Herb Description
| Herb ID: H1173 | Chinese Character: 黑丑 |
| English Name: Pharbitis seed | Latin Name: Semen pharbitidis |
| Chinese Pin Yin : Hei Chou | TCM-ID: TCMH829 |
| Therapeutic Function in Chinese : 泻下 | Therapeutic Function in English: Purging |
| Herb Function: Cause drastic purgation for clearing away retained fluid, and kill worms | |
Related Targets (Total: 207)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
2 Reference(s) |
| T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
3 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
3 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
5 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
2 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
1 Reference(s) |
| T97UTI | 6-phosphogluconate dehydrogenase, decarboxylating | PGD |
P52209 |
2 Reference(s) |
| T76PKX | Mast/stem cell growth factor receptor Kit | KIT |
P10721 |
1 Reference(s) |
| T40DIM | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 |
P28845 |
1 Reference(s) |
| T54VET | Protein tyrosine phosphatase type IVA 3 | PTP4A3 |
O75365 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
7 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
3 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
4 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
| T12RJE | Casein kinase II subunit alpha' | CSNK2A2 |
P19784 |
1 Reference(s) |
| T47C6A | Phosphoglycerate mutase 1 | PGAM1 |
P18669 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
3 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
4 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
1 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
3 Reference(s) |
| T74WWP | Peroxisome proliferator-activated receptor delta | PPARD |
Q03181 |
1 Reference(s) |
| T14JSX | Plasminogen | PLG |
P00747 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
3 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
5 Reference(s) |
| T67LRH | RNA-binding protein Musashi homolog 1 | MSI1 |
O43347 |
1 Reference(s) |
| T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
2 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T55L5P | Macrophage scavenger receptor types I and II | MSR1 |
P21757 |
1 Reference(s) |
| T08U92 | Mitochondrial brown fat uncoupling protein 1 | UCP1 |
P25874 |
1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
1 Reference(s) |
| T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
2 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
8 Reference(s) |
| T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
12 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
3 Reference(s) |
| T47HTN | Prostaglandin E synthase | PTGES |
O14684 |
2 Reference(s) |
| T91MWA | Disintegrin and metalloproteinase domain-containing protein 17 | ADAM17 |
P78536 |
1 Reference(s) |
| T95K8Q | Intestinal-type alkaline phosphatase | ALPI |
P09923 |
1 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
3 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
3 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
2 Reference(s) |
| T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
2 Reference(s) |
| T54X6V | Intermediate conductance calcium-activated potassium channel protein 4 | KCNN4 |
O15554 |
1 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
| T91T8I | Glucose-6-phosphatase catalytic subunit 1 | G6PC1 |
P35575 |
1 Reference(s) |
| T31ZFD | Aldehyde oxidase | AOX1 |
Q06278 |
1 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
3 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
3 Reference(s) |
| T50SJ8 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | PRKAA2 |
P54646 |
1 Reference(s) |
| T37G49 | Platelet-activating factor acetylhydrolase | PLA2G7 |
Q13093 |
1 Reference(s) |
| T05TS9 | Cocaine esterase | CES2 |
O00748 |
1 Reference(s) |
| T77PFO | Histone deacetylase 6 | HDAC6 |
Q9UBN7 |
1 Reference(s) |
| T18LX5 | Neutrophil elastase | ELANE |
P08246 |
1 Reference(s) |
| T03XRZ | Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) | PTP4A1 |
Q93096 |
1 Reference(s) |
| T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
2 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
6 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
2 Reference(s) |
| T58FWN | Tyrosine-protein kinase BTK | BTK |
Q06187 |
1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
8 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
