Target Description

Type Detail
Target ID T98QOA
Protein Name DNA-dependent protein kinase catalytic subunit
Uniprot ID P78527
Protein Name Alias DNA-PK catalytic subunit;  DNA-PKcs;  EC 2.7.11.1;  DNPK1;  p460
Gene ID 5591
Gene Symbol PRKDC
Gene Alias HYRC;  HYRC1
TTD T81735: Clinical Trial target
Pfam PF02260 ; PF02259 ; PF08163 ; PF00454
GO
0005730:nucleolus

0001933:negative regulation of protein phosphorylation

0035234:ectopic germ cell programmed cell death

0045727:positive regulation of translation

0000723:telomere maintenance

0001756:somitogenesis

0043065:positive regulation of apoptotic process

0004672:protein kinase activity

0005634:nucleus

0002638:negative regulation of immunoglobulin production

0031648:protein destabilization

0014823:response to activity

0003723:RNA binding

0019899:enzyme binding

0033153:T cell receptor V(D)J recombination

0050678:regulation of epithelial cell proliferation

0002326:B cell lineage commitment

0097681:double-strand break repair via alternative nonhomologous end joining

0032869:cellular response to insulin stimulus

0072431:signal transduction involved in mitotic G1 DNA damage checkpoint

0018107:peptidyl-threonine phosphorylation

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0033152:immunoglobulin V(D)J recombination

0005524:ATP binding

0045087:innate immune response

0005667:transcription regulator complex

0003690:double-stranded DNA binding

0010332:response to gamma radiation

0032991:protein-containing complex

0016567:protein ubiquitination

0034511:U3 snoRNA binding

0048511:rhythmic process

1902036:regulation of hematopoietic stem cell differentiation

0004674:protein serine/threonine kinase activity

1905221:positive regulation of platelet formation

0002328:pro-B cell differentiation

0016020:membrane

0019904:protein domain specific binding

2000773:negative regulation of cellular senescence

0005958:DNA-dependent protein kinase-DNA ligase 4 complex

0106311:protein threonine kinase activity

0016233:telomere capping

0008134:transcription factor binding

0048538:thymus development

0006468:protein phosphorylation

0006974:cellular response to DNA damage stimulus

0033077:T cell differentiation in thymus

0004677:DNA-dependent protein kinase activity

0045944:positive regulation of transcription by RNA polymerase II

0006303:double-strand break repair via nonhomologous end joining

0032993:protein-DNA complex

0000460:maturation of 5.8S rRNA

0006302:double-strand break repair

0045648:positive regulation of erythrocyte differentiation

0005654:nucleoplasm

0000781:chromosome, telomeric region

0032040:small-subunit processome

0048146:positive regulation of fibroblast proliferation

0002218:activation of innate immune response

0106310:protein serine kinase activity

0005829:cytosol

0043066:negative regulation of apoptotic process

2001034:positive regulation of double-strand break repair via nonhomologous end joining

0042752:regulation of circadian rhythm

0045621:positive regulation of lymphocyte differentiation

0002360:T cell lineage commitment

0007420:brain development

0034462:small-subunit processome assembly

0048660:regulation of smooth muscle cell proliferation

0007507:heart development

0070419:nonhomologous end joining complex

2001229:negative regulation of response to gamma radiation

0018105:peptidyl-serine phosphorylation

0048536:spleen development

0048639:positive regulation of developmental growth

0032481:positive regulation of type I interferon production

0006464:cellular protein modification process

PDB 7K1K ; 6ZHA ; 6ZH4 ; 6ZH6 ; 6ZHE ; 7K10 ; 7K1B ; 5Y3R ; 6ZH8 ; 7K1J ; 7K19 ; 6ZFP ; 6ZH2 ; 5W1R ; 7K1N ; 7K11 ; 5LUQ
Drugbank DB05210 ; DB00201
KEGG hsa:5591

Related Compounds  (Total: 5)

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C0101
Name: Genistein
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C0443
Name: Theophylline
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C0479
Name: Vanillin
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C1113
Name: heparin
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C1193
Name: Bisphenol A


Related Herbs  (Total: 125)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0763 Yu Mi Xu玉米须 Maize styleZea mays
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H1227 Huai Zhi槐枝 NASophora japonica
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0524 Tan Xiang檀香 SandalwoodSantalum album
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1156 Ai Di Huang矮地黄 RehmanniaeRehmannia glutinosa
H1052 Fu Fang Teng扶芳藤 Forture euonymusEuonymus fortunei
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1013 Du Jiao Qiu独脚球 Flat-leaved vanillaVanilla planifolia
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0841 Chou Wu Tong臭梧桐 Harlequin glorybowerClerodendrum trichotomum
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0672 Xin Jiang Gao Ben新疆藁本 Vaginate hemlockparsleyConioselinum vaginatum
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H1056 Fu Pen Zi覆盆子 Red-and-Yellow garden raspberryRubus idaeus
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0892 Chuan Xiong川芎 cnidium officinaleCnidium officinale
H0357 Ren Shen人参 GinsengPanax ginseng
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0566 Cao Cong Rong草苁蓉 Russian boschniakiaBoschniakia rossica
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1007 Dou You豆油 Soybean oilGlycine max
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0542 Tian Ma天麻 Tall gastrodiaGastrodia elata
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0973 Di Huang Tan地黄炭 RehmanniaeRehmannia glutinosa
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H1079 Gan Di Huang干地黄 Adhesive rehmannia dried rootRehmannia glutinosa
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0578 Tu San Qi土三七 Chrusanthemum-like groundselGynura segetum
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0893 Chuan Xiong Jin Gao川芎浸膏 cnidium officinaleCnidium officinale
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0747 An Xi Xiang安息香 Sumatra snowbelStyrax benzoin
H0416 Shan Shen山参 NAPanax ginseng
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0026 Jiang Soybean pasteGlycine max
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0642 Xiang Jia Pi香加皮 Chinese silkvine root-barkPeriploca sepium
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H1004 Bai Cha白茶 White teaCamellia sinensis
H0076 Jing Tian San Qi景天三七 Chrusanthemum-like groundselGynura segetum
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0526 Tang Gu Te Wu Tou唐古特乌头 NAAconitum tanguticum
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H1229 Bai Mu Xiang白木香 Chinese eaglewoodAquilaria sinensis
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0902 Chun Pi椿皮 Ailanthus bark, tree of heaven barkAilanthi cortex
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0510 Su He Xiang苏合香 Oriental sweetgum resinLiquidambar orientalis
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0755 Ying Shan Hong映山红 Korean rhododendronRhododendron mucronulatum
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0473 Shu Di Huang熟地黄 Adhesive rehmannia cocked rootRehmannia glutinosa
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0695 Ya Dan Zi鸦胆子 Java bruceaBrucea javanica
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H1225 Huai Mi槐米 NASophora japonica
H0688 Xuan Shen玄参 Ningpo figwortScrophularia ningpoensis
H0846 Chou Wu Tong Ye臭梧桐叶 Harlequin glorybowerClerodendrum trichotomum
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0204 Ma Ren麻仁 NACannabis sativa
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0768 Yuan Shen元参 Figwort rootScrophularia ningpoensis
H0567 Tu Da Huang土大黄 NARumex obtusifolius
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H1110 Gua Lou Zi瓜蒌子 mongolian snakegourd seedTrichosanthes kirilowii maxim
H0972 Di Huang地黄 RehmanniaeRehmannia glutinosa
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis