Herb Description
| Herb ID: H1094 | Chinese Character: 葛根 |
| English Name: Lobed kudzuvine root | Latin Name: Pueraria lobata |
| Chinese Pin Yin : Ge Gen | TCM-ID: TCMH677 |
| Therapeutic Function in Chinese : 解表 | Therapeutic Function in English: For relieving exterior syndrome |
| Herb Function: Relieve fever, promote the production of body fluid,facilitate eruption, and arrest diarrhea | |
Related Targets (Total: 183)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
10 Reference(s) |
| T22JG3 | Fibroblast growth factor receptor 2 | FGFR2 |
P21802 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
11 Reference(s) |
| T53KY7 | Cystic fibrosis transmembrane conductance regulator | CFTR |
P13569 |
2 Reference(s) |
| T69XEM | Tyrosine-protein kinase SYK | SYK |
P43405 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
2 Reference(s) |
| T27LA6 | DNA | DNMT1 |
P26358 |
1 Reference(s) |
| T25UYT | Dual specificity mitogen-activated protein kinase kinase 4 | MAP2K4 |
P45985 |
1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
3 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
3 Reference(s) |
| T70NYW | Fibroblast growth factor receptor 4 | FGFR4 |
P22455 |
1 Reference(s) |
| T03VS9 | Protein-tyrosine kinase 2-beta | PTK2B |
Q14289 |
3 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
4 Reference(s) |
| T12BGL | Cytochrome P450 2A6 | CYP2A6 |
P11509 |
1 Reference(s) |
| T24VJT | GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase | H6PD |
O95479 |
1 Reference(s) |
| T93YV8 | Tumor necrosis factor receptor superfamily member 11B | TNFRSF11B |
O00300 |
3 Reference(s) |
| T07TRP | Short transient receptor potential channel 5 | TRPC5 |
Q9UL62 |
1 Reference(s) |
| T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
1 Reference(s) |
| T15RPU | Kinesin-like protein KIF20A | KIF20A |
O95235 |
1 Reference(s) |
| T68DAN | Histone deacetylase 9 | HDAC9 |
Q9UKV0 |
1 Reference(s) |
| T49CBW | Class E basic helix-loop-helix protein 40 | BHLHE40 |
O14503 |
1 Reference(s) |
| T40DIM | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 |
P28845 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
7 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
2 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
2 Reference(s) |
| T28ULC | NA | MIR22 |
NA |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
3 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
1 Reference(s) |
| T16MRU | NACHT, LRR and PYD domains-containing protein 3 | NLRP3 |
Q96P20 |
2 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
4 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
2 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
3 Reference(s) |
| T65JYL | C-X-C motif chemokine 2 | CXCL2 |
P19875 |
1 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
4 Reference(s) |
| T32OC4 | Aldehyde dehydrogenase, mitochondrial | ALDH2 |
P05091 |
3 Reference(s) |
| T91W8B | All-trans-retinol dehydrogenase [NAD(+)] ADH4 | ADH4 |
P08319 |
1 Reference(s) |
| T44WZO | Alcohol dehydrogenase 1C | ADH1C |
P00326 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
2 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
2 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
2 Reference(s) |
| T22MME | Quinone oxidoreductase | CRYZ |
Q08257 |
1 Reference(s) |
| T53G91 | Nischarin | NISCH |
Q9Y2I1 |
1 Reference(s) |
| T49WXY | DNA nucleotidylexotransferase | DNTT |
P04053 |
1 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
1 Reference(s) |
| T61OY3 | UDP-glucuronosyltransferase 1A1 | UGT1A1 |
P22309 |
1 Reference(s) |
| T19JEU | Beta-galactosidase | GLB1 |
P16278 |
1 Reference(s) |
| T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
2 Reference(s) |
| T42XY2 | Insulin-like growth factor 1 receptor | IGF1R |
P08069 |
2 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
4 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
6 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
4 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
3 Reference(s) |
| T78VUO | RAF proto-oncogene serine/threonine-protein kinase | RAF1 |
P04049 |
2 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
6 Reference(s) |
| T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
4 Reference(s) |
| T20NCI | Serine-protein kinase ATM | ATM |
Q13315 |
1 Reference(s) |
| T28EY5 | Serine/threonine-protein kinase Chk2 | CHEK2 |
O96017 |
2 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
2 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
2 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
2 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
4 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
3 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
3 Reference(s) |
| T86UXL | Cyclin-A2 | CCNA2 |
P20248 |
1 Reference(s) |
| T68NCI | Aldo-keto reductase family 1 member B1 | AKR1B1 |
P15121 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
4 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
3 Reference(s) |
| T77PFO | Histone deacetylase 6 | HDAC6 |
Q9UBN7 |
1 Reference(s) |
| T26UZV | Dual specificity mitogen-activated protein kinase kinase 5 | MAP2K5 |
Q13163 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
4 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
4 Reference(s) |
| T44S1A | Apolipoprotein A-I | APOA1 |
P02647 |
1 Reference(s) |
| T54VQA | Cyclin-dependent kinase inhibitor 2A | CDKN2A |
P42771 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
2 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
2 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
2 Reference(s) |
| T79A7K | Protein PML | PML |
P29590 |
1 Reference(s) |
| T19Z2N | Nuclear receptor corepressor 1 | NCOR1 |
O75376 |
1 Reference(s) |
| T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
1 Reference(s) |
| T31P1D | Metalloproteinase inhibitor 1 | TIMP1 |
P01033 |
2 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
| T39M81 | DNA-(apurinic or apyrimidinic site) endonuclease | APEX1 |
P27695 |
1 Reference(s) |
| T05WU9 | Serine/threonine-protein phosphatase 2A activator | PTPA |
Q15257 |
1 Reference(s) |
| T98QOA | DNA-dependent protein kinase catalytic subunit | PRKDC |
P78527 |
1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
2 Reference(s) |
| T79TJS | Caveolin-3 | CAV3 |
P56539 |
1 Reference(s) |
| T17E95 | Protein kinase C gamma type | PRKCG |
P05129 |
1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
| T04AHN | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 | HSD3B2 |
P26439 |
1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
1 Reference(s) |
| T23K1O | Calmodulin | CALM3;CALML2;CAM3;CAMC;CAMIII |
P62158 |
1 Reference(s) |
| T09TS5 | Gamma-aminobutyric acid type B receptor subunit 1 | GABBR1 |
Q9UBS5 |
1 Reference(s) |
| T74ETU | Steroid 21-hydroxylase | CYP21A2 |
P08686 |
1 Reference(s) |
| T50WUM | Leucine--tRNA ligase, cytoplasmic | LARS1 |
Q9P2J5 |
1 Reference(s) |
| T30V3R | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | HSD3B1 |
P14060 |
2 Reference(s) |
| T29GH0 | Trefoil factor 1 | TFF1 |
P04155 |
3 Reference(s) |
| T98JPP | Carnitine O-palmitoyltransferase 1, liver isoform | CPT1A |
P50416 |
1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
| T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
3 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
1 Reference(s) |
| T90XMB | Ubiquitin carboxyl-terminal hydrolase 5 | USP5 |
P45974 |
1 Reference(s) |
| T40G6B | Prostaglandin reductase 1 | PTGR1 |
Q14914 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
1 Reference(s) |
| T38N69 | Lymphokine-activated killer T-cell-originated protein kinase | PBK |
Q96KB5 |
1 Reference(s) |
| T06PVX | E3 ubiquitin-protein ligase Mdm2 | MDM2 |
Q00987 |
1 Reference(s) |
| T42K6K | M-phase inducer phosphatase 3 | CDC25C |
P30307 |
1 Reference(s) |
| T89VFL | Alpha-crystallin B chain | CRYAB |
P02511 |
1 Reference(s) |
| T04A2Q | Serine/threonine-protein kinase PLK1 | PLK1 |
P53350 |
1 Reference(s) |
| T82S6C | Hexokinase-4 | GCK |
P35557 |
1 Reference(s) |
| T00F43 | Mediator of DNA damage checkpoint protein 1 | MDC1 |
Q14676 |
1 Reference(s) |
| T21YK3 | Cell division cycle protein 20 homolog | CDC20 |
Q12834 |
1 Reference(s) |
| T75I26 | Mitotic checkpoint serine/threonine-protein kinase BUB1 | BUB1 |
O43683 |
1 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
2 Reference(s) |
| T13I7C | Transforming growth factor beta-2 proprotein | TGFB2 |
P61812 |
1 Reference(s) |
| T04WT7 | Fibronectin | FN1 |
P02751 |
1 Reference(s) |
| T03G09 | Tumor necrosis factor ligand superfamily member 11 | TNFSF11 |
O14788 |
2 Reference(s) |
| T34N64 | NA | MIR29B1 |
