HIT-result

Type	Detail
Target ID	T20NCI
Protein Name	Serine-protein kinase ATM
Uniprot ID	Q13315
Protein Name Alias	EC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutated
Gene ID	472
Gene Symbol	ATM
Gene Alias	NA
TTD	T97196: Clinical Trial target
Pfam	PF02259 ; PF00454 ; PF02260 ; PF11640
GO	0006974:cellular response to DNA damage stimulus 0007131:reciprocal meiotic recombination 1904262:negative regulation of TORC1 signaling 1905843:regulation of cellular response to gamma radiation 0000425:pexophagy 0007143:female meiotic nuclear division 0051402:neuron apoptotic process 1901796:regulation of signal transduction by p53 class mediator 0007420:brain development 0071044:histone mRNA catabolic process 0030889:negative regulation of B cell proliferation 0097695:establishment of protein-containing complex localization to telomere 1904884:positive regulation of telomerase catalytic core complex assembly 0046777:protein autophosphorylation 0001756:somitogenesis 0090399:replicative senescence 0048538:thymus development 0000724:double-strand break repair via homologous recombination 0006260:DNA replication 0042159:lipoprotein catabolic process 0000723:telomere maintenance 0016303:1-phosphatidylinositol-3-kinase activity 0002331:pre-B cell allelic exclusion 0047485:protein N-terminus binding 0004674:protein serine/threonine kinase activity 0071300:cellular response to retinoic acid 0010212:response to ionizing radiation 0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 0005524:ATP binding 0001666:response to hypoxia 0071480:cellular response to gamma radiation 0106311:protein threonine kinase activity 1990391:DNA repair complex 0042802:identical protein binding 0048599:oocyte development 0071481:cellular response to X-ray 0001541:ovarian follicle development 0007094:mitotic spindle assembly checkpoint 0005782:peroxisomal matrix 0004677:DNA-dependent protein kinase activity 0036289:peptidyl-serine autophosphorylation 1900034:regulation of cellular response to heat 0071500:cellular response to nitrosative stress 0006975:DNA damage induced protein phosphorylation 0033129:positive regulation of histone phosphorylation 0005730:nucleolus 0007507:heart development 0008630:intrinsic apoptotic signaling pathway in response to DNA damage 0000077:DNA damage checkpoint 0042981:regulation of apoptotic process 0007050:cell cycle arrest 0043065:positive regulation of apoptotic process 0035264:multicellular organism growth 0000729:DNA double-strand break processing 0097694:establishment of RNA localization to telomere 0005737:cytoplasm 1904354:negative regulation of telomere capping 0008340:determination of adult lifespan 0005654:nucleoplasm 0003677:DNA binding 0072434:signal transduction involved in mitotic G2 DNA damage checkpoint 0043525:positive regulation of neuron apoptotic process 0045944:positive regulation of transcription by RNA polymerase II 0032210:regulation of telomere maintenance via telomerase 0006302:double-strand break repair 0005634:nucleus 0045141:meiotic telomere clustering 0010628:positive regulation of gene expression 0007165:signal transduction 0010506:regulation of autophagy 1903978:regulation of microglial cell activation 0007140:male meiotic nuclear division 0005819:spindle 0032212:positive regulation of telomere maintenance via telomerase 0006468:protein phosphorylation 0006303:double-strand break repair via nonhomologous end joining 0045785:positive regulation of cell adhesion 1903626:positive regulation of DNA catabolic process 0009791:post-embryonic development 0018105:peptidyl-serine phosphorylation 0033151:V(D)J recombination 0005829:cytosol 0044877:protein-containing complex binding 0016572:histone phosphorylation 0043517:positive regulation of DNA damage response, signal transduction by p53 class mediator 0030335:positive regulation of cell migration 0106310:protein serine kinase activity 1904358:positive regulation of telomere maintenance via telomere lengthening 0043231:intracellular membrane-bounded organelle 0031410:cytoplasmic vesicle
PDB	6K9K ; 6HKA ; 5NP1 ; 5NP0 ; 6K9L
Drugbank	DB00201
KEGG	hsa:472

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Name: Genistein

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Name: Acetylcysteine

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Name: vitamin c

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Name: Caffeine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0341	Qing Feng Teng	青风藤	Orientvine	Sinomenium acutum
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0087	Ju Gu Ye	枸骨叶	FOLIUM iLICIS cORNUTAE	Ilex cornuta
H1007	Dou You	豆油	Soybean oil	Glycine max
H1033	Fang Ji	防己	Fourstamen stephania	Stephania tetrandra
H0615	Wu Zhi Mao Tao	五指毛桃	five-finger fig root	Ficus simplicissima
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0026	Jiang	姜	Soybean paste	Glycine max
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1212	Hu Ye Gan Jin Gao	槲叶干浸膏	NA	Quercus dentata
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1225	Huai Mi	槐米	NA	Sophora japonica
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H0603	Wu Tong Ye Jin Gao	梧桐叶浸膏	Parasol trees	Firmiana simplex
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 58)