Herb ID: H0680 | Chinese Character: 熊胆 |
English Name: Bear gall | Latin Name: Conyza blinii |
Chinese Pin Yin : Xiong Dan | TCM-ID: TCMH2327 |
Therapeutic Function in Chinese : 清热 | Therapeutic Function in English: Heat clearence |
Herb Function: For clearing heat and removing toxic substances |
Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
---|---|---|---|---|
T43G0N | Cytochrome P450 2C8 | CYP2C8 |
P10632 |
1 Reference(s) |
T01FVG | DNA gyrase subunit B | gyrB |
P0AES6 |
1 Reference(s) |
T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
2 Reference(s) |
T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
3 Reference(s) |
T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
4 Reference(s) |
T30VNV | Myeloperoxidase | MPO |
P05164 |
1 Reference(s) |
T67JR8 | Heat shock factor protein 1 | HSF1 |
Q00613 |
2 Reference(s) |
T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
4 Reference(s) |
T51IKV | DNA topoisomerase 2-alpha | TOP2A |
P11388 |
1 Reference(s) |
T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
2 Reference(s) |
T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
3 Reference(s) |
T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
3 Reference(s) |
T46AQJ | Glutathione S-transferase P | GSTP1 |
P09211 |
3 Reference(s) |
T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
6 Reference(s) |
T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
5 Reference(s) |
T50SJ8 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | PRKAA2 |
P54646 |
1 Reference(s) |
T09DI4 | Lysine-specific histone demethylase 1A | KDM1A |
O60341 |
1 Reference(s) |
T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
2 Reference(s) |
T03YAI | Mitogen-activated protein kinase kinase kinase 5 | MAP3K5 |
Q99683 |
1 Reference(s) |
T39FBA | Thioredoxin-interacting protein | TXNIP |
Q9H3M7 |
1 Reference(s) |
T64BPL | Solute carrier family 23 member 1 | SLC23A1 |
Q9UHI7 |
1 Reference(s) |
T60KJ1 | Putative endoplasmin-like protein | HSP90B2P |
Q58FF3 |
2 Reference(s) |
T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
2 Reference(s) |
T13KGH | Tyrosinase | TYR |
P14679 |
3 Reference(s) |
T73LXA | Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1B | HSPA1A;HSPA1B |
P0DMV8;P0DMV9 |
2 Reference(s) |
T46K2X | Heat shock 70 kDa protein 4 | HSPA4 |
P34932 |
10 Reference(s) |
T31RKU | Glycerol kinase | GK |
P32189 |
1 Reference(s) |
T85JI5 | Vitamin D3 receptor | VDR |
P11473 |
3 Reference(s) |
T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
2 Reference(s) |
T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
4 Reference(s) |
T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
2 Reference(s) |
T65S3S | Tyrosine-protein kinase JAK2 | JAK2 |
O60674 |
2 Reference(s) |
T68OIU | CREB-regulated transcription coactivator 1 | CRTC1 |
Q6UUV9 |
1 Reference(s) |
T88BCB | Glycerol-3-phosphate phosphatase | PGP |
A6NDG6 |
1 Reference(s) |
T01E7W | Aurora kinase B | AURKB |
Q96GD4 |
1 Reference(s) |
T42PUG | Solute carrier family 2, facilitated glucose transporter member 1 | SLC2A1 |
P11166 |
2 Reference(s) |
T67MQU | Antileukoproteinase | SLPI |
P03973 |
1 Reference(s) |
T19CUN | Prothrombin | F2 |
P00734 |
2 Reference(s) |
T01IGB | Serine/threonine-protein kinase/endoribonuclease IRE2 | ERN2 |
Q76MJ5 |
1 Reference(s) |
T94H37 | Cadherin-1 | CDH1 |
P12830 |
1 Reference(s) |
T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
2 Reference(s) |
T70LAB | UDP-glucuronosyltransferase 1A9 | UGT1A9 |
O60656 |
1 Reference(s) |
T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
1 Reference(s) |
T01CL0 | Tyrosine-protein kinase Lyn | LYN |
P07948 |
1 Reference(s) |
T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
1 Reference(s) |
T90QV5 | Voltage-gated hydrogen channel 1 | HVCN1 |
Q96D96 |
1 Reference(s) |
