Target Description
| Type | Detail |
|---|---|
| Target ID | T31MUM |
| Protein Name | 5,6-dihydroxyindole-2-carboxylic acid oxidase |
| Uniprot ID |
P17643 |
| Protein Name Alias | DHICA oxidase; EC 1.14.18.-; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1 |
| Gene ID |
7306 |
| Gene Symbol | TYRP1 |
| Gene Alias | CAS2; TYRP; TYRRP |
| TTD | T00938: Clinical Trial target |
| Pfam | PF00264 |
| GO |
0030318:melanocyte differentiation
0010008:endosome membrane 0043438:acetoacetic acid metabolic process 0032438:melanosome organization 0048023:positive regulation of melanin biosynthetic process 0046872:metal ion binding 0004503:monophenol monooxygenase activity 0016021:integral component of membrane 0005737:cytoplasm 0042438:melanin biosynthetic process 0030669:clathrin-coated endocytic vesicle membrane 0042803:protein homodimerization activity 0033162:melanosome membrane 0042470:melanosome 0097708:intracellular vesicle |
| PDB | 5M8P ; 5M8M ; 5M8S ; 5M8O ; 5M8N ; 5M8Q ; 5M8L ; 5M8R ; 5M8T |
| Drugbank | NA |
| KEGG | hsa:7306 |
Related Herbs (Total: 205)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0763 | Yu Mi Xu | 玉米须 | Maize style | Zea mays |
| H0785 | Ze Xi Huang Lian | 择细黄连 | Coptis deltoidea | Coptis chinensis |
| H0196 | Ma Dou Ling | 马兜铃 | Slender dutchmanspipe | Aristolochia debilis |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0757 | Ying Su Ke | 罂粟壳 | Opium poppy pericarp | Papaver somniferum |
| H1089 | Gang Ren Zi | 岗稔子 | rose myrtle | Rhodomyrtus tomentosa |
| H0029 | Jiang Huang Lian | 姜黄连 | Coptis deltoidea | Coptis chinensis |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H0206 | Ma Wei Song Gen | 马尾松根 | NA | Pinus massoniana |
| H0590 | Wei Ling | 威灵 | Chinese clematis | Clematis chinensis |
| H0207 | Ma Wei Song Shu Gen | 马尾松树根 | NA | Pinus massoniana |
| H0712 | Yan Jing She | 眼镜蛇 | NA | Naja naja |
| H1202 | Hu Huang Lian | 胡黄连 | Picrorhiza | Picrorhiza kurrooa |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0399 | Sha Ren Ye | 砂仁叶 | NA | Amomum villosum |
| H0745 | Yin Chen Hao | 茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0248 | Mi Ying Su Ke | 蜜罂粟壳 | Opium poppy | Papaver somniferum |
| H0699 | Chang Pu | 菖蒲 | rhizome of grassleaf sweetflag. | Acorus calamus |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0429 | Shao Yao | 芍药 | Red peony root | Paeonia obovata |
| H0874 | Chuan Long Shu Yu | 穿龙薯蓣 | Nippon yam | Dioscorea nipponica |
| H0938 | Da Suan | 大蒜 | Garlic | Allium sativum |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H0524 | Tan Xiang | 檀香 | Sandalwood | Santalum album |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H0005 | Huo Xiang Ye | 藿香叶 | Patchouli | Pogostemon cablin |
| H1133 | Gui Jian Yu | 鬼箭羽 | Winged euonymus | Euonymus alatus |
| H1052 | Fu Fang Teng | 扶芳藤 | Forture euonymus | Euonymus fortunei |
| H1094 | Ge Gen | 葛根 | Lobed kudzuvine root | Pueraria lobata |
| H1080 | Gan Ge | 干葛 | Lobed kudzuvine root | Pueraria lobata |
| H0153 | Ling Zhi(1) | 灵芝 | Lucid ganoderma | Ganoderma lucidum |
| H0539 | Tian Hua Fen | 天花粉 | Mongolian snakegourd root | Trichosanthes kirilowii |
| H1111 | Gua Lou Gen | 栝楼根 | NA | Trichosanthes kirilowii |
| H1120 | Guang Huo Xiang | 广藿香 | Patchouli | Pogostemon cablin |
| H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |
| H0841 | Chou Wu Tong | 臭梧桐 | Harlequin glorybower | Clerodendrum trichotomum |
| H0109 | Ku Lian Zi | 苦楝子 | NA | Melia azedarach |
| H0773 | Chi Fu Ling | 赤茯苓 | light red indian bread | Wolfiporia cocos |
