HIT-result

Target Description

Type	Detail
Target ID	T13HYI
Protein Name	Alpha-ketoglutarate-dependent dioxygenase FTO
Uniprot ID	Q9C0B1
Protein Name Alias	Fat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; EC 1.14.11.-; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; EC 1.14.11.-; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethylase FTO; EC 1.14.11.-; mRNA N(6)-methyladenosine demethylase FTO; EC 1.14.11.53; tRNA N1-methyl adenine demethylase FTO; EC 1.14.11.-
Gene ID	79068
Gene Symbol	FTO
Gene Alias	KIAA1752
TTD	NA
Pfam	PF12933 ; PF12934
GO	0005634:nucleus 0070989:oxidative demethylation 0090335:regulation of brown fat cell differentiation 0005829:cytosol 0035516:oxidative DNA demethylase activity 0035515:oxidative RNA demethylase activity 1990984:tRNA demethylase activity 0061157:mRNA destabilization 1990931:RNA N6-methyladenosine dioxygenase activity 0035553:oxidative single-stranded RNA demethylation 0005886:plasma membrane 0043231:intracellular membrane-bounded organelle 0006307:DNA dealkylation involved in DNA repair 0008198:ferrous iron binding 0040014:regulation of multicellular organism growth 0035552:oxidative single-stranded DNA demethylation 0005737:cytoplasm 0016740:transferase activity 0043734:DNA-N1-methyladenine dioxygenase activity 0010883:regulation of lipid storage 0042245:RNA repair 0005654:nucleoplasm 0080111:DNA demethylation 0016607:nuclear speck
PDB	6AKW ; 4IE6 ; 5DAB ; 4CXX ; 5ZMD ; 4ZS2 ; 4IDZ ; 3LFM ; 4IE5 ; 4IE0 ; 6AK4 ; 4CXY ; 4QHO ; 4QKN ; 4IE7 ; 4ZS3 ; 4CXW ; 4IE4 ; 5F8P ; 6AEJ
Drugbank	DB11638
KEGG	hsa:79068

Type

Detail

Target ID

T13HYI

Protein Name

Alpha-ketoglutarate-dependent dioxygenase FTO

Uniprot ID

Q9C0B1

Protein Name Alias

Fat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; EC 1.14.11.-; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; EC 1.14.11.-; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethylase FTO; EC 1.14.11.-; mRNA N(6)-methyladenosine demethylase FTO; EC 1.14.11.53; tRNA N1-methyl adenine demethylase FTO; EC 1.14.11.-

Gene ID

79068

Gene Symbol

FTO

Gene Alias

KIAA1752

TTD

Pfam

PF12933 ; PF12934

0005634:nucleus

0070989:oxidative demethylation

0090335:regulation of brown fat cell differentiation

0005829:cytosol

0035516:oxidative DNA demethylase activity

0035515:oxidative RNA demethylase activity

1990984:tRNA demethylase activity

0061157:mRNA destabilization

1990931:RNA N6-methyladenosine dioxygenase activity

0035553:oxidative single-stranded RNA demethylation

0005886:plasma membrane

0043231:intracellular membrane-bounded organelle

0006307:DNA dealkylation involved in DNA repair

0008198:ferrous iron binding

0040014:regulation of multicellular organism growth

0035552:oxidative single-stranded DNA demethylation

0005737:cytoplasm

0016740:transferase activity

0043734:DNA-N1-methyladenine dioxygenase activity

0010883:regulation of lipid storage

0042245:RNA repair

0005654:nucleoplasm

0080111:DNA demethylation

0016607:nuclear speck

PDB

6AKW ; 4IE6 ; 5DAB ; 4CXX ; 5ZMD ; 4ZS2 ; 4IDZ ; 3LFM ; 4IE5 ; 4IE0 ; 6AK4 ; 4CXY ; 4QHO ; 4QKN ; 4IE7 ; 4ZS3 ; 4CXW ; 4IE4 ; 5F8P ; 6AEJ

Drugbank

DB11638

KEGG

hsa:79068

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0102	Jue Ming Zi	决明子	Sickle senna seed	Cassia tora
H1000	Dong Gua Zi	冬瓜子	Chinese waxgourd seed	Benincasa hispida
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0632	Xia Ku Cao	夏枯草	Common selfheal	Prunella vulgaris
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H1011	Bai Chou	白丑	Pharbitis seed	Semen pharbitidis
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H1173	Hei Chou	黑丑	Pharbitis seed	Semen pharbitidis
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0387	San Ya Ku	三桠苦	Common rue	Ruta graveolens
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0774	Yun Xiang Jin Gao	芸香浸膏	Ruta	Ruta graveolens
H0540	Tian Ji Huang	田基黄	all - grass of japanese st. johnswort	Grangea maderaspatana
H0998	Dong Gua Pi	冬瓜皮	Chinese waxgourd peel	Benincasa hispida
H0685	Xuan Cao Gen	萱草根	Orange daylily	Hemerocallis fulva

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 18)