T51K6D | Tyrosine-protein phosphatase non-receptor type 11 | PTPN11 |
Q06124 |
1 Reference(s) |
T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
1 Reference(s) |
T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
1 Reference(s) |
T03CZ8 | Catechol O-methyltransferase | COMT |
P21964 |
1 Reference(s) |
T61QXV | Nuclear respiratory factor 1 | NRF1 |
Q16656 |
1 Reference(s) |
T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
5 Reference(s) |
T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
3 Reference(s) |
T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
2 Reference(s) |
T25Y64 | Cholinesterase | BCHE |
P06276 |
1 Reference(s) |
T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
1 Reference(s) |
T09BRP | NA | PKB_RS07820 |
NA |
1 Reference(s) |
T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
1 Reference(s) |
T54X6V | Intermediate conductance calcium-activated potassium channel protein 4 | KCNN4 |
O15554 |
1 Reference(s) |
T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
T04TWI | CD40 ligand | CD40LG |
P29965 |
1 Reference(s) |
T94S85 | Collagen alpha-1(I) chain | COL1A1 |
P02452 |
1 Reference(s) |
T48XM4 | Glutathione S-transferase Mu 2 | GSTM2 |
P28161 |
1 Reference(s) |
T87WYU | Glutathione S-transferase Mu 1 | GSTM1 |
P09488 |
1 Reference(s) |
T23P74 | Caspase-9 | CASP9 |
P55211 |
1 Reference(s) |
T34DZ7 | Interleukin-2 | IL2 |
P60568 |
1 Reference(s) |
T71GRQ | Hexokinase-2 | HK2 |
P52789 |
1 Reference(s) |
T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
2 Reference(s) |
T66BXF | Transcription factor E2F2 | E2F2 |
Q14209 |
1 Reference(s) |
T26KIE | Transcription factor AP-1 | JUN |
P05412 |
9 Reference(s) |
T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
9 Reference(s) |
T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
11 Reference(s) |
T80OJF | Interstitial collagenase | MMP1 |
P03956 |
4 Reference(s) |
T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
2 Reference(s) |
T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
3 Reference(s) |
T44LWL | Transcription factor p65 | RELA |
Q04206 |
9 Reference(s) |
T65JYL | C-X-C motif chemokine 2 | CXCL2 |
P19875 |
2 Reference(s) |
T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
7 Reference(s) |
T23VMI | Tumor necrosis factor | TNF |
P01375 |
8 Reference(s) |
T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
4 Reference(s) |
T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
5 Reference(s) |
T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
2 Reference(s) |
T41INV | Nuclear receptor subfamily 1 group I member 3 | NR1I3 |
Q14994 |
1 Reference(s) |
T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
1 Reference(s) |
T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
4 Reference(s) |
T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
2 Reference(s) |
T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
7 Reference(s) |
T41TXS | Retinoblastoma-associated protein | RB1 |
P06400 |
2 Reference(s) |
T28EY5 | Serine/threonine-protein kinase Chk2 | CHEK2 |
O96017 |
1 Reference(s) |
T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
1 Reference(s) |
T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
3 Reference(s) |
T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
T33OPP | Interleukin-6 | IL6 |
P05231 |
2 Reference(s) |
T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
T54CIF | Interleukin-8 | CXCL8 |
P10145 |
2 Reference(s) |
T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
8 Reference(s) |
T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
7 Reference(s) |
T85U8U | Caspase-3 | CASP3 |
P42574 |
13 Reference(s) |
T37VLU | Interferon gamma | IFNG |
P01579 |
1 Reference(s) |
T16A2X | Catalase | CAT |
P04040 |
2 Reference(s) |
T88B8X | Insulin receptor | INSR |
P06213 |