| H0506 | Song Xiang | 松香 | Colophony | Pinus massoniana |
| H0317 | Pu Huang Jin Gao | 蒲黄浸膏 | Typha angustifolia | Typha angustata |
| H1240 | Huang Jing Zi | 黄荆子 | NA | Vitex negundo |
| H0551 | Cang Zhu | 苍术 | Swordlike atractylodes | Atractylodes lancea |
| H0458 | Shi Hu | 石斛 | Dendrobium | Herba dendrobii |
| H1105 | Gua Lou Pi | 瓜蒌皮 | NA | Trichosanthes kirilowii |
| H1010 | Du Huo Xiang | 杜藿香 | Patchouli | Pogostemon cablin |
| H0921 | Ba Jiao Lian | 八角莲 | Dysosma | Dysosma versipellis |
| H1019 | E Bu Shi Cao | 鹅不食草 | Small centipeda | Centipeda minima |
| H1219 | Hua Sheng Mi | 花生米 | NA | Arachis hypogaea |
| H1235 | Huang Hao | 黄蒿 | Virg ate wormwood | Artemisia scoparia |
| H0015 | Ji Xing Zi | 急性子 | Garden balsam seed | Impatiens balsamina |
| H0566 | Cao Cong Rong | 草苁蓉 | Russian boschniakia | Boschniakia rossica |
| H0825 | Zhu Fu Shen | 朱茯神 | Indian bread with pine | Poria cocos |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H1051 | Bai Guo | 白果 | Ginkgo nut | Ginkgo biloba |
| H0872 | Chuan Huang Lian | 川黄连 | rhizome of chinese goldthread | Coptis chinensis |
| H0108 | Ku Lian Pi | 苦楝皮 | Chinaberry-tree bark | Melia azedarach |
| H0542 | Tian Ma | 天麻 | Tall gastrodia | Gastrodia elata |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0082 | Jiu Huang Lian | 酒黄连 | Coptis deltoidea | Coptis chinensis |
| H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
| H0613 | Wu Yue Ai | 五月艾 | Artemisia | Artemisia princeps |
| H0682 | Xiong Huang Lian | 雄黄连 | Coptis deltoidea | Coptis chinensis |
| H0154 | Ai Ye You | 艾叶油 | Argy wormwood leaf | Artemisia argyi |
| H0722 | Yang Nai Nai Ye | 羊奶奶叶 | NA | Elaeagnus pungens |
| H1140 | Guo Gang Long | 过岗龙 | NA | Entada phaseoloides |
| H1060 | Fo Shou | 佛手 | Fleshfingered citron | Citrus medica var. sarcodactylis |
| H0103 | Ai Ye | 艾叶 | Argy wormwood leaf | Artemisia argyi |
| H1095 | Ge Gen Gan Jin Gao | 葛根干浸膏 | Lobed kudzuvine root | Pueraria lobata |
| H0403 | Shan Cang Zi | 山苍子 | NA | Litsea cubeba |
| H1104 | Gua Lou | 瓜蒌 | NA | Trichosanthes kirilowii |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H1046 | Feng Xian Tou Gu Cao | 凤仙透骨草 | Spotted snapweed | Impatiens balsamina |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H0042 | Bai Tou Weng | 白头翁 | Chinese pulsatilla | Pulsatilla chinensis |
| H0316 | Pu Huang | 蒲黄 | Typha angustifolia | Typha angustata |
| H0345 | Qing Guo Tan | 青果炭 | white olive | Canarium album |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H1100 | Gu Jing Cao | 谷精草 | Pipewart | Eriocaulon buergerianum |
| H1208 | Hu Ma Ren | 胡麻仁 | white seed of oriental sesame | Sesamum indicum |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H0877 | Chuan Niu Xi | 川牛膝 | Mediinal cyathula | Cyathula officinalis |
| H0418 | Shan Yin Chen | 山茵陈 | Capillary wormwood | Artemisia capillaris |
| H0727 | Ye Gan Cao | 野甘草 | Sweet broomwort | Scoparia dulcis |
| H1241 | Huang Lian | 黄连 | Coptis deltoidea | Coptis chinensis |
| H0612 | Cao Shan Hu Jin Gao | 草珊瑚浸膏 | NA | Sarcandra glabra |
| H0939 | Da Xue Teng | 大血藤 | Sargentgloryvine | Sargentodoxa cuneata |
| H0004 | Huo Xiang | 藿香 | Patchouli | Pogostemon cablin |
| H1218 | Hua Sheng | 花生 | NA | Arachis hypogaea |
| H0747 | An Xi Xiang | 安息香 | Sumatra snowbel | Styrax benzoin |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0100 | Juan Bai | 卷柏 | Tamariskoid spikemoss | Selaginella tamariscina |
| H1053 | Fu Ling | 茯苓 | Indian bread | Wolfiporia cocos |
