Target Description

Type Detail
Target ID T70HC9
Protein Name Hepatocyte nuclear factor 1-alpha
Uniprot ID P20823
Protein Name Alias HNF-1-alpha;  HNF-1A;  Liver-specific transcription factor LF-B1;  LFB1;  Transcription factor 1;  TCF-1
Gene ID 6927
Gene Symbol HNF1A
Gene Alias TCF1
TTD T03556: Clinical Trial target
Pfam PF04813 ; PF04812 ; PF04814
GO
0005634:nucleus

0046983:protein dimerization activity

0003700:DNA-binding transcription factor activity

0042593:glucose homeostasis

0032991:protein-containing complex

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0042803:protein homodimerization activity

0000976:transcription regulatory region sequence-specific DNA binding

0046982:protein heterodimerization activity

0030073:insulin secretion

0045893:positive regulation of transcription, DNA-templated

0035623:renal glucose absorption

0045944:positive regulation of transcription by RNA polymerase II

0046323:glucose import

0006357:regulation of transcription by RNA polymerase II

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0031016:pancreas development

0001889:liver development

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0003677:DNA binding

0005737:cytoplasm

0000785:chromatin

0060261:positive regulation of transcription initiation from RNA polymerase II promoter

PDB 1IC8 ; 2GYP
Drugbank DB04419
KEGG hsa:6927

Related Compounds  (Total: 2)

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C0190
Name: Linolenic Acid
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C1228
Name: Chenodiol


Related Herbs  (Total: 132)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0743 Yi Zhi Ren益智仁 Sharpleaf galangalAlpinia oxyphylla
H0713 Che Qian Cao车前草 all-grass of rippleseed plantainPlantago depressa
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0332 Qiao Mai荞麦 Common buckwheatFagopyrum esculentum
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0357 Ren Shen人参 GinsengPanax ginseng
H0238 Mei Hua梅花 Plum flowerFlos mume
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0584 Tu Wu Jia土五加 NAAcanthopanax gracilistylus
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0597 Wu Jia Pi五加皮 Slenderstyle acanthopanax root-barkAcanthopanax gracilistylus
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0255 Mao Zhao Cao猫爪草 Root of catclaw buttercupRanunculus ternatus
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0558 Ting Li Zi葶苈子 Descurainia sophiaLepidium apetalum
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1225 Huai Mi槐米 NASophora japonica
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H1227 Huai Zhi槐枝 NASophora japonica
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0969 Di Fu Zi地肤子 fruit of belvedereFructus kochiae
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H0850 Zi Su Ye紫苏叶 Common perilla leafPerilla frutescens var. arguta
H0535 Teng Wu Jia Gen藤五加根 NAAcanthopanax gracilistylus
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0688 Xuan Shen玄参 Ningpo figwortScrophularia ningpoensis
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0573 Tu Jia Pi土加皮 NAAcanthopanax gracilistylus
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0715 Che Qian Zi车前子 seed of asiatic pantainPlantago asiatica
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0849 Zi Su Geng紫苏梗 Common perilla stemPerilla frutescens var. arguta
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0409 Shan Jiang山姜 shell gingerAlpinia zerumbet
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0768 Yuan Shen元参 Figwort rootScrophularia ningpoensis
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H1232 Huang Cao Wu黄草乌 NAAconitum vilmorinianum
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0740 Yi Zhi益智 Fructus alpinae oxyphyllaeAlpinia oxyphylla
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1110 Gua Lou Zi瓜蒌子 mongolian snakegourd seedTrichosanthes kirilowii maxim
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0249 Bei Ting Li Zi北葶苈子 Descurainia sophiaLepidium apetalum
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H0557 Ting Li Cao葶苈草 Descurainia sophiaLepidium apetalum
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0416 Shan Shen山参 NAPanax ginseng
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0204 Ma Ren麻仁 NACannabis sativa