Target Description

Type Detail
Target ID T12BGL
Protein Name Cytochrome P450 2A6
Uniprot ID P11509
Protein Name Alias EC 1.14.13.-;  1,4-cineole 2-exo-monooxygenase;  CYPIIA6;  Coumarin 7-hydroxylase;  Cytochrome P450 IIA3;  Cytochrome P450(I)
Gene ID 1548
Gene Symbol CYP2A6
Gene Alias CYP2A3
TTD T06455: Successful target
Pfam PF00067
GO
0009804:coumarin metabolic process

0042738:exogenous drug catabolic process

0005506:iron ion binding

0006082:organic acid metabolic process

0006805:xenobiotic metabolic process

0008202:steroid metabolic process

0043231:intracellular membrane-bounded organelle

0019899:enzyme binding

0005789:endoplasmic reticulum membrane

0019373:epoxygenase P450 pathway

0016712:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

0008395:steroid hydroxylase activity

0017144:drug metabolic process

0046226:coumarin catabolic process

0008389:coumarin 7-hydroxylase activity

0008392:arachidonic acid epoxygenase activity

0020037:heme binding

0005737:cytoplasm

0005881:cytoplasmic microtubule

PDB 1Z10 ; 3T3R ; 4RUI ; 3EBS ; 2FDY ; 2FDW ; 4EJJ ; 1Z11 ; 2FDU ; 2FDV ; 3T3Q
Drugbank DB00951 ; DB00604 ; DB00356 ; DB01085 ; DB00544 ; DB00182 ; DB01236 ; DB04977 ; DB01544 ; DB00316 ; DB09274 ; DB00675 ; DB00752 ; DB07609 ; DB01039 ; DB01181 ; DB01043 ; DB00412 ; DB01234 ; DB01110 ; DB03783 ; DB00238 ; DB00184 ; DB00553 ; DB07623 ; DB00312 ; DB06470 ; DB00281 ; DB00741 ; DB04665 ; DB14631 ; DB07617 ; DB01174 ; DB06119 ; DB00396 ; DB00916 ; DB00471 ; DB06712 ; DB00690 ; DB01028 ; DB01274 ; DB01435 ; DB09068 ; DB00983 ; DB00257 ; DB00972 ; DB00170 ; DB04871 ; DB00635 ; DB00568 ; DB00717 ; DB01006 ; DB06292 ; DB00959 ; DB00755 ; DB09256 ; DB01222 ; DB01118 ; DB00531 ; DB05676 ; DB00313 ; DB01045 ; DB14649 ; DB11586 ; DB00495 ; DB01011 ; DB12245 ; DB01026 ; DB00763 ; DB07621 ; DB00363 ; DB00252 ; DB06448 ; DB00216 ; DB01213 ; DB01037 ; DB04841 ; DB00443 ; DB01159 ; DB01115 ; DB09327 ; DB06739
KEGG hsa:1548

Related Compounds  (Total: 5)

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C0101
Name: Genistein
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C0181
Name: Levomenthol
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C0214
Name: Methoxsalen
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C0463
Name: Tryptamine
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C1259
Name: Coumarin


Related Herbs  (Total: 110)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0332 Qiao Mai荞麦 Common buckwheatFagopyrum esculentum
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H0947 Dan Mian Zhen单面针 NAZanthoxylum echinocarpum
H0338 Qing Ban Xia清半夏 Ternate pinelliaPinellia ternata
H0312 Po Gu Zhi破故纸 fruit of malaytea scurfpeaFructus psoraleae corylifoliae
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0655 Xiao Bai Bu小百部 Officinal asparagusAsparagus officinalis
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0026 Jiang Soybean pasteGlycine max
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0430 She Chuang Zi蛇床子 Common cnidiumCnidium monnieri
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0541 Cang Qie Gen藏茄根 Tibetan eggplant rootAnisodus tanguticus
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1225 Huai Mi槐米 NASophora japonica
H0387 San Ya Ku三桠苦 Common rueRuta graveolens
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H0559 Tong Cao通草 puth of ricepaperplantTetrapanax papyriferus
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H1227 Huai Zhi槐枝 NASophora japonica
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1187 Hong Guan Yao红管药 NAAster ageratoides
H0625 Ce Bai Tan侧柏炭 Oriental arbor-vitaePlatycladus orientalis
H0368 Rou Gui Zi肉桂子 CassiabarktreeCinnamomum cassia
H0350 Qu Mai瞿麦 Lilac pinkDianthus superbus
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0413 Shan Lang Dang山莨菪 NAAnisodus tanguticus
H0433 She Ma Zi蛇麻子 Common cnidium fruitCnidium monnieri
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1201 Hu Er Cao虎耳草 Creeping rockfoilSaxifraga stolonifera
H1030 Fang Feng防风 Divaricate saposhnikoviaSaposhnikovia divaricata
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0763 Yu Mi Xu玉米须 Maize styleZea mays
H0323 Qian Hu前胡 Common hogfennelAngelica decursiva
H0282 Nan Sha Shen南沙参 Fourleaf ladybell rootRadix adenophorae
H0366 Rou Gui肉桂 CassiabarktreeCinnamomum cassia
H0862 Zuan Gu Feng钻骨风 NAPiper hancei
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0398 Sha Ren砂仁 Villous amomumAmomum villosum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0865 Chuan Bi Feng穿壁风 hance pepper stem and leafPiper hancei
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H1007 Dou You豆油 Soybean oilGlycine max
H0456 Bu Gu Zhi补骨脂 Malaytea scurfpeaPsoralea corylifolia
H0399 Sha Ren Ye砂仁叶 NAAmomum villosum
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H0013 Ji Shi Teng鸡矢藤 FevervinePaederia scandens
H0325 Qian Jin Zi千金子 Caper euphorbia seedEuphorbia lathyris
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0179 Lu Xian Cao鹿衔草 Chinese pyrolaPyrola calliantha
H0439 Sheng Ban Xia生半夏 Ternate pinelliaPinellia ternata
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H0159 Ban Xia Qu半夏曲 Pinellia tuber leavenPinellia ternata
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H1114 Guan Gui官桂 CassiabarktreeCinnamomum cassia
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0454 Shi Diao Bai石刁柏 Curinary asparagusAsparagus officinalis
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0273 Mu Tong木通 Fiveleaf akebiaAkebia quinata
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0774 Yun Xiang Jin Gao芸香浸膏 RutaRuta graveolens
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H1139 Gui Zhi桂枝 Cassiabarktree twigCinnamomum cassia
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0215 Mai Ya麦芽 Barley germinating fruitHordeum vulgare
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis