Herb Description
| Herb ID: H0768 | Chinese Character: 元参 |
| English Name: Figwort root | Latin Name: Scrophularia ningpoensis |
| Chinese Pin Yin : Yuan Shen | TCM-ID: TCMH2553 |
| Therapeutic Function in Chinese : 清热 | Therapeutic Function in English: Heat clearence |
| Herb Function: Reduce heat from blood, nourish yin, quench fire, and counteract toxicity | |
Related Targets (Total: 115)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
3 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
2 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
4 Reference(s) |
| T36HAE | D-amino-acid oxidase | DAO |
P14920 |
1 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
| T89GFN | Macrophage migration inhibitory factor | MIF |
P14174 |
1 Reference(s) |
| T16X77 | Solute carrier family 15 member 1 | SLC15A1 |
P46059 |
1 Reference(s) |
| T70KPE | Transient receptor potential cation channel subfamily V member 3 | TRPV3 |
Q8NET8 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
1 Reference(s) |
| T06VX0 | MAP/microtubule affinity-regulating kinase 4 | MARK4 |
Q96L34 |
2 Reference(s) |
| T98QOA | DNA-dependent protein kinase catalytic subunit | PRKDC |
P78527 |
2 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
5 Reference(s) |
| T31EJG | Apoptotic protease-activating factor 1 | APAF1 |
O14727 |
1 Reference(s) |
| T09INZ | Transient receptor potential cation channel subfamily A member 1 | TRPA1 |
O75762 |
1 Reference(s) |
| T35QZO | Cytochrome c | CYCS |
P99999 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
3 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
2 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
8 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
2 Reference(s) |
| T05PKX | Steroid 17-alpha-hydroxylase/17,20 lyase | CYP17A1 |
P05093 |
1 Reference(s) |
| T85S9Z | Cholesterol side-chain cleavage enzyme, mitochondrial | CYP11A1 |
P05108 |
1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
2 Reference(s) |
| T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
3 Reference(s) |
| T50SJ8 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | PRKAA2 |
P54646 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
2 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
1 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
2 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T13WH4 | Interferon-induced, double-stranded RNA-activated protein kinase | EIF2AK2 |
P19525 |
8 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
2 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
3 Reference(s) |
| T74WWP | Peroxisome proliferator-activated receptor delta | PPARD |
Q03181 |
1 Reference(s) |
| T14JSX | Plasminogen | PLG |
P00747 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
| T67LRH | RNA-binding protein Musashi homolog 1 | MSI1 |
O43347 |
1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
1 Reference(s) |
| T41INV | Nuclear receptor subfamily 1 group I member 3 | NR1I3 |
Q14994 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
1 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
3 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
4 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
| T80XW6 | Scavenger receptor class B member 1 | SCARB1 |
Q8WTV0 |
1 Reference(s) |
| T02DEN | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide | GCG |
P01275 |
2 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T39YFG | Trypsin-1 | PRSS1 |
P07477 |
1 Reference(s) |
| T54WR0 | Fatty acid-binding protein 5 | FABP5 |
Q01469 |
1 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
| T07S0E | BDNF/NT-3 growth factors receptor | NTRK2 |
Q16620 |
1 Reference(s) |
| T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
| T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
1 Reference(s) |
| T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
2 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
2 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
| T23YZF | Peptidyl-glycine alpha-amidating monooxygenase | PAM |
P19021 |
1 Reference(s) |
| T77FOL | Neuromodulin | GAP43 |
P17677 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
2 Reference(s) |
| T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
| T48UT8 | Cholesteryl ester transfer protein | CETP |
P11597 |
1 Reference(s) |
| T32HPO | Aspartyl aminopeptidase | DNPEP |
Q9ULA0 |
1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T02YLA | Alpha-lactalbumin | LALBA |
P00709 |
1 Reference(s) |
| T02HSM | Neuroglobin | NGB |
Q9NPG2 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
2 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
2 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
4 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
1 Reference(s) |
| T42HHN | Follicle-stimulating hormone receptor | FSHR |
P23945 |
1 Reference(s) |
| T90ADC | BH3-interacting domain death agonist | BID |
P55957 |
1 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
1 Reference(s) |
| T09KPZ | Vimentin | VIM |
P08670 |
1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
1 Reference(s) |
| T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
1 Reference(s) |
| T14ENF | Microtubule-associated protein 2 | MAP2 |
P11137 |
1 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
1 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
2 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
1 Reference(s) |
| T18CUI | Neuron-specific calcium-binding protein hippocalcin | HPCA |
P84074 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
1 Reference(s) |
| T08SJX | Astrocytic phosphoprotein PEA-15 | PEA15 |
Q15121 |
1 Reference(s) |
| T38OQ4 | Peroxiredoxin-2 | PRDX2 |
P32119 |
1 Reference(s) |
| T38J3Y | Gamma-enolase | ENO2 |
P09104 |
1 Reference(s) |
| T82I7J | C-C motif chemokine 16 | CCL16 |
O15467 |
1 Reference(s) |
| T70HC9 | Hepatocyte nuclear factor 1-alpha | HNF1A |
P20823 |
1 Reference(s) |
| T49J7I | Hepatocyte nuclear factor 4-alpha | HNF4A |
P41235 |
1 Reference(s) |
| T67RBZ | Mitochondrial uncoupling protein 2 | UCP2 |
P55851 |
2 Reference(s) |
| T67HYX | Mitochondrial uncoupling protein 3 | UCP3 |
P55916 |
1 Reference(s) |
| T19EKF | Cholecystokinin | CCK |
P06307 |
1 Reference(s) |
| T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
1 Reference(s) |
| T23APZ | Retinol-binding protein 2 | RBP2 |
P50120 |
1 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
1 Reference(s) |
| T03NWF | Sterol O-acyltransferase 1 | SOAT1 |
P35610 |
1 Reference(s) |
| T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
1 Reference(s) |
| T53SLQ | Aquaporin-9 | AQP9 |
O43315 |
1 Reference(s) |
| T75EH8 | Glucagon-like peptide 1 receptor | GLP1R |
P43220 |
1 Reference(s) |
| T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
1 Reference(s) |
| T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
1 Reference(s) |
Related Compounds (Total: 14)
C1243
Name: Cinnamic Acid
C1030
Name: Aucubin
C1166
Name: Benzoic Acid
C0479
Name: Vanillin
C0014
Name: Dibutyl Phthalate
key description of the interaction between compound and target