1 Reference(s) |
T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
1 Reference(s) |
T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
4 Reference(s) |
T00EP2 | Tissue-type plasminogen activator | PLAT |
P00750 |
4 Reference(s) |
T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
1 Reference(s) |
T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
3 Reference(s) |
T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
2 Reference(s) |
T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
3 Reference(s) |
T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
3 Reference(s) |
T06MQM | Heat shock protein beta-1 | HSPB1 |
P04792 |
2 Reference(s) |
T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
2 Reference(s) |
T90XYZ | C-reactive protein | CRP |
P02741 |
2 Reference(s) |
T05RAA | Inhibitor of nuclear factor kappa-B kinase subunit alpha | CHUK |
O15111 |
1 Reference(s) |
T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
2 Reference(s) |
T69NG6 | Interleukin-10 | IL10 |
P22301 |
2 Reference(s) |
T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
1 Reference(s) |
T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
1 Reference(s) |
T54VQA | Cyclin-dependent kinase inhibitor 2A | CDKN2A |
P42771 |
2 Reference(s) |
T55EFK | Transcription factor E2F1 | E2F1 |
Q01094 |
1 Reference(s) |
T23WMS | Cathepsin D | CTSD |
P07339 |
1 Reference(s) |
T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
3 Reference(s) |
T20JZ2 | Androgen receptor | AR |
P10275 |
2 Reference(s) |
T91EAB | Insulin-like growth factor-binding protein 3 | IGFBP3 |
P17936 |
2 Reference(s) |
T94YOD | Interferon regulatory factor 1 | IRF1 |
P10914 |
1 Reference(s) |
T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
4 Reference(s) |
T09AAD | NADPH--cytochrome P450 reductase | POR |
P16435 |
1 Reference(s) |
T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
1 Reference(s) |
T14JZK | Receptor tyrosine-protein kinase erbB-3 | ERBB3 |
P21860 |
2 Reference(s) |
T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
2 Reference(s) |
T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
T78VUO | RAF proto-oncogene serine/threonine-protein kinase | RAF1 |
P04049 |
1 Reference(s) |
T57GP2 | ETS domain-containing protein Elk-1 | ELK1 |
P19419 |
1 Reference(s) |
T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
1 Reference(s) |
T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
1 Reference(s) |
T52CKD | Pro-epidermal growth factor | EGF |
P01133 |
1 Reference(s) |
T16OQ5 | Puromycin-sensitive aminopeptidase | NPEPPS |
P55786 |
1 Reference(s) |
T08DOL | Sulfotransferase 1E1 | SULT1E1 |
P49888 |
1 Reference(s) |
T00H7Q | Neutrophil cytosol factor 1 | NCF1 |
P14598 |
1 Reference(s) |
T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
T37I29 | NA | VIM2P |
NA |
1 Reference(s) |
T77UWH | CCAAT/enhancer-binding protein beta | CEBPB |
P17676 |
1 Reference(s) |
T16MRU | NACHT, LRR and PYD domains-containing protein 3 | NLRP3 |
Q96P20 |
1 Reference(s) |
T54RF5 | DnaJ homolog subfamily C member 5 | DNAJC5 |
Q9H3Z4 |
1 Reference(s) |
T63DP6 | Heterogeneous nuclear ribonucleoprotein A1 | HNRNPA1 |
P09651 |
1 Reference(s) |
T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
3 Reference(s) |
T54N7G | Fos-related antigen 1 | FOSL1 |
P15407 |
1 Reference(s) |
T91OUC | Mucin-5AC | MUC5AC |
P98088 |
1 Reference(s) |
T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
2 Reference(s) |
T81MSV | Ubiquitin carboxyl-terminal hydrolase 10 | USP10 |
Q14694 |
1 Reference(s) |
T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
3 Reference(s) |
T03VS9 | Protein-tyrosine kinase 2-beta | PTK2B |
Q14289 |
1 Reference(s) |
T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
1 Reference(s) |
T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