NA |
1 Reference(s) |
| T30NJL | Electrogenic sodium bicarbonate cotransporter 1 | SLC4A4 |
Q9Y6R1 |
1 Reference(s) |
| T33JS5 | CCN family member 2 | CCN2 |
P29279 |
2 Reference(s) |
| T88MR0 | Solute carrier family 26 member 6 | SLC26A6 |
Q9BXS9 |
1 Reference(s) |
| T91MKC | Runt-related transcription factor 2 | RUNX2 |
Q13950 |
1 Reference(s) |
| T31SX8 | Bone morphogenetic protein 2 | BMP2 |
P12643 |
1 Reference(s) |
| T17X6I | DNA fragmentation factor subunit alpha | DFFA |
O00273 |
1 Reference(s) |
| T16S8T | Baculoviral IAP repeat-containing protein 7 | BIRC7 |
Q96CA5 |
1 Reference(s) |
| T46AQJ | Glutathione S-transferase P | GSTP1 |
P09211 |
1 Reference(s) |
| T49A2A | Sodium/hydrogen exchanger 1 | SLC9A1 |
P19634 |
1 Reference(s) |
| T25SPW | Sodium/hydrogen exchanger 2 | SLC9A2 |
Q9UBY0 |
1 Reference(s) |
| T09HVO | Sodium/hydrogen exchanger 3 | SLC9A3 |
P48764 |
1 Reference(s) |
| T33BF9 | DNA | DNMT3B |
Q9UBC3 |
1 Reference(s) |
| T76B0A | Gap junction alpha-1 protein | GJA1 |
P17302 |
1 Reference(s) |
| T74V1Z | Dual specificity mitogen-activated protein kinase kinase 7 | MAP2K7 |
O14733 |
1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
1 Reference(s) |
| T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
1 Reference(s) |
| T24LWC | Sodium-dependent dopamine transporter | SLC6A3 |
Q01959 |
1 Reference(s) |
| T35QZO | Cytochrome c | CYCS |
P99999 |
2 Reference(s) |
| T89SY7 | Zinc finger and BTB domain-containing protein 16 | ZBTB16 |
Q05516 |
1 Reference(s) |
| T92FAW | Dual specificity protein phosphatase 1 | DUSP1 |
P28562 |
1 Reference(s) |
| T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
2 Reference(s) |
| T51WML | Glutamate receptor 1 | GRIA1 |
P42261 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
1 Reference(s) |
| T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
| T13QI6 | Aldo-keto reductase family 1 member A1 | AKR1A1 |
P14550 |
1 Reference(s) |
| T33OSQ | Sterol regulatory element-binding protein 1 | SREBF1 |
P36956 |
1 Reference(s) |
| T71GZE | UDP-glucuronosyltransferase 2B28 | UGT2B28 |
Q9BY64 |
1 Reference(s) |
| T07NZK | Low affinity immunoglobulin epsilon Fc receptor | FCER2 |
P06734 |
1 Reference(s) |
| T11GHO | Transforming protein RhoA | RHOA |
P61586 |
1 Reference(s) |
| T34AYH | Solute carrier family 52, riboflavin transporter, member 1 | SLC52A1 |
Q9NWF4 |
1 Reference(s) |
| T36I66 | Metallothionein-2 | MT2A |
P02795 |
1 Reference(s) |
| T90ZS8 | Endothelin-converting enzyme 1 | ECE1 |
P42892 |
1 Reference(s) |
| T16IWB | Growth arrest and DNA damage-inducible protein GADD45 alpha | GADD45A |
P24522 |
1 Reference(s) |
| T29CYD | BRCA1-associated RING domain protein 1 | BARD1 |
Q99728 |
1 Reference(s) |
| T41SFE | Histone acetyltransferase p300 | EP300 |
Q09472 |
1 Reference(s) |
| T57R3V | Proliferation marker protein Ki-67 | MKI67 |
P46013 |
1 Reference(s) |
| T82I76 | Ubiquitin carboxyl-terminal hydrolase BAP1 | BAP1 |
Q92560 |
1 Reference(s) |
| T82S9G | DNA repair protein RAD51 homolog 1 | RAD51 |
Q06609 |
1 Reference(s) |
| T53QOD | ATP synthase subunit beta, mitochondrial | ATP5F1B |
P06576 |
1 Reference(s) |
| T63SUZ | NADH-ubiquinone oxidoreductase chain 6 | MT-ND6 |
P03923 |
1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
1 Reference(s) |
| T46HRF | Growth hormone receptor | GHR |
P10912 |
1 Reference(s) |
| T35FQV | Microsomal triglyceride transfer protein large subunit | MTTP |
P55157 |
1 Reference(s) |
| T70SFS | Superoxide dismutase [Mn], mitochondrial | SOD2 |
P04179 |
1 Reference(s) |
| T28B0B | Monocarboxylate transporter 8 | SLC16A2 |
P36021 |
1 Reference(s) |
| T53GFX | Arginase-1 | ARG1 |
P05089 |
1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
| T31MUM | 5,6-dihydroxyindole-2-carboxylic acid oxidase | TYRP1 |
P17643 |
1 Reference(s) |
| T82G5G | L-dopachrome tautomerase | DCT |
P40126 |
1 Reference(s) |
| T89A2U | Hsp90 co-chaperone Cdc37 | CDC37 |
Q16543 |
1 Reference(s) |
| T91AIW | Receptor-type tyrosine-protein kinase FLT3 | FLT3 |
P36888 |
1 Reference(s) |
| T95K8Q | Intestinal-type alkaline phosphatase | ALPI |
P09923 |
1 Reference(s) |
Related Compounds (Total: 9)
C0083
Name: Formononetin
C0101
Name: Genistein
C0337
Name: Puerarin
C1279
Name: Daidzin
C1278
Name: Daidzein
key description of the interaction between compound and target