Herb Description

Herb ID:   H1011 Chinese Character:   白丑
English Name:  Pharbitis seed Latin Name:  Semen pharbitidis
Chinese Pin Yin :  Bai Chou TCM-ID:  TCMH52
Therapeutic Function in Chinese :  泻下 Therapeutic Function in English:  Purging
Herb Function:  Cause drastic purgation for clearing away retained fluid, and kill worms

Related Targets  (Total: 207)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T22NX4 Toll-like receptor 2TLR2 O60603
2 Reference(s)
T76QBQ CREB-regulated transcription coactivator 2CRTC2 Q53ET0
1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
3 Reference(s)
T25Y64 CholinesteraseBCHE P06276
3 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
5 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
2 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
1 Reference(s)
T97UTI 6-phosphogluconate dehydrogenase, decarboxylatingPGD P52209
2 Reference(s)
T76PKX Mast/stem cell growth factor receptor KitKIT P10721
1 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
1 Reference(s)
T54VET Protein tyrosine phosphatase type IVA 3PTP4A3 O75365
1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
7 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
3 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
4 Reference(s)
T20JZ2 Androgen receptorAR P10275
1 Reference(s)
T12RJE Casein kinase II subunit alpha'CSNK2A2 P19784
1 Reference(s)
T47C6A Phosphoglycerate mutase 1PGAM1 P18669
1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
3 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
4 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
1 Reference(s)
T62P0D Collagenase 3MMP13 P45452
1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
3 Reference(s)
T74WWP Peroxisome proliferator-activated receptor deltaPPARD Q03181
1 Reference(s)
T14JSX PlasminogenPLG P00747
1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
3 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
5 Reference(s)
T67LRH RNA-binding protein Musashi homolog 1MSI1 O43347
1 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
2 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
2 Reference(s)
T55L5P Macrophage scavenger receptor types I and IIMSR1 P21757
1 Reference(s)
T08U92 Mitochondrial brown fat uncoupling protein 1UCP1 P25874
1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
1 Reference(s)
T46YMA Ras-related C3 botulinum toxin substrate 1RAC1 P63000
2 Reference(s)
T85U8U Caspase-3CASP3 P42574
8 Reference(s)
T14LSK E3 ubiquitin-protein ligase XIAPXIAP P98170
12 Reference(s)
T56TXY Polyunsaturated fatty acid 5-lipoxygenaseALOX5 P09917
3 Reference(s)
T47HTN Prostaglandin E synthasePTGES O14684
2 Reference(s)
T91MWA Disintegrin and metalloproteinase domain-containing protein 17ADAM17 P78536
1 Reference(s)
T95K8Q Intestinal-type alkaline phosphataseALPI P09923
1 Reference(s)
T31U13 Cytochrome P450 2C19CYP2C19 P33261
1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
3 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
3 Reference(s)
T09BRP NAPKB_RS07820 NA
2 Reference(s)
T11ZYR Cytochrome P450 2D6CYP2D6 P10635
1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
2 Reference(s)
T54X6V Intermediate conductance calcium-activated potassium channel protein 4KCNN4 O15554
1 Reference(s)
T12PIB Lysosomal alpha-glucosidaseGAA P10253
1 Reference(s)
T91T8I Glucose-6-phosphatase catalytic subunit 1G6PC1 P35575
1 Reference(s)
T31ZFD Aldehyde oxidaseAOX1 Q06278
1 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
3 Reference(s)
T23P74 Caspase-9CASP9 P55211
3 Reference(s)
T50SJ8 5'-AMP-activated protein kinase catalytic subunit alpha-2PRKAA2 P54646
1 Reference(s)
T37G49 Platelet-activating factor acetylhydrolasePLA2G7 Q13093
1 Reference(s)
T05TS9 Cocaine esteraseCES2 O00748
1 Reference(s)
T77PFO Histone deacetylase 6HDAC6 Q9UBN7
1 Reference(s)
T18LX5 Neutrophil elastaseELANE P08246
1 Reference(s)
T03XRZ Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)PTP4A1 Q93096
1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
2 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
6 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
2 Reference(s)
T58FWN Tyrosine-protein kinase BTKBTK Q06187
1 Reference(s)
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
8 Reference(s)
T01QLH Estrogen receptorESR1 P03372
1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
