2 Reference(s) |
| T20RA0 | Adenosine deaminase | ADA |
P00813 |
1 Reference(s) |
| T36HAE | D-amino-acid oxidase | DAO |
P14920 |
1 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
| T89GFN | Macrophage migration inhibitory factor | MIF |
P14174 |
1 Reference(s) |
| T16X77 | Solute carrier family 15 member 1 | SLC15A1 |
P46059 |
1 Reference(s) |
| T24F1A | Pyruvate kinase PKLR | PKLR |
P30613 |
1 Reference(s) |
| T32JN2 | Beta-glucuronidase | GUSB |
P08236 |
1 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
2 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
2 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
5 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
5 Reference(s) |
| T06VX0 | MAP/microtubule affinity-regulating kinase 4 | MARK4 |
Q96L34 |
3 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
1 Reference(s) |
| T20IHC | Diacylglycerol O-acyltransferase 1 | DGAT1 |
O75907 |
1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
2 Reference(s) |
| T16UZ4 | Dipeptidyl peptidase 4 | DPP4 |
P27487 |
1 Reference(s) |
| T70KPE | Transient receptor potential cation channel subfamily V member 3 | TRPV3 |
Q8NET8 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
2 Reference(s) |
| T98QOA | DNA-dependent protein kinase catalytic subunit | PRKDC |
P78527 |
2 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
4 Reference(s) |
| T31EJG | Apoptotic protease-activating factor 1 | APAF1 |
O14727 |
1 Reference(s) |
| T09INZ | Transient receptor potential cation channel subfamily A member 1 | TRPA1 |
O75762 |
1 Reference(s) |
| T35QZO | Cytochrome c | CYCS |
P99999 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
2 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
3 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
2 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
5 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
3 Reference(s) |
| T70U24 | Sigma non-opioid intracellular receptor 1 | SIGMAR1 |
Q99720 |
1 Reference(s) |
| T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
2 Reference(s) |
| T80OPZ | NADPH oxidase 4 | NOX4 |
Q9NPH5 |
1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
2 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
1 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
2 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
2 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
4 Reference(s) |
| T74WWP | Peroxisome proliferator-activated receptor delta | PPARD |
Q03181 |
1 Reference(s) |
| T14JSX | Plasminogen | PLG |
P00747 |
2 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
| T67LRH | RNA-binding protein Musashi homolog 1 | MSI1 |
O43347 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
4 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
1 Reference(s) |
| T13WH4 | Interferon-induced, double-stranded RNA-activated protein kinase | EIF2AK2 |
P19525 |
8 Reference(s) |
| T68HNO | Glutathione S-transferase omega-1 | GSTO1 |
P78417 |
1 Reference(s) |
| T61LV9 | Free fatty acid receptor 3 | FFAR3 |
O14843 |
1 Reference(s) |
| T76MVQ | Free fatty acid receptor 4 | FFAR4 |
Q5NUL3 |
1 Reference(s) |
| T08U92 | Mitochondrial brown fat uncoupling protein 1 | UCP1 |
P25874 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
2 Reference(s) |
| T64V6C | Glutamate decarboxylase 1 | GAD1 |
Q99259 |
1 Reference(s) |
| T83RKS | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | MGAT1 |
P26572 |
2 Reference(s) |
| T73PZA | Vesicular inhibitory amino acid transporter | SLC32A1 |
Q9H598 |
1 Reference(s) |
| T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
4 Reference(s) |
| T35WLZ | Sodium- and chloride-dependent GABA transporter 3 | SLC6A11 |
P48066 |
2 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
| T41Z1X | Gamma-aminobutyric acid receptor-associated protein | GABARAP |
O95166 |
1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
2 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
2 Reference(s) |
| T76TED | Pro-opiomelanocortin | POMC |
P01189 |
1 Reference(s) |
| T37JN5 | Neutrophil gelatinase-associated lipocalin | LCN2 |
P80188 |
1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
1 Reference(s) |
| T09GFP | Maltase-glucoamylase, intestinal [Includes: Maltase | MGAM |
O43451 |
1 Reference(s) |
| T32UNL | Lens fiber major intrinsic protein | MIP |
P30301 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
2 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
2 Reference(s) |
| T47DIY | ATP-dependent 6-phosphofructokinase, muscle type | PFKM |
P08237 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
2 Reference(s) |
| T48J1U | Aldo-keto reductase family 1 member C1 | AKR1C1 |
Q04828 |
1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
| T92HNO | High mobility group protein B1 | HMGB1 |
P09429 |
1 Reference(s) |
| T23Z2G | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH |
P04406 |
1 Reference(s) |
| T97F4Y | High mobility group protein B3 | HMGB3 |
O15347 |
1 Reference(s) |
| T41S16 | Atrial natriuretic peptide receptor 3 | NPR3 |
P17342 |
1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
2 Reference(s) |
| T97KL5 | Microsomal glutathione S-transferase 1 | MGST1 |
P10620 |
2 Reference(s) |
| T81BH5 | Sulfotransferase 1A1 | SULT1A1 |
P50225 |
2 Reference(s) |
| T32SPJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | PIK3CG |
P48736 |
1 Reference(s) |
| T05V67 | Toll-like receptor 8 | TLR8 |
Q9NR97 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
6 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
2 Reference(s) |
| T39YFG | Trypsin-1 | PRSS1 |
P07477 |
1 Reference(s) |
| T54WR0 | Fatty acid-binding protein 5 | FABP5 |
Q01469 |
1 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
1 Reference(s) |
| T07S0E | BDNF/NT-3 growth factors receptor | NTRK2 |
Q16620 |
1 Reference(s) |
| T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
| T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
2 Reference(s) |
| T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
2 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
| T23YZF | Peptidyl-glycine alpha-amidating monooxygenase | PAM |
P19021 |
1 Reference(s) |
| T77FOL | Neuromodulin | GAP43 |
P17677 |
1 Reference(s) |
| T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
| T02DEN | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide | GCG |
P01275 |
1 Reference(s) |
| T48UT8 | Cholesteryl ester transfer protein | CETP |
P11597 |
1 Reference(s) |
| T32HPO | Aspartyl aminopeptidase | DNPEP |
Q9ULA0 |
1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T02YLA | Alpha-lactalbumin | LALBA |
P00709 |
1 Reference(s) |
| T82S6C | Hexokinase-4 | GCK |
P35557 |
1 Reference(s) |
| T18CPB | Choline O-acetyltransferase | CHAT |
P28329 |
1 Reference(s) |
| T02HSM | Neuroglobin | NGB |
Q9NPG2 |
1 Reference(s) |
| T04V7K | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | ENPP7 |
Q6UWV6 |
1 Reference(s) |
| T51U9M | Carnitine O-palmitoyltransferase 1, muscle isoform | CPT1B |
Q92523 |
1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
2 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
1 Reference(s) |
| T51EKP | Apolipoprotein M | APOM |
O95445 |
1 Reference(s) |
| T07VV7 | Guanylin | GUCA2A |
Q02747 |
1 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
| T80WPU | Protein ABHD15 | ABHD15 |
Q6UXT9 |
1 Reference(s) |
| T56OUM | 14-3-3 protein zeta/delta | YWHAZ |
P63104 |
1 Reference(s) |
| T24YWQ | Insulin-degrading enzyme | IDE |
P14735 |
1 Reference(s) |
| T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
1 Reference(s) |
| T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
2 Reference(s) |
| T29TYJ | Inositol-3-phosphate synthase 1 | ISYNA1 |
Q9NPH2 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
2 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
2 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
2 Reference(s) |
| T98DNG | Natriuretic peptides A | NPPA |
P01160 |
1 Reference(s) |
| T78ILO | Stearoyl-CoA desaturase | SCD |
O00767 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T68IZC | Natriuretic peptides B | NPPB |
P16860 |
1 Reference(s) |
| T02H9U | Nuclear factor of activated T-cells, cytoplasmic 4 | NFATC4 |
Q14934 |
1 Reference(s) |
| T41BYM | Fibroblast growth factor 23 | FGF23 |
Q9GZV9 |
1 Reference(s) |
| T85CC2 | Peptidyl-prolyl cis-trans isomerase D | PPID |
Q08752 |
1 Reference(s) |
| T02FO3 | Golgi-associated plant pathogenesis-related protein 1 | GLIPR2 |
Q9H4G4 |
1 Reference(s) |
| T10I26 | Interferon beta | IFNB1 |
P01574 |
1 Reference(s) |
| T44S1A | Apolipoprotein A-I | APOA1 |
P02647 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T20PAH | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | FTH1 |
P02794 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
1 Reference(s) |
| T46K2X | Heat shock 70 kDa protein 4 | HSPA4 |
P34932 |
1 Reference(s) |
| T86DIE | Folate binding protein | NA |
Q6LDL1 |
1 Reference(s) |
| T08B2M | M-phase inducer phosphatase 1 | CDC25A |
P30304 |
1 Reference(s) |
| T33UEM | Lactoperoxidase | LPO |
P22079 |
1 Reference(s) |
| T03TJ0 | Interleukin-33 | IL33 |
O95760 |
1 Reference(s) |
| T40G6B | Prostaglandin reductase 1 | PTGR1 |
Q14914 |
1 Reference(s) |
| T31VDH | Myeloid differentiation primary response protein MyD88 | MYD88 |
Q99836 |
1 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
1 Reference(s) |
| T50GQE | Interleukin-13 | IL13 |
P35225 |
1 Reference(s) |
| T67RBZ | Mitochondrial uncoupling protein 2 | UCP2 |
P55851 |
1 Reference(s) |
| T67HYX | Mitochondrial uncoupling protein 3 | UCP3 |
P55916 |
1 Reference(s) |
| T19EKF | Cholecystokinin | CCK |
P06307 |
1 Reference(s) |
| T23APZ | Retinol-binding protein 2 | RBP2 |
P50120 |
1 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
1 Reference(s) |
| T03NWF | Sterol O-acyltransferase 1 | SOAT1 |
P35610 |
1 Reference(s) |
| T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
1 Reference(s) |
| T53SLQ | Aquaporin-9 | AQP9 |
O43315 |
1 Reference(s) |
| T75EH8 | Glucagon-like peptide 1 receptor | GLP1R |
P43220 |
1 Reference(s) |
| T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
1 Reference(s) |
| T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
2 Reference(s) |
| T18CUI | Neuron-specific calcium-binding protein hippocalcin | HPCA |
P84074 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
1 Reference(s) |
| T08SJX | Astrocytic phosphoprotein PEA-15 | PEA15 |
Q15121 |
1 Reference(s) |
| T38OQ4 | Peroxiredoxin-2 | PRDX2 |
P32119 |
1 Reference(s) |
| T38J3Y | Gamma-enolase | ENO2 |
P09104 |
1 Reference(s) |
Related Compounds (Total: 26)
C0094
Name: Gamma-Aminobutyric Acid
C1243
Name: Cinnamic Acid
C0416
Name: Stearic Acid
C0285
Name: Palmitic Acid
C0420
Name: Succinic Acid
key description of the interaction between compound and target