Compound Description
| ID: C1203 | Common name: Caffeic Acid |
| IUPAC: (E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | CAS: CAS:331-39-5 |
| Chembl ID: CHEMBL145 | Pubchem ID: CID:689043 |
| Formula: C9H8O4 | TCM-ID: TCMC847 |
| Smiles: C1=CC(=C(C=C1C=CC(=O)O)O)O | |
| Alias:
Cinnamic acid, 3,4-dihydroxy-;
3-(3,4-Dihydroxyphenyl)-2-propenoic acid; 3,4-Dihydroxybenzeneacrylic acid; 3,4-Dihydroxycinnamic acid; 3-(3,4-Dihydroxyphenyl)propenoic acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene; 4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene; Caffeic acid; DHCA; NSC 57197; NSC 623438 |
Structure:
|
Related Targets (Total: 26)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
A | 2 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 2 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
A | 1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
A | 2 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
A | 1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
A | 1 Reference(s) |
| T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
A | 1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
A | 1 Reference(s) |
| T54X6V | Intermediate conductance calcium-activated potassium channel protein 4 | KCNN4 |
O15554 |
A | 1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
B | 1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
B | 1 Reference(s) |
| T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
B | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
B | 1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
B | 1 Reference(s) |
| T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
B | 1 Reference(s) |
| T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
B | 1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
B | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
B | 1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
B | 2 Reference(s) |
| T93R42 | Dipeptidyl peptidase 1 | CTSC |
P53634 |
B | 1 Reference(s) |
| T07NML | P-selectin | SELP |
P16109 |
C | 1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
C | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
C | 1 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 177)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0289 | Niu Bang Zi | 牛蒡子 | Great burdock fruit | Arctium lappa |
| H0566 | Cao Cong Rong | 草苁蓉 | Russian boschniakia | Boschniakia rossica |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0045 | Jin Fei Cao | 金沸草 | Japanese inula | Inula japonica |
| H0639 | Xiang Cha Cai | 香茶菜 | Common rabdosia | Isodon amethystoides |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H0043 | Jie Zi | 芥子 | India mustard seed | Brassica juncea |
| H0772 | Yue Ji Hua | 月季花 | Chinese rose | Rosa chinensis |
| H0436 | Bo He | 薄荷 | Wild mint | Mentha haplocalyx |
| H0418 | Shan Yin Chen | 山茵陈 | Capillary wormwood | Artemisia capillaris |
| H1051 | Bai Guo | 白果 | Ginkgo nut | Ginkgo biloba |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H0897 | Chuan Lian | 川楝 | Chinaberry | Melia azedarach |
| H0365 | Rou Dou Kou | 肉豆蔻 | Common nutmeg | Myristica fragrans |
| H0083 | Jiu Jie Cha | 九节茶 | Glabrous sarcandra | Sarcandra glabra |
| H0004 | Huo Xiang | 藿香 | Patchouli | Pogostemon cablin |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H1173 | Hei Chou | 黑丑 | Pharbitis seed | Semen pharbitidis |
| H0893 | Chuan Xiong Jin Gao | 川芎浸膏 | cnidium officinale | Cnidium officinale |
| H0844 | Zi Cao | 紫草 | Redroot gromwell | Lithospermum erythrorhizon |
| H0447 | Sheng Ma | 升麻 | Bugbane | Cimicifuga foetida |
| H0764 | Yu Xing Cao | 鱼腥草 | Heartleaf houttuynia | Houttuynia cordata |
| H0887 | Chuan Xin Lian Gan Jin Gao | 穿心莲干浸膏 | Common andrographis | Andrographis paniculata |
| H0756 | Ying Su | 罂粟 | Opium poppy | Papaver somniferum |
| H0690 | Xue Lian | 雪莲 | Snow lotus | Saussurea involucrata |
| H0064 | Jin Yin Hua | 金银花 | Japanese honeysuckle | Lonicera japonica |
| H1235 | Huang Hao | 黄蒿 | Virg ate wormwood | Artemisia scoparia |
| H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0181 | Luo Bu Ma | 罗布麻 | Dogbane | Apocynum venetum |
| H0601 | Wu Mei | 乌梅 | Japanese apricot | Prunus mume |
