Herb Description
| Herb ID: H0757 | Chinese Character: 罂粟壳 |
| English Name: Opium poppy pericarp | Latin Name: Papaver somniferum |
| Chinese Pin Yin : Ying Su Ke | TCM-ID: TCMH2515 |
| Therapeutic Function in Chinese : 收涩 | Therapeutic Function in English: Astriction |
| Herb Function: Astringe the intestine, relieve diarrhea and alleviate pain, Astringe the lung and relieve cough | |
Related Targets (Total: 143)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T13KGH | Tyrosinase | TYR |
P14679 |
2 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
2 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
2 Reference(s) |
| T66YJ0 | Mu-type opioid receptor | OPRM1 |
P35372 |
12 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
3 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
3 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
1 Reference(s) |
| T44C7S | Gastrin/cholecystokinin type B receptor | CCKBR |
P32239 |
1 Reference(s) |
| T38G6P | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | PDE10A |
Q9Y233 |
2 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
6 Reference(s) |
| T38N54 | Fumarate hydratase, mitochondrial | FH |
P07954 |
1 Reference(s) |
| T18VDI | Apoptosis-inducing factor 1, mitochondrial | AIFM1 |
O95831 |
1 Reference(s) |
| T62KUY | Endonuclease G, mitochondrial | ENDOG |
Q14249 |
1 Reference(s) |
| T90ADC | BH3-interacting domain death agonist | BID |
P55957 |
1 Reference(s) |
| T31MUM | 5,6-dihydroxyindole-2-carboxylic acid oxidase | TYRP1 |
P17643 |
1 Reference(s) |
| T34I45 | Neuronal acetylcholine receptor subunit alpha-7 | CHRNA7 |
P36544 |
5 Reference(s) |
| T22H7B | Neuronal acetylcholine receptor subunit alpha-4 | CHRNA4 |
P43681 |
1 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
2 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
3 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
2 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
4 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
1 Reference(s) |
| T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
1 Reference(s) |
| T54X6V | Intermediate conductance calcium-activated potassium channel protein 4 | KCNN4 |
O15554 |
1 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
2 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
1 Reference(s) |
| T20VPX | Cyclin-dependent-like kinase 5 | CDK5 |
Q00535 |
1 Reference(s) |
| T47BNM | Solute carrier family 22 member 1 | SLC22A1 |
O15245 |
1 Reference(s) |
| T76TBD | UDP-glucuronosyltransferase 2B4 | UGT2B4 |
P06133 |
1 Reference(s) |
| T92FAW | Dual specificity protein phosphatase 1 | DUSP1 |
P28562 |
2 Reference(s) |
| T02P7Q | Dihydrofolate reductase | DHFR |
P00374 |
1 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
4 Reference(s) |
| T83ENN | Solute carrier family 22 member 3 | SLC22A3 |
O75751 |
1 Reference(s) |
| T43DMF | Kappa-type opioid receptor | OPRK1 |
P41145 |
5 Reference(s) |
| T70U24 | Sigma non-opioid intracellular receptor 1 | SIGMAR1 |
Q99720 |
5 Reference(s) |
| T82S6C | Hexokinase-4 | GCK |
P35557 |
1 Reference(s) |
| T97XM0 | Hexokinase-1 | HK1 |
P19367 |
1 Reference(s) |
| T32UNL | Lens fiber major intrinsic protein | MIP |
P30301 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
2 Reference(s) |
| T73WJH | Calcium/calmodulin-dependent protein kinase kinase 2 | CAMKK2 |
Q96RR4 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
| T85Y6T | Adenylate cyclase type 8 | ADCY8 |
P40145 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
2 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T51WML | Glutamate receptor 1 | GRIA1 |
P42261 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
2 Reference(s) |
| T34DZ7 | Interleukin-2 | IL2 |
P60568 |
3 Reference(s) |
| T00EP2 | Tissue-type plasminogen activator | PLAT |
P00750 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
3 Reference(s) |
| T37VLU | Interferon gamma | IFNG |
P01579 |
2 Reference(s) |
| T23TJV | Tyrosine 3-monooxygenase | TH |
P07101 |
1 Reference(s) |
| T08OEP | Monocyte differentiation antigen CD14 | CD14 |
P08571 |
1 Reference(s) |
| T86CQC | Glutamate receptor ionotropic, NMDA 1 | GRIN1 |
Q05586 |
3 Reference(s) |
| T74SS7 | Glutamate receptor ionotropic, NMDA 2A | GRIN2A |
Q12879 |
1 Reference(s) |
| T27ZM7 | Disks large homolog 4 | DLG4 |
P78352 |
1 Reference(s) |
| T54IMC | Vesicular glutamate transporter 1 | SLC17A7 |
Q9P2U7 |
1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
2 Reference(s) |
| T66A7X | Activity-regulated cytoskeleton-associated protein | ARC |
Q7LC44 |
1 Reference(s) |
| T96N1K | Calcium/calmodulin-dependent protein kinase type IV | CAMK4 |
Q16566 |
1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
2 Reference(s) |
| T19EKF | Cholecystokinin | CCK |
P06307 |
1 Reference(s) |
| T12WTT | Interleukin-5 | IL5 |
P05113 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
3 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
2 Reference(s) |