1 Reference(s) |
| T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
1 Reference(s) |
| T84WE9 | Vascular endothelial growth factor receptor 1 | FLT1 |
P17948 |
1 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
1 Reference(s) |
| T29JZ3 | Vascular endothelial growth factor receptor 3 | FLT4 |
P35916 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
2 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
2 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
1 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
3 Reference(s) |
| T39YFG | Trypsin-1 | PRSS1 |
P07477 |
1 Reference(s) |
| T54WR0 | Fatty acid-binding protein 5 | FABP5 |
Q01469 |
1 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
2 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
2 Reference(s) |
| T07S0E | BDNF/NT-3 growth factors receptor | NTRK2 |
Q16620 |
1 Reference(s) |
| T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
| T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
1 Reference(s) |
| T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
1 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
| T23YZF | Peptidyl-glycine alpha-amidating monooxygenase | PAM |
P19021 |
1 Reference(s) |
| T77FOL | Neuromodulin | GAP43 |
P17677 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
2 Reference(s) |
| T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
| T02DEN | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide | GCG |
P01275 |
2 Reference(s) |
| T48UT8 | Cholesteryl ester transfer protein | CETP |
P11597 |
1 Reference(s) |
| T32HPO | Aspartyl aminopeptidase | DNPEP |
Q9ULA0 |
1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T02YLA | Alpha-lactalbumin | LALBA |
P00709 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
2 Reference(s) |
| T96DNP | Nucleic acid dioxygenase ALKBH1 | ALKBH1 |
Q13686 |
1 Reference(s) |
| T13HYI | Alpha-ketoglutarate-dependent dioxygenase FTO | FTO |
Q9C0B1 |
1 Reference(s) |
| T31M1Q | Neuroserpin | SERPINI1 |
Q99574 |
1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
2 Reference(s) |
| T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
3 Reference(s) |
| T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
2 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
2 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
4 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
2 Reference(s) |
| T93R42 | Dipeptidyl peptidase 1 | CTSC |
P53634 |
1 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
| T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
2 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
2 Reference(s) |
| T12WTT | Interleukin-5 | IL5 |
P05113 |
1 Reference(s) |
| T50GQE | Interleukin-13 | IL13 |
P35225 |
1 Reference(s) |
| T86YQL | Prolactin | PRL |
P01236 |
1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T80XW6 | Scavenger receptor class B member 1 | SCARB1 |
Q8WTV0 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
2 Reference(s) |
| T76TED | Pro-opiomelanocortin | POMC |
P01189 |
1 Reference(s) |
| T37JN5 | Neutrophil gelatinase-associated lipocalin | LCN2 |
P80188 |
1 Reference(s) |
| T14ENF | Microtubule-associated protein 2 | MAP2 |
P11137 |
2 Reference(s) |
| T44KU9 | Cytochrome P450 2B6 | CYP2B6 |
P20813 |
1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
| T16Q09 | Bcl-2 homologous antagonist/killer | BAK1 |
Q16611 |
1 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
1 Reference(s) |
| T51EKP | Apolipoprotein M | APOM |
O95445 |
1 Reference(s) |
| T07VV7 | Guanylin | GUCA2A |
Q02747 |
1 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
| T80WPU | Protein ABHD15 | ABHD15 |
Q6UXT9 |
1 Reference(s) |
| T56OUM | 14-3-3 protein zeta/delta | YWHAZ |
P63104 |
1 Reference(s) |
| T24YWQ | Insulin-degrading enzyme | IDE |
P14735 |
1 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
2 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
2 Reference(s) |
| T18CUI | Neuron-specific calcium-binding protein hippocalcin | HPCA |
P84074 |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
1 Reference(s) |
| T08SJX | Astrocytic phosphoprotein PEA-15 | PEA15 |
Q15121 |
1 Reference(s) |
| T38OQ4 | Peroxiredoxin-2 | PRDX2 |
P32119 |
1 Reference(s) |
| T38J3Y | Gamma-enolase | ENO2 |
P09104 |
1 Reference(s) |
| T52CKD | Pro-epidermal growth factor | EGF |
P01133 |
1 Reference(s) |
| T42PUG | Solute carrier family 2, facilitated glucose transporter member 1 | SLC2A1 |