1 Reference(s)
T27U96 Granulocyte-macrophage colony-stimulating factorCSF2 P04141
1 Reference(s)
T84WE9 Vascular endothelial growth factor receptor 1FLT1 P17948
1 Reference(s)
T04MBA Vascular endothelial growth factor receptor 2KDR P35968
1 Reference(s)
T29JZ3 Vascular endothelial growth factor receptor 3FLT4 P35916
1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
2 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
2 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
3 Reference(s)
T39YFG Trypsin-1PRSS1 P07477
1 Reference(s)
T54WR0 Fatty acid-binding protein 5FABP5 Q01469
1 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
2 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
2 Reference(s)
T07S0E BDNF/NT-3 growth factors receptorNTRK2 Q16620
1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
1 Reference(s)
T51WGR Pancreas/duodenum homeobox protein 1PDX1 P52945
1 Reference(s)
T43NBB Solute carrier family 2, facilitated glucose transporter member 2SLC2A2 P11168
1 Reference(s)
T89L4V InsulinINS P01308
1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
1 Reference(s)
T23YZF Peptidyl-glycine alpha-amidating monooxygenasePAM P19021
1 Reference(s)
T77FOL NeuromodulinGAP43 P17677
1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
2 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
1 Reference(s)
T02DEN Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptideGCG P01275
2 Reference(s)
T48UT8 Cholesteryl ester transfer proteinCETP P11597
1 Reference(s)
T32HPO Aspartyl aminopeptidaseDNPEP Q9ULA0
1 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
1 Reference(s)
T02YLA Alpha-lactalbuminLALBA P00709
1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
2 Reference(s)
T96DNP Nucleic acid dioxygenase ALKBH1ALKBH1 Q13686
1 Reference(s)
T13HYI Alpha-ketoglutarate-dependent dioxygenase FTOFTO Q9C0B1
1 Reference(s)
T31M1Q NeuroserpinSERPINI1 Q99574
1 Reference(s)
T00CXT Prostaglandin G/H synthase 1PTGS1 P23219
1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
2 Reference(s)
T99XQ3 DNA topoisomerase 1TOP1 P11387
1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
3 Reference(s)
T68BGR Glial fibrillary acidic proteinGFAP P14136
2 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
4 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
2 Reference(s)
T93R42 Dipeptidyl peptidase 1CTSC P53634
1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
1 Reference(s)
T70HTD Cytochrome P450 2E1CYP2E1 P05181
2 Reference(s)
T50V79 Interleukin-4IL4 P05112
2 Reference(s)
T12WTT Interleukin-5IL5 P05113
1 Reference(s)
T50GQE Interleukin-13IL13 P35225
1 Reference(s)
T86YQL ProlactinPRL P01236
1 Reference(s)
T17CZC Tissue factorF3 P13726
1 Reference(s)
T13KGH TyrosinaseTYR P14679
1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
1 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
1 Reference(s)
T38T1U Caspase-8CASP8 Q14790
1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
2 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
1 Reference(s)
T37JN5 Neutrophil gelatinase-associated lipocalinLCN2 P80188
1 Reference(s)
T14ENF Microtubule-associated protein 2MAP2 P11137
2 Reference(s)
T44KU9 Cytochrome P450 2B6CYP2B6 P20813
1 Reference(s)
T75H3W Cyclin-dependent kinase 2CDK2 P24941
1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
1 Reference(s)
T10S5F Cyclin-dependent kinase 4CDK4 P11802
1 Reference(s)
T16Q09 Bcl-2 homologous antagonist/killerBAK1 Q16611
1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
1 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
1 Reference(s)
T07VV7 GuanylinGUCA2A Q02747
1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
1 Reference(s)
T80WPU Protein ABHD15ABHD15 Q6UXT9
1 Reference(s)
T56OUM 14-3-3 protein zeta/deltaYWHAZ P63104
1 Reference(s)
T24YWQ Insulin-degrading enzymeIDE P14735
1 Reference(s)
T60UPF Parvalbumin alphaPVALB P20472
2 Reference(s)
T69RXK Cytochrome P450 2C9CYP2C9 P11712
2 Reference(s)
T18CUI Neuron-specific calcium-binding protein hippocalcinHPCA P84074
1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
1 Reference(s)
T39RV3 Dual specificity mitogen-activated protein kinase kinase 1MAP2K1 Q02750
1 Reference(s)
T66S13 Dual specificity mitogen-activated protein kinase kinase 2MAP2K2 P36507
1 Reference(s)
T08SJX Astrocytic phosphoprotein PEA-15PEA15 Q15121
1 Reference(s)
T38OQ4 Peroxiredoxin-2PRDX2 P32119
1 Reference(s)
T38J3Y Gamma-enolaseENO2 P09104
1 Reference(s)
T52CKD Pro-epidermal growth factorEGF P01133
1 Reference(s)
T42PUG Solute carrier family 2, facilitated glucose transporter member 1SLC2A1 P11166
1 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
1 Reference(s)
T95K0K Interferon alpha-1/13IFNA1; IFNA13 P01562
1 Reference(s)
T64LKA Bile salt export pumpABCB11 O95342
2 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
1 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
1 Reference(s)
T84CEG Claudin-5CLDN5 O00501
1 Reference(s)
T30AEN Aquaporin-5AQP5 P55064
1 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
1 Reference(s)
T47RAK NAMIR145 NA
1 Reference(s)
T75NEV Aquaporin-1AQP1 P29972
1 Reference(s)
T54SZZ Endoplasmic reticulum chaperone BiPHSPA5 P11021
1 Reference(s)
T37SV3 OccludinOCLN Q16625
1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
1 Reference(s)
T69F5W Forkhead box protein D3FOXD3 Q9UJU5
1 Reference(s)
T13I7C Transforming growth factor beta-2 proproteinTGFB2 P61812
2 Reference(s)
T44EUX Fragile X mental retardation syndrome-related protein 1FXR1 P51114
1 Reference(s)
T92LK2 Tumor necrosis factor ligand superfamily member 10TNFSF10 P50591
1 Reference(s)
T11FH6 Phosphatidylinositol 3-kinase regulatory subunit alphaPIK3R1 P27986
1 Reference(s)
T67RBZ Mitochondrial uncoupling protein 2UCP2 P55851
2 Reference(s)
T67HYX Mitochondrial uncoupling protein 3UCP3 P55916
1 Reference(s)
T19EKF CholecystokininCCK P06307
1 Reference(s)
T19XSL Fatty acid-binding protein, liverFABP1 P07148
1 Reference(s)
T23APZ Retinol-binding protein 2RBP2 P50120
1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
1 Reference(s)
T03NWF Sterol O-acyltransferase 1SOAT1 P35610
1 Reference(s)
T48YPL Aquaporin-3AQP3 Q92482
1 Reference(s)
T53SLQ Aquaporin-9AQP9 O43315
1 Reference(s)
T75EH8 Glucagon-like peptide 1 receptorGLP1R P43220
2 Reference(s)
T52VL6 Signal transducer and activator of transcription 5ASTAT5A P42229
1 Reference(s)
T19K8W Signal transducer and activator of transcription 5BSTAT5B P51692
1 Reference(s)
T91UNL Keratin, type I cytoskeletal 14KRT14 P02533
1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
1 Reference(s)
T08OEP Monocyte differentiation antigen CD14CD14 P08571
1 Reference(s)
T32IXS Integrin alpha-MITGAM P11215
1 Reference(s)
T07NML P-selectinSELP P16109
1 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
1 Reference(s)
T62ERY Interleukin-1 receptor-associated kinase 4IRAK4 Q9NWZ3
1 Reference(s)
T76AZQ Histidine decarboxylaseHDC P19113
1 Reference(s)
T36I66 Metallothionein-2MT2A P02795
1 Reference(s)
T45WII Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptideTGFB3 P10600
1 Reference(s)
T74I49 Bcl-2-like protein 1BCL2L1 Q07817
1 Reference(s)
T28DIY Immunoglobulin heavy constant epsilonIGHE P01854
1 Reference(s)
T02HSM NeuroglobinNGB Q9NPG2
1 Reference(s)
T70HC9 Hepatocyte nuclear factor 1-alphaHNF1A P20823
1 Reference(s)
T49J7I Hepatocyte nuclear factor 4-alphaHNF4A P41235
1 Reference(s)
T54B00 P2X purinoceptor 7P2RX7 Q99572
1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
1 Reference(s)
T98DNG Natriuretic peptides ANPPA P01160
1 Reference(s)
T78ILO Stearoyl-CoA desaturaseSCD O00767
1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
1 Reference(s)
T68IZC Natriuretic peptides BNPPB P16860
1 Reference(s)
T02H9U Nuclear factor of activated T-cells, cytoplasmic 4NFATC4 Q14934
1 Reference(s)
T66JU3 3-oxo-5-alpha-steroid 4-dehydrogenase 2SRD5A2 P31213
1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
1 Reference(s)
T92WFW C-C motif chemokine 3CCL3 P10147
1 Reference(s)
T96N1K Calcium/calmodulin-dependent protein kinase type IVCAMK4 Q16566
1 Reference(s)
T04V7K Ectonucleotide pyrophosphatase/phosphodiesterase family member 7ENPP7 Q6UWV6
1 Reference(s)
T51U9M Carnitine O-palmitoyltransferase 1, muscle isoformCPT1B Q92523
1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
1 Reference(s)

Related Compounds  (Total: 22)

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C0251
Name: Nonane
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C0285
Name: Palmitic Acid
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C0073
Name: Ferulic Acid
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C0306
Name: Physcion
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C0041
Name: Emodin