| T70SFS | Superoxide dismutase [Mn], mitochondrial | SOD2 |
P04179 |
1 Reference(s) |
| T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
1 Reference(s) |
| T02OOS | C-C chemokine receptor type 5 | CCR5 |
P51681 |
2 Reference(s) |
| T88ENR | Beta-arrestin-1 | ARRB1 |
P49407 |
1 Reference(s) |
| T45FPZ | Antizyme inhibitor 2 | AZIN2 |
Q96A70 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
2 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
1 Reference(s) |
| T32JN2 | Beta-glucuronidase | GUSB |
P08236 |
1 Reference(s) |
| T96U07 | Myristoylated alanine-rich C-kinase substrate | MARCKS |
P29966 |
1 Reference(s) |
| T04LY5 | Creatine kinase B-type | CKB |
P12277 |
2 Reference(s) |
| T10WID | Pro-adrenomedullin [Cleaved into: Adrenomedullin | ADM |
P35318 |
1 Reference(s) |
| T22H8P | Carbonic anhydrase 3 | CA3 |
P07451 |
1 Reference(s) |
| T37BP1 | Serine/threonine-protein kinase pim-1 | PIM1 |
P11309 |
1 Reference(s) |
| T25S8M | Phosphatidylethanolamine N-methyltransferase | PEMT |
Q9UBM1 |
1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
2 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
| T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
1 Reference(s) |
| T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
1 Reference(s) |
| T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
3 Reference(s) |
| T93R42 | Dipeptidyl peptidase 1 | CTSC |
P53634 |
1 Reference(s) |
| T95K8Q | Intestinal-type alkaline phosphatase | ALPI |
P09923 |
1 Reference(s) |
| T82I7J | C-C motif chemokine 16 | CCL16 |
O15467 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T17TKM | Melanocortin receptor 4 | MC4R |
P32245 |
1 Reference(s) |
| T05WWN | Corticoliberin | CRH |
P06850 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
2 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
2 Reference(s) |
| T18R9N | Neuroendocrine convertase 1 | PCSK1 |
P29120 |
1 Reference(s) |
| T47UGF | Neuroendocrine convertase 2 | PCSK2 |
P16519 |
1 Reference(s) |
| T55KUF | Guanine nucleotide-binding protein subunit alpha-12 | GNA12 |
Q03113 |
1 Reference(s) |
| T56G7O | Acyl-CoA-binding protein | DBI |
P07108 |
2 Reference(s) |
| T45TMC | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | PLCG1 |
P19174 |
1 Reference(s) |
| T02HVB | Midkine | MDK |
P21741 |
1 Reference(s) |
| T51UV4 | Trans-acting T-cell-specific transcription factor GATA-3 | GATA3 |
P23771 |
1 Reference(s) |
| T92LK2 | Tumor necrosis factor ligand superfamily member 10 | TNFSF10 |
P50591 |
1 Reference(s) |
| T35KD8 | C-C chemokine receptor type 3 | CCR3 |
P51677 |
1 Reference(s) |
| T54YW8 | C-C motif chemokine 4 | CCL4 |
P13236 |
1 Reference(s) |
| T04WTG | Mitogen-activated protein kinase 10 | MAPK10 |
P53779 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
2 Reference(s) |
| T46K2X | Heat shock 70 kDa protein 4 | HSPA4 |
P34932 |
1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
1 Reference(s) |
| T79UQC | C-X-C motif chemokine 10 | CXCL10 |
P02778 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
| T46PRA | Excitatory amino acid transporter 3 | SLC1A1 |
P43005 |
1 Reference(s) |
| T31VDH | Myeloid differentiation primary response protein MyD88 | MYD88 |
Q99836 |
1 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
1 Reference(s) |
| T17E49 | Cannabinoid receptor 1 | CNR1 |
P21554 |
1 Reference(s) |
| T17CNB | Thioredoxin | TXN |
P10599 |
1 Reference(s) |
| T19HN8 | UDP-glucuronosyltransferase 2B7 | UGT2B7 |
P16662 |
1 Reference(s) |
| T22V6A | Eukaryotic translation initiation factor 2-alpha kinase 3 | EIF2AK3 |
Q9NZJ5 |
1 Reference(s) |
| T47YVM | Serine/threonine-protein kinase Sgk1 | SGK1 |
O00141 |
1 Reference(s) |
| T90LA2 | Sphingomyelin phosphodiesterase | SMPD1 |
P17405 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
5 Reference(s) |
| T16KVU | Tumor necrosis factor receptor superfamily member 1A | TNFRSF1A |
P19438 |
1 Reference(s) |
| T42D4V | Histone deacetylase 1 | HDAC1 |
Q13547 |
1 Reference(s) |
| T00T9M | Thrombospondin-1 | THBS1 |
P07996 |
1 Reference(s) |
| T73QZ2 | Methylcytosine dioxygenase TET2 | TET2 |
Q6N021 |
1 Reference(s) |
| T76AZQ | Histidine decarboxylase | HDC |
P19113 |
1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
1 Reference(s) |
| T93W1J | Vascular endothelial growth factor C | VEGFC |
P49767 |
1 Reference(s) |
| T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
1 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
1 Reference(s) |
| T33KFW | Matrilysin | MMP7 |
P09237 |
1 Reference(s) |
| T28Z4N | Hepatitis A virus cellular receptor 1 | HAVCR1 |
Q96D42 |
1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
1 Reference(s) |
| T42O1D | Delta-type opioid receptor | OPRD1 |
P41143 |
1 Reference(s) |
Related Compounds (Total: 21)
C0291
Name: Paraben
C1258
Name: Coumaric Acid
C0226
Name: Morphine
C0290
Name: Papaverine
C0086
Name: Fumaric Acid
key description of the interaction between compound and target