| H1090 | Gao Ben | 藁本 | Chinese ligusticum | Ligusticum sinense |
| H1195 | Bai Ma Gu | 白马骨 | all - grass of snow of june. | Herba serissae |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0632 | Xia Ku Cao | 夏枯草 | Common selfheal | Prunella vulgaris |
| H0741 | Yi Zhi Hao | 一枝蒿 | Alpine yarrow herb | Solidago decurrens |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H0681 | Xiong Dan Fen | 熊胆粉 | Bear gall | Conyza blinii |
| H1011 | Bai Chou | 白丑 | Pharbitis seed | Semen pharbitidis |
| H0075 | Jing Mi | 粳米 | Rice | Oryza sativa |
| H1068 | Bai He Liu Jin Gao | 百合流浸膏 | Lily | Lilium brownii |
| H0185 | Luo Shi Teng | 络石藤 | Chinese star jasmine | Trachelospermum jasminoides |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0892 | Chuan Xiong | 川芎 | cnidium officinale | Cnidium officinale |
| H0416 | Shan Shen | 山参 | NA | Panax ginseng |
| H0776 | Zao Ci | 皂刺 | spine of chinese honeylocust | Spina gleditsiae |
| H0514 | Cang Er Cao | 苍耳草 | Cocklebur grass | Xanthium sibiricum |
| H0765 | Chi Dou | 赤豆 | Assuki bean | Vigna angularis |
| H0147 | Lie Dang | 列当 | Skyblue broomrape | Orobanche coerulescens |
| H0891 | Chuan Xin Lian Ye | 穿心莲叶 | Powder of green chiretta leaves | Andrographis herba |
| H0358 | Ren Shen Ye | 人参叶 | Ginseng leaf | Panax ginseng |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0379 | Bian Xu | 萹蓄 | Common knotgrass | Polygonum aviculare |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0757 | Ying Su Ke | 罂粟壳 | Opium poppy pericarp | Papaver somniferum |
| H1099 | Gou Teng | 钩藤 | Sharpleaf gambirplant | Uncaria rhynchophylla |
| H1097 | Gong Ding Xiang | 公丁香 | NA | Syzygium aromaticum |
| H0242 | Bei Sha Shen Liu Jin Gao | 北沙参流浸膏 | Glehnia littoralis | Glehnia littoralis |
| H1152 | Bai Jie Zi | 白芥子 | White mustard seed | Sinapis alba |
| H0890 | Chuan Xin Lian Nong Suo Ye | 穿心莲浓缩液 | Common andrographis | Andrographis paniculata |
| H0938 | Da Suan | 大蒜 | Garlic | Allium sativum |
| H0576 | Tu Mu Xiang | 土木香 | Elecampane inula | Inula helenium |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H1120 | Guang Huo Xiang | 广藿香 | Patchouli | Pogostemon cablin |
| H0085 | Jiu Yu Rou | 酒萸肉 | Asiatic cornelian cherry | Cornus officinalis |
| H1220 | Hua Xiang Shu Guo | 化香树果 | NA | Platycarya strobilacea |
| H0440 | Sheng Di Hong Jing Tian | 圣地红景天 | Integripetal rhodiola | Rhodiola sacra |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H0100 | Juan Bai | 卷柏 | Tamariskoid spikemoss | Selaginella tamariscina |
| H1183 | Hong Dou | 红豆 | Hosie ormosia | Ormosia hosiei |
| H0427 | Shan Zhu Yu | 山茱萸 | Asiatic cornelian cherry | Cornus officinalis |
| H1186 | Hong Gen Cao | 红根草 | Hispid sage | Salvia prionitis |
| H1133 | Gui Jian Yu | 鬼箭羽 | Winged euonymus | Euonymus alatus |
| H1221 | Hua Xiang Shu Guo Xu | 化香树果序 | NA | Platycarya strobilacea |
| H0496 | Shui Ze Lan | 水泽兰 | NA | Lycopus lucidus |
| H0680 | Xiong Dan | 熊胆 | Bear gall | Conyza blinii |
| H0990 | Ding Xiang | 丁香 | Clove tree | Syzygium aromaticum |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H0074 | Jing Jie Tan | 荆芥炭 | NA | Schizonepetae herba |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H0954 | Dan Zhu Ye | 淡竹叶 | Common lophatherum | Lophatherum gracile |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |
| H1055 | Bai Guo Ren | 白果仁 | ginkgo | Ginkgo biloba |
| H0777 | Zao Jia | 皂荚 | Chinese honeylocust | Gleditsia sinensis |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0965 | Deng Zhan Xi Xin | 灯盏细辛 | Shortscape fleabane | Erigeron breviscapus |
| H0817 | Zhi Zhu Xiang | 蜘蛛香 | Jatamans valeriana | Valeriana jatamansii |
| H0065 | Jin Yin Hua Ti Qu Ye | 金银花提取液 | Japanese honeysuckle | Lonicera japonica |
| H0108 | Ku Lian Pi | 苦楝皮 | Chinaberry-tree bark | Melia azedarach |
| H0357 | Ren Shen | 人参 | Ginseng | Panax ginseng |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0275 | Mu Zei | 木贼 | Common scouring rush | Equisetum hiemale |
| H0729 | Ye Ju Hua | 野菊花 | Indian wild chrysanthemum flower | Chrysanthemum indicum |
| H0354 | Ren Dong Teng | 忍冬藤 | Japanese honeysuckle vine | Lonicera japonica |
| H0248 | Mi Ying Su Ke | 蜜罂粟壳 | Opium poppy | Papaver somniferum |
| H0509 | Cang Er | 苍耳 | Siberian cocklebur | Xanthium sibiricum |
| H0871 | Chuan Duan | 川断 | Teasels | Dipsacus asper |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0047 | Jin Gang Teng | 金刚藤 | NA | Gymnema sylvestre |
| H0585 | Tu Yin Chen Hao | 土茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H0779 | Zao Jiao Zhen | 皂角针 | Chinese honeylocust spine | Gleditsia sinensis |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0084 | Jiu Li Xiang | 九里香 | Common jasminorange | Murraya paniculata |
| H1188 | Hong Hua | 红花 | Safflower | Carthamus tinctorius |
| H0612 | Cao Shan Hu Jin Gao | 草珊瑚浸膏 | NA | Sarcandra glabra |
| H0241 | Mi Hou Tao | 猕猴桃 | Yangtao actinidia | Actinidia chinensis |
| H0750 | Yin Xing Ye | 银杏叶 | Folium ginkgo | Ginkgo biloba |
| H0448 | Bo He You | 薄荷油 | Mint | Mentha haplocalyx |
| H0671 | Xie Cao | 缬草 | Common valeriana | Valeriana officinalis |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H1100 | Gu Jing Cao | 谷精草 | Pipewart | Eriocaulon buergerianum |
| H0839 | Zhua Di Hu | 抓地虎 | Valerian | Valeriana officinalis |
| H0005 | Huo Xiang Ye | 藿香叶 | Patchouli | Pogostemon cablin |
| H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H1020 | E Bu Shi Cao Nong Suo Ye | 鹅不食草浓缩液 | Small centipeda | Centipeda minima |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0109 | Ku Lian Zi | 苦楝子 | NA | Melia azedarach |
| H0116 | Kuan Ye Xie Cao | 宽叶缬草 | NA | Valeriana officinalis |
| H1010 | Du Huo Xiang | 杜藿香 | Patchouli | Pogostemon cablin |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0649 | Xiang Si Zi | 相思子 | Coralhead plant | Abrus precatorius |
| H0745 | Yin Chen Hao | 茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H0534 | Teng Li Gen | 藤梨根 | NA | Actinidia arguta |
| H0614 | Wu Zhao Long | 五爪龙 | Cairo morningglory | Ipomoea cairica |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H1102 | Gu Sui Bu | 骨碎补 | Fortune’s drynaria rhizome | Drynaria fortunei |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H1201 | Hu Er Cao | 虎耳草 | Creeping rockfoil | Saxifraga stolonifera |
| H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
| H0778 | Zao Jiao Ci | 皂角刺 | spine of chinese honeylocust | Spina gleditsiae |
| H1217 | Bai Mei Hua | 白梅花 | Japanese apricot flower | Prunus mume |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
| H0050 | Jin Gang Tou | 金刚头 | NA | Gymnema sylvestre |
| H0698 | Ya Zao | 牙皂 | Chinese honeylocust abnormal fruit | Gleditsia sinensis |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0746 | Yin Chen Hao Gan Jin Gao | 茵陈蒿干浸膏 | Capillary wormwood | Artemisia capillaris |
| H1240 | Huang Jing Zi | 黄荆子 | NA | Vitex negundo |
| H0423 | Shan Zha Ye | 山楂叶 | NA | Crataegi folium |
| H0648 | Xiang Si Teng | 相思藤 | Coralhead plant vine | Abrus precatorius |
| H0546 | Tian Shan Xue Lian Hua | 天山雪莲花 | NA | Saussurea involucrata |
| H0243 | Mi Kuan Dong Hua | 蜜款冬花 | Common coltsfoot | Tussilago farfara |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H0602 | Wu Mei Rou | 乌梅肉 | Ebony | Prunus mume |
| H0572 | Tu Huo Xiang | 土藿香 | Patchouli | Pogostemon cablin |
| H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H0886 | Chuan Xin Lian | 穿心莲 | Common andrographis | Andrographis paniculata |
| H0889 | Chuan Xin Lian Jin Gao | 穿心莲浸膏 | Common andrographis | Andrographis paniculata |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H0700 | Ya Zhi Cao | 鸭跖草 | Common dayflower | Commelina communis |
| H0894 | Chuan Xu Duan | 川续断 | Himalayan teasel | Dipsacus asperoides |
| H0115 | Kuan Dong Hua | 款冬花 | Common coltsfoot | Tussilago farfara |
| H0697 | Ya Ma Zi | 亚麻子 | Common flax seed | Linum usitatissimum |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H0691 | Xue Lian Hua | 雪莲花 | Snow lotus | Saussurea involucrata |
| H0006 | Bai Qu Cai | 白屈菜 | Greater celandine | Chelidonium majus |
| H1061 | Bai He | 百合 | Lily | Lilium brownii |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H1019 | E Bu Shi Cao | 鹅不食草 | Small centipeda | Centipeda minima |
| H0239 | Bei Sha Shen | 北沙参 | Coastal glehnia | Glehnia littoralis |
Ckey description of the interaction between compound and target