Compound Description
| ID: C1259 | Common name: Coumarin |
| IUPAC: chromen-2-one | CAS: CAS:91-64-5 |
| Chembl ID: CHEMBL6466 | Pubchem ID: CID:323 |
| Formula: C9H6O2 | TCM-ID: TCMC949 |
| Smiles: C1=CC=C2C(=C1)C=CC(=O)O2 | |
| Alias:
Coumarin;
1,2-Benzopyrone; 2-Chromenone; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, δ-lactone; 2H-Benzopyran-2-one; 2H-Chromen-2-one; 5,6-Benzo-2-pyrone; Benzo-α-pyrone; Coumarinic anhydride; Lympedim; NSC 8774; Rattex; Tonka bean camphor; cis-o-Coumarinic acid lactone; o-Hydroxycinnamic acid lactone |
Structure:
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Related Targets (Total: 14)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
A | 2 Reference(s) |
| T56MD7 | Glutathione hydrolase 5 proenzyme | GGT5 |
P36269 |
B | 1 Reference(s) |
| T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
B | 1 Reference(s) |
| T48J1U | Aldo-keto reductase family 1 member C1 | AKR1C1 |
Q04828 |
B | 1 Reference(s) |
| T46AQJ | Glutathione S-transferase P | GSTP1 |
P09211 |
B | 1 Reference(s) |
| T53QS9 | Glutamate--cysteine ligase catalytic subunit | GCLC |
P48506 |
B | 1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
B | 1 Reference(s) |
| T12BGL | Cytochrome P450 2A6 | CYP2A6 |
P11509 |
B | 1 Reference(s) |
| T62F1Y | Glutathione S-transferase A2 | GSTA2 |
P09210 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
C | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
C | 1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 41)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1201 | Hu Er Cao | 虎耳草 | Creeping rockfoil | Saxifraga stolonifera |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0332 | Qiao Mai | 荞麦 | Common buckwheat | Fagopyrum esculentum |
| H0655 | Xiao Bai Bu | 小百部 | Officinal asparagus | Asparagus officinalis |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
| H0433 | She Ma Zi | 蛇麻子 | Common cnidium fruit | Cnidium monnieri |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0745 | Yin Chen Hao | 茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0368 | Rou Gui Zi | 肉桂子 | Cassiabarktree | Cinnamomum cassia |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0430 | She Chuang Zi | 蛇床子 | Common cnidium | Cnidium monnieri |
| H0366 | Rou Gui | 肉桂 | Cassiabarktree | Cinnamomum cassia |
| H0559 | Tong Cao | 通草 | puth of ricepaperplant | Tetrapanax papyriferus |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0350 | Qu Mai | 瞿麦 | Lilac pink | Dianthus superbus |
| H1114 | Guan Gui | 官桂 | Cassiabarktree | Cinnamomum cassia |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0585 | Tu Yin Chen Hao | 土茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H0325 | Qian Jin Zi | 千金子 | Caper euphorbia seed | Euphorbia lathyris |
| H1187 | Hong Guan Yao | 红管药 | NA | Aster ageratoides |
| H0454 | Shi Diao Bai | 石刁柏 | Curinary asparagus | Asparagus officinalis |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0427 | Shan Zhu Yu | 山茱萸 | Asiatic cornelian cherry | Cornus officinalis |
| H0967 | Di Er Cao | 地耳草 | Japanese stJohn’swort | Hypericum japonicum |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0085 | Jiu Yu Rou | 酒萸肉 | Asiatic cornelian cherry | Cornus officinalis |
| H0541 | Cang Qie Gen | 藏茄根 | Tibetan eggplant root | Anisodus tanguticus |
| H1139 | Gui Zhi | 桂枝 | Cassiabarktree twig | Cinnamomum cassia |
| H0413 | Shan Lang Dang | 山莨菪 | NA | Anisodus tanguticus |
| H0746 | Yin Chen Hao Gan Jin Gao | 茵陈蒿干浸膏 | Capillary wormwood | Artemisia capillaris |
| H0323 | Qian Hu | 前胡 | Common hogfennel | Angelica decursiva |
| H0179 | Lu Xian Cao | 鹿衔草 | Chinese pyrola | Pyrola calliantha |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H0418 | Shan Yin Chen | 山茵陈 | Capillary wormwood | Artemisia capillaris |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
Ckey description of the interaction between compound and target