Target Description

Type Detail
Target ID T54X6V
Protein Name Intermediate conductance calcium-activated potassium channel protein 4
Uniprot ID O15554
Protein Name Alias SK4;  SKCa 4;  SKCa4;  IKCa1;  IK1;  KCa3.1;  KCa4;  Putative Gardos channel
Gene ID 3783
Gene Symbol KCNN4
Gene Alias IK1;  IKCA1;  KCA4;  SK4
TTD T42724: Clinical Trial target
Pfam PF07885 ; PF03530 ; PF02888
GO
0016286:small conductance calcium-activated potassium channel activity

0006811:ion transport

0006816:calcium ion transport

0050714:positive regulation of protein secretion

0006884:cell volume homeostasis

1901381:positive regulation of potassium ion transmembrane transport

0006952:defense response

0045332:phospholipid translocation

0005886:plasma membrane

0030322:stabilization of membrane potential

0050862:positive regulation of T cell receptor signaling pathway

0031982:vesicle

0008076:voltage-gated potassium channel complex

0046541:saliva secretion

0005516:calmodulin binding

0022894:Intermediate conductance calcium-activated potassium channel activity

0071805:potassium ion transmembrane transport

0002376:immune system process

0006813:potassium ion transport

0043025:neuronal cell body

0043005:neuron projection

0015269:calcium-activated potassium channel activity

0019903:protein phosphatase binding

PDB 6CNO ; 6D42 ; 6CNM ; 6CNN
Drugbank DB00721 ; DB00468 ; DB01110 ; DB01159 ; DB00257 ; DB09089
KEGG hsa:3783

Related Compounds  (Total: 2)

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C0363
Name: Resveratrol
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C1203
Name: Caffeic Acid


Related Herbs  (Total: 187)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0448 Bo He You薄荷油 MintMentha haplocalyx
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H0612 Cao Shan Hu Jin Gao草珊瑚浸膏 NASarcandra glabra
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0050 Jin Gang Tou金刚头 NAGymnema sylvestre
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H0954 Dan Zhu Ye淡竹叶 Common lophatherumLophatherum gracile
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0892 Chuan Xiong川芎 cnidium officinaleCnidium officinale
H0416 Shan Shen山参 NAPanax ginseng
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0700 Ya Zhi Cao鸭跖草 Common dayflowerCommelina communis
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0778 Zao Jiao Ci皂角刺 spine of chinese honeylocustSpina gleditsiae
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0839 Zhua Di Hu抓地虎 ValerianValeriana officinalis
H0871 Chuan Duan川断 TeaselsDipsacus asper
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0779 Zao Jiao Zhen皂角针 Chinese honeylocust spineGleditsia sinensis
H0100 Juan Bai卷柏 Tamariskoid spikemossSelaginella tamariscina
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0576 Tu Mu Xiang土木香 Elecampane inulaInula helenium
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H1195 Bai Ma Gu白马骨 all - grass of snow of june.Herba serissae
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1061 Bai He百合 LilyLilium brownii
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0894 Chuan Xu Duan川续断 Himalayan teaselDipsacus asperoides
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0893 Chuan Xiong Jin Gao川芎浸膏 cnidium officinaleCnidium officinale
H0891 Chuan Xin Lian Ye穿心莲叶 Powder of green chiretta leavesAndrographis herba
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0357 Ren Shen人参 GinsengPanax ginseng
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H0741 Yi Zhi Hao一枝蒿 Alpine yarrow herbSolidago decurrens
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0147 Lie Dang列当 Skyblue broomrapeOrobanche coerulescens
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0777 Zao Jia皂荚 Chinese honeylocustGleditsia sinensis
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H1100 Gu Jing Cao谷精草 PipewartEriocaulon buergerianum
H0447 Sheng Ma升麻 BugbaneCimicifuga foetida
H0116 Kuan Ye Xie Cao宽叶缬草 NAValeriana officinalis
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0938 Da Suan大蒜 GarlicAllium sativum
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0241 Mi Hou Tao猕猴桃 Yangtao actinidiaActinidia chinensis
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0776 Zao Ci皂刺 spine of chinese honeylocustSpina gleditsiae
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0756 Ying Su罂粟 Opium poppyPapaver somniferum
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0534 Teng Li Gen藤梨根 NAActinidia arguta
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0075 Jing Mi粳米 RiceOryza sativa
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1201 Hu Er Cao虎耳草 Creeping rockfoilSaxifraga stolonifera
H1019 E Bu Shi Cao鹅不食草 Small centipedaCentipeda minima
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0509 Cang Er苍耳 Siberian cockleburXanthium sibiricum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0680 Xiong Dan熊胆 Bear gallConyza blinii
H0698 Ya Zao牙皂 Chinese honeylocust abnormal fruitGleditsia sinensis
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0514 Cang Er Cao苍耳草 Cocklebur grassXanthium sibiricum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0045 Jin Fei Cao金沸草 Japanese inulaInula japonica
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0772 Yue Ji Hua月季花 Chinese roseRosa chinensis
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0671 Xie Cao缬草 Common valerianaValeriana officinalis
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H1020 E Bu Shi Cao Nong Suo Ye鹅不食草浓缩液 Small centipedaCentipeda minima
H0083 Jiu Jie Cha九节茶 Glabrous sarcandraSarcandra glabra
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0115 Kuan Dong Hua款冬花 Common coltsfootTussilago farfara
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0440 Sheng Di Hong Jing Tian圣地红景天 Integripetal rhodiolaRhodiola sacra
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H0436 Bo He薄荷 Wild mintMentha haplocalyx
H1186 Hong Gen Cao红根草 Hispid sageSalvia prionitis
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0639 Xiang Cha Cai香茶菜 Common rabdosiaIsodon amethystoides
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0681 Xiong Dan Fen熊胆粉 Bear gallConyza blinii
H0243 Mi Kuan Dong Hua蜜款冬花 Common coltsfootTussilago farfara
H0566 Cao Cong Rong草苁蓉 Russian boschniakiaBoschniakia rossica
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0047 Jin Gang Teng金刚藤 NAGymnema sylvestre
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0185 Luo Shi Teng络石藤 Chinese star jasmineTrachelospermum jasminoides
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0817 Zhi Zhu Xiang蜘蛛香 Jatamans valerianaValeriana jatamansii