P11166 |
1 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
1 Reference(s) |
| T95K0K | Interferon alpha-1/13 | IFNA1; IFNA13 |
P01562 |
1 Reference(s) |
| T64LKA | Bile salt export pump | ABCB11 |
O95342 |
2 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
1 Reference(s) |
| T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
1 Reference(s) |
| T84CEG | Claudin-5 | CLDN5 |
O00501 |
1 Reference(s) |
| T30AEN | Aquaporin-5 | AQP5 |
P55064 |
1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
1 Reference(s) |
| T47RAK | NA | MIR145 |
NA |
1 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
1 Reference(s) |
| T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
1 Reference(s) |
| T37SV3 | Occludin | OCLN |
Q16625 |
1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
1 Reference(s) |
| T69F5W | Forkhead box protein D3 | FOXD3 |
Q9UJU5 |
1 Reference(s) |
| T13I7C | Transforming growth factor beta-2 proprotein | TGFB2 |
P61812 |
2 Reference(s) |
| T44EUX | Fragile X mental retardation syndrome-related protein 1 | FXR1 |
P51114 |
1 Reference(s) |
| T92LK2 | Tumor necrosis factor ligand superfamily member 10 | TNFSF10 |
P50591 |
1 Reference(s) |
| T11FH6 | Phosphatidylinositol 3-kinase regulatory subunit alpha | PIK3R1 |
P27986 |
1 Reference(s) |
| T67RBZ | Mitochondrial uncoupling protein 2 | UCP2 |
P55851 |
2 Reference(s) |
| T67HYX | Mitochondrial uncoupling protein 3 | UCP3 |
P55916 |
1 Reference(s) |
| T19EKF | Cholecystokinin | CCK |
P06307 |
1 Reference(s) |
| T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
1 Reference(s) |
| T23APZ | Retinol-binding protein 2 | RBP2 |
P50120 |
1 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
1 Reference(s) |
| T03NWF | Sterol O-acyltransferase 1 | SOAT1 |
P35610 |
1 Reference(s) |
| T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
1 Reference(s) |
| T53SLQ | Aquaporin-9 | AQP9 |
O43315 |
1 Reference(s) |
| T75EH8 | Glucagon-like peptide 1 receptor | GLP1R |
P43220 |
2 Reference(s) |
| T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
1 Reference(s) |
| T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
| T91UNL | Keratin, type I cytoskeletal 14 | KRT14 |
P02533 |
1 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
| T08OEP | Monocyte differentiation antigen CD14 | CD14 |
P08571 |
1 Reference(s) |
| T32IXS | Integrin alpha-M | ITGAM |
P11215 |
1 Reference(s) |
| T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
| T62ERY | Interleukin-1 receptor-associated kinase 4 | IRAK4 |
Q9NWZ3 |
1 Reference(s) |
| T76AZQ | Histidine decarboxylase | HDC |
P19113 |
1 Reference(s) |
| T36I66 | Metallothionein-2 | MT2A |
P02795 |
1 Reference(s) |
| T45WII | Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide | TGFB3 |
P10600 |
1 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
1 Reference(s) |
| T28DIY | Immunoglobulin heavy constant epsilon | IGHE |
P01854 |
1 Reference(s) |
| T02HSM | Neuroglobin | NGB |
Q9NPG2 |
1 Reference(s) |
| T70HC9 | Hepatocyte nuclear factor 1-alpha | HNF1A |
P20823 |
1 Reference(s) |
| T49J7I | Hepatocyte nuclear factor 4-alpha | HNF4A |
P41235 |
1 Reference(s) |
| T54B00 | P2X purinoceptor 7 | P2RX7 |
Q99572 |
1 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
1 Reference(s) |
| T98DNG | Natriuretic peptides A | NPPA |
P01160 |
1 Reference(s) |
| T78ILO | Stearoyl-CoA desaturase | SCD |
O00767 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T68IZC | Natriuretic peptides B | NPPB |
P16860 |
1 Reference(s) |
| T02H9U | Nuclear factor of activated T-cells, cytoplasmic 4 | NFATC4 |
Q14934 |
1 Reference(s) |
| T66JU3 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | SRD5A2 |
P31213 |
1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
1 Reference(s) |
| T92WFW | C-C motif chemokine 3 | CCL3 |
P10147 |
1 Reference(s) |
| T96N1K | Calcium/calmodulin-dependent protein kinase type IV | CAMK4 |
Q16566 |
1 Reference(s) |
| T04V7K | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | ENPP7 |
Q6UWV6 |
1 Reference(s) |
| T51U9M | Carnitine O-palmitoyltransferase 1, muscle isoform | CPT1B |
Q92523 |
1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
1 Reference(s) |
Related Compounds (Total: 22)
C0251
Name: Nonane
C0285
Name: Palmitic Acid
C0073
Name: Ferulic Acid
C0306
Name: Physcion
C0041
Name: Emodin
key description of the interaction between compound and target