| H0113 | Ban Bian Lian | 半边莲 | Chinese lobelia | Lobelia chinensis |
| H0256 | Ming Dang Shen | 明党参 | Medicinal changium | Changium smyrnioides |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0172 | Lu Gen | 芦根 | Common reed rhizome | Phragmites communis |
| H0754 | Ying Bu Bo | 鹰不泊 | Avicenna’s pricklyash | Zanthoxylum avicennae |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0065 | Jin Yin Hua Ti Qu Ye | 金银花提取液 | Japanese honeysuckle | Lonicera japonica |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H1188 | Hong Hua | 红花 | Safflower | Carthamus tinctorius |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0995 | Dong Chong Xia Cao | 冬虫夏草 | Aweto | Cordyceps sinensis |
| H1247 | Huang Qi | 黄芪 | Membranous milkvetch | Astragalus membranaceus |
| H0920 | Da Ban Bian Lian | 大半边莲 | Asian lobelia | Lobelia chinensis |
| H0007 | Huo Xue Teng | 活血藤 | NA | Sargentodoxa cuneata |
| H0756 | Ying Su | 罂粟 | Opium poppy | Papaver somniferum |
| H0526 | Tang Gu Te Wu Tou | 唐古特乌头 | NA | Aconitum tanguticum |
| H0760 | Yu Huang Lian | 萸黄连 | Coptis deltoidea | Coptis chinensis |
| H0715 | Che Qian Zi | 车前子 | seed of asiatic pantain | Plantago asiatica |
| H1106 | Gua Lou Ren | 瓜蒌仁 | NA | Trichosanthes kirilowii |
| H0784 | Chi Shao | 赤芍 | Red peony root | Paeonia obovata |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H1082 | Gan Lan | 橄榄 | Cabbage | Canarium album |
| H1112 | Gua Lou Ren(1) | 栝楼仁 | NA | Trichosanthes kirilowii |
| H0572 | Tu Huo Xiang | 土藿香 | Patchouli | Pogostemon cablin |
| H1045 | Feng Xian Hua | 凤仙花 | Spotted snapweed | Impatiens balsamina |
| H1090 | Gao Ben | 藁本 | Chinese ligusticum | Ligusticum sinense |
| H0354 | Ren Dong Teng | 忍冬藤 | Japanese honeysuckle vine | Lonicera japonica |
| H0064 | Jin Yin Hua | 金银花 | Japanese honeysuckle | Lonicera japonica |
| H0775 | Yun Zhi | 云芝 | Coriolus versicolor | Polysaccharidum versicolor |
| H0510 | Su He Xiang | 苏合香 | Oriental sweetgum resin | Liquidambar orientalis |
| H1108 | Gua Lou Shi | 栝蒌实 | NA | Trichosanthes kirilowii |
| H0897 | Chuan Lian | 川楝 | Chinaberry | Melia azedarach |
| H0536 | Tian Di Ding | 甜地丁 | Manyflower gueldenstaedtid herb | Viola philippica |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H0755 | Ying Shan Hong | 映山红 | Korean rhododendron | Rhododendron mucronulatum |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0075 | Jing Mi | 粳米 | Rice | Oryza sativa |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H0963 | Dao Kou Cao | 倒扣草 | NA | Achyranthes aspera |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0750 | Yin Xing Ye | 银杏叶 | Folium ginkgo | Ginkgo biloba |
| H0217 | Man Jing Zi | 蔓荆子 | Threeleaf chastetree fruit | Vitex trifolia |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0216 | Man Jing Ye | 蔓荆叶 | Threeleaf chastetree leaf | Vitex trifolia |
| H0592 | Wei Ling Xian | 威灵仙 | Chinese clematis | Clematis chinensis |
| H0279 | Nan Gua | 南瓜 | Cushaw | Cucurbita moschata |
| H0446 | Sheng Jiang | 生姜 | Fresh common ginger | Zingiber officinale |
| H0577 | Tu Niu Xi | 土牛膝 | Common achyranthes | Achyranthes aspera |
| H0041 | Jie Gu Mu | 接骨木 | Elder* equivalent plant: sambucus nigra | Sambucus williamsii |
| H0695 | Ya Dan Zi | 鸦胆子 | Java brucea | Brucea javanica |
| H0239 | Bei Sha Shen | 北沙参 | Coastal glehnia | Glehnia littoralis |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H1220 | Hua Xiang Shu Guo | 化香树果 | NA | Platycarya strobilacea |
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H1250 | Huang Qi Ti Qu Ye | 黄芪提取液 | Membranous milkvetch | Astragalus membranaceus |