1 Reference(s) |
T93R42 | Dipeptidyl peptidase 1 | CTSC |
P53634 |
1 Reference(s) |
T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
1 Reference(s) |
T23LHE | Claudin-4 | CLDN4 |
O14493 |
1 Reference(s) |
T63YAO | Caveolin-1 | CAV1 |
Q03135 |
1 Reference(s) |
T31G6V | Ras association domain-containing protein 1 | RASSF1 |
Q9NS23 |
1 Reference(s) |
T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
1 Reference(s) |
T79UQC | C-X-C motif chemokine 10 | CXCL10 |
P02778 |
1 Reference(s) |
T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
T50VJF | Osteopontin | SPP1 |
P10451 |
1 Reference(s) |
T31SX8 | Bone morphogenetic protein 2 | BMP2 |
P12643 |
1 Reference(s) |
T91MKC | Runt-related transcription factor 2 | RUNX2 |
Q13950 |
1 Reference(s) |
T17CZC | Tissue factor | F3 |
P13726 |
1 Reference(s) |
T84TJB | Homeobox protein Nkx-3.1 | NKX3-1 |
Q99801 |
1 Reference(s) |
T02WMA | Ornithine decarboxylase | ODC1 |
P11926 |
1 Reference(s) |
T38EQ6 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 |
P15559 |
1 Reference(s) |
T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
T17CNB | Thioredoxin | TXN |
P10599 |
2 Reference(s) |
T09KPZ | Vimentin | VIM |
P08670 |
1 Reference(s) |
T43LYL | X-box-binding protein 1 | XBP1 |
P17861 |
1 Reference(s) |
T00T9M | Thrombospondin-1 | THBS1 |
P07996 |
1 Reference(s) |
T61DYZ | Phospholipid-transporting ATPase ABCA1 | ABCA1 |
O95477 |
2 Reference(s) |
T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
1 Reference(s) |
T05WWN | Corticoliberin | CRH |
P06850 |
1 Reference(s) |
T47WT6 | Breast cancer type 1 susceptibility protein | BRCA1 |
P38398 |
1 Reference(s) |
T02M5I | Monocarboxylate transporter 1 | SLC16A1 |
P53985 |
1 Reference(s) |
T30L86 | Tumor necrosis factor receptor superfamily member 10B | TNFRSF10B |
O14763 |
1 Reference(s) |
T34Y7V | Carbohydrate-responsive element-binding protein | MLXIPL |
Q9NP71 |
1 Reference(s) |
T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
1 Reference(s) |
T76CGR | Pentraxin-related protein PTX3 | PTX3 |
P26022 |
1 Reference(s) |
T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
1 Reference(s) |
T91KTQ | Methyl-CpG-binding protein 2 | MECP2 |
P51608 |
1 Reference(s) |
T04HXV | Cytochrome b-c1 complex subunit 1, mitochondrial | UQCRC1 |
P31930 |
1 Reference(s) |
T86O9J | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | NDUFV2 |
P19404 |
1 Reference(s) |
T18DUA | Tight junction protein ZO-1 | TJP1 |
Q07157 |
2 Reference(s) |
T67JME | Gamma-aminobutyric acid receptor subunit rho-3 | GABRR3 |
A8MPY1 |
1 Reference(s) |
T67X1L | Eukaryotic translation initiation factor 2 subunit 1 | EIF2S1 |
P05198 |
1 Reference(s) |
T29JA7 | P2X purinoceptor 4 | P2RX4 |
Q99571 |
1 Reference(s) |
T97ESI | Apolipoprotein E | APOE |
P02649 |
1 Reference(s) |
T93NTV | Ketohexokinase | KHK |
P50053 |
1 Reference(s) |
T82S6C | Hexokinase-4 | GCK |
P35557 |
1 Reference(s) |
T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
T78ILO | Stearoyl-CoA desaturase | SCD |
O00767 |
1 Reference(s) |
T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
1 Reference(s) |
T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
1 Reference(s) |
T84CEG | Claudin-5 | CLDN5 |
O00501 |
1 Reference(s) |
T60XS5 | Lymphoid enhancer-binding factor 1 | LEF1 |
Q9UJU2 |
1 Reference(s) |
T52T5O | Axin-1 | AXIN1 |
O15169 |
1 Reference(s) |
T78EXU | Axin-2 | AXIN2 |
Q9Y2T1 |
1 Reference(s) |
T29B10 | Interleukin-17A | IL17A |
Q16552 |
1 Reference(s) |
T23KDW | Cyclic AMP-dependent transcription factor ATF-4 | ATF4 |
P18848 |
1 Reference(s) |
T31JWV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | PIK3CB |
P42338 |
1 Reference(s) |
T83QHM | Beta-nerve growth factor | NGF |
P01138 |
1 Reference(s) |
T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
1 Reference(s) |