HIT-result

Target id	Protein Name	Gene Symbol	Uniprot ID	No.of Literature Evidence
T13KGH	Tyrosinase	TYR	P14679	1 Reference(s)
T31MUM	5,6-dihydroxyindole-2-carboxylic acid oxidase	TYRP1	P17643	1 Reference(s)
T88AJI	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	1 Reference(s)
T23P74	Caspase-9	CASP9	P55211	3 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	7 Reference(s)
T50SJ8	5'-AMP-activated protein kinase catalytic subunit alpha-2	PRKAA2	P54646	1 Reference(s)
T79KQO	NF-kappa-B inhibitor alpha	NFKBIA	P25963	1 Reference(s)
T81I4T	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	Q13131	1 Reference(s)
T74QXI	Serine/threonine-protein kinase mTOR	MTOR	P42345	1 Reference(s)
T12PIB	Lysosomal alpha-glucosidase	GAA	P10253	2 Reference(s)
T83YZD	Acetylcholinesterase	ACHE	P22303	1 Reference(s)
T91T8I	Glucose-6-phosphatase catalytic subunit 1	G6PC1	P35575	1 Reference(s)
T58J2Y	Peroxisome proliferator-activated receptor gamma	PPARG	P37231	2 Reference(s)
T25Y64	Cholinesterase	BCHE	P06276	1 Reference(s)
T98RXH	Focal adhesion kinase 1	PTK2	Q05397	1 Reference(s)
T53RK9	T-cell surface glycoprotein CD4	CD4	P01730	1 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	2 Reference(s)
T80OPZ	NADPH oxidase 4	NOX4	Q9NPH5	2 Reference(s)
T20TB8	NADPH oxidase 1	NOX1	Q9Y5S8	24 Reference(s)
T20E5P	Cytochrome b-245 heavy chain	CYBB	P04839	5 Reference(s)
T20HY9	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial	DECR1	Q16698	1 Reference(s)
T00H7Q	Neutrophil cytosol factor 1	NCF1	P14598	2 Reference(s)
T68R23	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PCK2	Q16822	1 Reference(s)
T25NSJ	Mitogen-activated protein kinase 3	MAPK3	P27361	1 Reference(s)
T79WXA	Mitogen-activated protein kinase 1	MAPK1	P28482	2 Reference(s)
T03CZ8	Catechol O-methyltransferase	COMT	P21964	2 Reference(s)
T64UH1	Nitric oxide synthase, endothelial	NOS3	P29474	3 Reference(s)
T22H8P	Carbonic anhydrase 3	CA3	P07451	1 Reference(s)
T38T1U	Caspase-8	CASP8	Q14790	1 Reference(s)
T71K92	Apoptosis regulator Bcl-2	BCL2	P10415	4 Reference(s)
T80TUC	Apoptosis regulator BAX	BAX	Q07812	2 Reference(s)
T53AOE	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide	TGFB1	P01137	1 Reference(s)
T29MD1	Mitogen-activated protein kinase 8	MAPK8	P45983	1 Reference(s)
T92Q77	Type I iodothyronine deiodinase	DIO1	P49895	1 Reference(s)
T99EYH	Lipoprotein lipase	LPL	P06858	1 Reference(s)
T16A2X	Catalase	CAT	P04040	1 Reference(s)
T99W15	Pancreatic triacylglycerol lipase	PNLIP	P16233	1 Reference(s)
T56TXY	Polyunsaturated fatty acid 5-lipoxygenase	ALOX5	P09917	1 Reference(s)
T24LXT	G2/mitotic-specific cyclin-B1	CCNB1	P14635	1 Reference(s)
T75H3W	Cyclin-dependent kinase 2	CDK2	P24941	1 Reference(s)
T86UXL	Cyclin-A2	CCNA2	P20248	1 Reference(s)
T30D9G	Superoxide dismutase [Cu-Zn]	SOD1	P00441	2 Reference(s)
T70SFS	Superoxide dismutase [Mn], mitochondrial	SOD2	P04179	1 Reference(s)
T09GFP	Maltase-glucoamylase, intestinal [Includes: Maltase	MGAM	O43451	1 Reference(s)
T28PHS	Angiotensin-converting enzyme	ACE	P12821	1 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	1 Reference(s)
T26KIE	Transcription factor AP-1	JUN	P05412	1 Reference(s)
T97FEF	Broad substrate specificity ATP-binding cassette transporter ABCG2	ABCG2	Q9UNQ0	2 Reference(s)
T02P7Q	Dihydrofolate reductase	DHFR	P00374	1 Reference(s)
T14ENF	Microtubule-associated protein 2	MAP2	P11137	1 Reference(s)
T78ZF2	Protein kinase C alpha type	PRKCA	P17252	1 Reference(s)
T93VFT	Endothelin-1	EDN1	P05305	1 Reference(s)
T42EAZ	Vascular endothelial growth factor A	VEGFA	P15692	1 Reference(s)
T74LFK	Neurogenic locus notch homolog protein 1	NOTCH1	P46531	1 Reference(s)
T62ERY	Interleukin-1 receptor-associated kinase 4	IRAK4	Q9NWZ3	1 Reference(s)
T22NX4	Toll-like receptor 2	TLR2	O60603	1 Reference(s)
T76AZQ	Histidine decarboxylase	HDC	P19113	1 Reference(s)
T06RMZ	Nuclear factor NF-kappa-B p105 subunit	NFKB1	P19838	1 Reference(s)
T00EP2	Tissue-type plasminogen activator	PLAT	P00750	1 Reference(s)
T84P70	Urokinase-type plasminogen activator	PLAU	P00749	1 Reference(s)
T33OPP	Interleukin-6	IL6	P05231	2 Reference(s)
T27U96	Granulocyte-macrophage colony-stimulating factor	CSF2	P04141	1 Reference(s)
T35QZO	Cytochrome c	CYCS	P99999	1 Reference(s)
T53QS9	Glutamate--cysteine ligase catalytic subunit	GCLC	P48506	1 Reference(s)
T83QQX	Cytochrome b-245 light chain	CYBA	P13498	1 Reference(s)
T91OUC	Mucin-5AC	MUC5AC	P98088	1 Reference(s)
T80U0C	Glutathione synthetase	GSS	P48637	1 Reference(s)
T34HYH	Interleukin-1 alpha	IL1A	P01583	1 Reference(s)
T84VZG	Ryanodine receptor 1	RYR1	P21817	1 Reference(s)
T49XOZ	Krueppel-like factor 7	KLF7	O75840	1 Reference(s)
T74JJN	Fatty acid synthase	FASN	P49327	1 Reference(s)
T49TDM	Matrix metalloproteinase-9	MMP9	P14780	1 Reference(s)
T80GUN	72 kDa type IV collagenase	MMP2	P08253	1 Reference(s)

Herb ID: H0939	Chinese Character: 大血藤
English Name: Sargentgloryvine	Latin Name: Sargentodoxa cuneata
Chinese Pin Yin : Da Xue Teng	TCM-ID: TCMH385
Therapeutic Function in Chinese : 清热	Therapeutic Function in English: Heat clearence
Herb Function: Remove toxic heat, promote blood circulation, and relieve rheumatic conditions

Herb Description

Related Targets (Total: 73)

Related Compounds (Total: 10)