Target Description
| Type | Detail |
|---|---|
| Target ID | T53QS9 |
| Protein Name | Glutamate--cysteine ligase catalytic subunit |
| Uniprot ID |
P48506 |
| Protein Name Alias | EC 6.3.2.2; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase |
| Gene ID |
2729 |
| Gene Symbol | GCLC |
| Gene Alias | GLCL; GLCLC |
| TTD | NA |
| Pfam | PF03074 |
| GO |
0006750:glutathione biosynthetic process
0006534:cysteine metabolic process 0005829:cytosol 0045454:cell redox homeostasis 0043531:ADP binding 0005524:ATP binding 0004357:glutamate-cysteine ligase activity 0045892:negative regulation of transcription, DNA-templated 0009725:response to hormone 0006536:glutamate metabolic process 0043066:negative regulation of apoptotic process 0097746:blood vessel diameter maintenance 0017109:glutamate-cysteine ligase complex 0006979:response to oxidative stress 0016595:glutamate binding 0009408:response to heat 0000287:magnesium ion binding |
| PDB | NA |
| Drugbank | DB00142 ; DB14002 ; DB00151 ; DB00163 ; DB14001 |
| KEGG | hsa:2729 |
Related Compounds (Total: 4)
Related Herbs (Total: 78)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0332 | Qiao Mai | 荞麦 | Common buckwheat | Fagopyrum esculentum |
| H0626 | Xi Nan Huang Qin | 西南黄芩 | Yunnan skullcap | Scutellaria amoena |
| H0446 | Sheng Jiang | 生姜 | Fresh common ginger | Zingiber officinale |
| H0357 | Ren Shen | 人参 | Ginseng | Panax ginseng |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0655 | Xiao Bai Bu | 小百部 | Officinal asparagus | Asparagus officinalis |
| H0585 | Tu Yin Chen Hao | 土茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0126 | Lai Fu Zi | 莱菔子 | Garden radish seed | Raphanus sativus |
| H0967 | Di Er Cao | 地耳草 | Japanese stJohn’swort | Hypericum japonicum |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H0430 | She Chuang Zi | 蛇床子 | Common cnidium | Cnidium monnieri |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0958 | Dang Shen | 党参 | Pilose asiabell | Codonopsis pilosula |
| H0746 | Yin Chen Hao Gan Jin Gao | 茵陈蒿干浸膏 | Capillary wormwood | Artemisia capillaris |
| H0541 | Cang Qie Gen | 藏茄根 | Tibetan eggplant root | Anisodus tanguticus |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0559 | Tong Cao | 通草 | puth of ricepaperplant | Tetrapanax papyriferus |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0693 | Xue Xie | 血蝎 | Dragon's blood | Daemonorops draco |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0418 | Shan Yin Chen | 山茵陈 | Capillary wormwood | Artemisia capillaris |
| H0466 | Cai Fu Zi | 菜菔子 | Semen raphani | Raphanus sativus |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1187 | Hong Guan Yao | 红管药 | NA | Aster ageratoides |
| H0368 | Rou Gui Zi | 肉桂子 | Cassiabarktree | Cinnamomum cassia |
| H0350 | Qu Mai | 瞿麦 | Lilac pink | Dianthus superbus |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0413 | Shan Lang Dang | 山莨菪 | NA | Anisodus tanguticus |
| H0433 | She Ma Zi | 蛇麻子 | Common cnidium fruit | Cnidium monnieri |
| H0226 | Man Yue Mei | 蔓越莓 | Cranberry | Vaccinium oxycoccos |
| H1202 | Hu Huang Lian | 胡黄连 | Picrorhiza | Picrorhiza kurrooa |
| H1166 | He Shou Wu | 何首乌 | Tuber fleeceflower | Polygonum multiflorum |
| H0253 | Mian Hua Gen | 棉花根 | Levant cotton root | Gossypium herbaceum |
| H0049 | Bai Wei | 白薇 | Blackend swallowwort | Cynanchum atratum |
| H0939 | Da Xue Teng | 大血藤 | Sargentgloryvine | Sargentodoxa cuneata |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1201 | Hu Er Cao | 虎耳草 | Creeping rockfoil | Saxifraga stolonifera |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0432 | She Gan | 射干 | Blackberrylily | Belamcanda chinensis |
| H0323 | Qian Hu | 前胡 | Common hogfennel | Angelica decursiva |
| H0366 | Rou Gui | 肉桂 | Cassiabarktree | Cinnamomum cassia |
| H0427 | Shan Zhu Yu | 山茱萸 | Asiatic cornelian cherry | Cornus officinalis |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0765 | Chi Dou | 赤豆 | Assuki bean | Vigna angularis |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H0325 | Qian Jin Zi | 千金子 | Caper euphorbia seed | Euphorbia lathyris |
| H0085 | Jiu Yu Rou | 酒萸肉 | Asiatic cornelian cherry | Cornus officinalis |
| H0745 | Yin Chen Hao | 茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0995 | Dong Chong Xia Cao | 冬虫夏草 | Aweto | Cordyceps sinensis |
| H0179 | Lu Xian Cao | 鹿衔草 | Chinese pyrola | Pyrola calliantha |
| H0358 | Ren Shen Ye | 人参叶 | Ginseng leaf | Panax ginseng |
| H0960 | Dang Shen Qing Gao | 党参清膏 | Root of hairy asiabell | Codonopsis pilosula |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1114 | Guan Gui | 官桂 | Cassiabarktree | Cinnamomum cassia |
| H0883 | Chuan She Gan | 川射干 | Blackberrylily | Belamcanda chinensis |
| H0454 | Shi Diao Bai | 石刁柏 | Curinary asparagus | Asparagus officinalis |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0348 | Qing Wa Qi | 青蛙七 | Wall iris | Iris tectorum |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
| H1139 | Gui Zhi | 桂枝 | Cassiabarktree twig | Cinnamomum cassia |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0617 | Qian Cao Teng | 茜草藤 | NA | Rubia cordifolia |
| H1117 | Guan Zhong | 贯众 | Male fern rhizome | Dryopteris crassirhizoma |
| H0125 | Lai Fu | 莱菔 | Garden radish | Raphanus sativus |
| H0007 | Huo Xue Teng | 活血藤 | NA | Sargentodoxa cuneata |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0416 | Shan Shen | 山参 | NA | Panax ginseng |
| H0434 | She Pu Tao | 蛇葡萄 | Ampelopsis | Ampelopsis brevipedunculata |