| H0846 | Chou Wu Tong Ye | 臭梧桐叶 | Harlequin glorybower | Clerodendrum trichotomum |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0507 | Song Zhi | 松脂 | Rosin | Pinus massoniana |
| H0344 | Qing Guo | 青果 | Olive | Canarium album |
| H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
| H0242 | Bei Sha Shen Liu Jin Gao | 北沙参流浸膏 | Glehnia littoralis | Glehnia littoralis |
| H0255 | Mao Zhao Cao | 猫爪草 | Root of catclaw buttercup | Ranunculus ternatus |
| H1096 | Ge Hua | 葛花 | flower bud of lobed kudzuvine | Pueraria lobata |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0729 | Ye Ju Hua | 野菊花 | Indian wild chrysanthemum flower | Chrysanthemum indicum |
| H0377 | San Ling | 三棱 | Common burreed | Sparganium stoloniferum |
| H1181 | Hei Zhi Ma | 黑芝麻 | Oriental sesame | Sesamum indicum |
| H1210 | Hu Tui Zi Ye | 胡颓子叶 | NA | Elaeagnus pungens |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H1243 | Huang Lian Xu | 黄连须 | Coptis deltoidea | Coptis chinensis |
| H1200 | Bai Mao Gen | 白茅根 | Lalang grass rhizome | Imperata cylindrica |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H0233 | Mao Liang Mian Zhen | 毛两面针 | NA | Zanthoxylum nitidum |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H1141 | Guo Gang Long Jin Gao | 过岗龙浸膏 | NA | Entada phaseoloides |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0730 | Ye Ma Zhui | 野马追 | NA | Eupatorium lindleyanum |
| H0183 | Luo Hua Sheng Zhi Ye | 落花生枝叶 | Peanut branch-leaf | Arachis hypogaea |
| H0915 | Cong Bai | 葱白 | Fistular onion | Allium fistulosum |
| H0410 | Shan Jiang Zi | 山姜子 | NA | Litsea cubeba |
| H0585 | Tu Yin Chen Hao | 土茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H1221 | Hua Xiang Shu Guo Xu | 化香树果序 | NA | Platycarya strobilacea |
| H1005 | Dou Chi Jiang | 豆豉姜 | Folium litseae cubebae | Litsea cubeba |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H1110 | Gua Lou Zi | 瓜蒌子 | mongolian snakegourd seed | Trichosanthes kirilowii maxim |
| H0457 | Shi Er | 石耳 | Rock-Ears | Umbilicaria esculenta |
| H1020 | E Bu Shi Cao Nong Suo Ye | 鹅不食草浓缩液 | Small centipeda | Centipeda minima |
| H0398 | Sha Ren | 砂仁 | Villous amomum | Amomum villosum |
| H1055 | Bai Guo Ren | 白果仁 | ginkgo | Ginkgo biloba |
| H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
| H0900 | Chun Gen Pi | 椿根皮 | Ailanthus bark, tree of heaven bark | Ailanthus altissima |
| H0324 | Qian Jin Ba | 千斤拔 | root of philippine flemingia | Radix moghaniae philippinensis |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0083 | Jiu Jie Cha | 九节茶 | Glabrous sarcandra | Sarcandra glabra |
| H0746 | Yin Chen Hao Gan Jin Gao | 茵陈蒿干浸膏 | Capillary wormwood | Artemisia capillaris |
| H0548 | Tian Ye Ju | 甜叶菊 | Rebaud eupatorium* | Eupatorium rebaudianum |
| H1249 | Huang Qi Jin Gao | 黄芪浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0346 | Qing Mu Xiang | 青木香 | Slender dutchmanspipe root | Aristolochia debilis |
| H1107 | Gua Lou Ren Shuang | 瓜蒌仁霜 | NA | Trichosanthes kirilowii |
| H0762 | Yu Li Ren | 郁李仁 | NA | Prunus japonica |
| H1248 | Huang Qi Gan Jin Gao | 黄芪干浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H1242 | Huang Lian Gan Jin Gao | 黄连干浸膏 | Coptis deltoidea | Coptis chinensis |
| H0528 | Tao Jin Niang Gen | 桃金娘根 | Downy rosemyrtle root | Rhodomyrtus tomentosa |
| H1207 | Hu Ma | 胡麻 | white seed of oriental sesame | Sesamum indicum |
| H0152 | Ling Zhi Jin Gao | 灵芝浸膏 | NA | Ganoderma lucidum |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |