Herb Description
| Herb ID: H0087 | Chinese Character: 枸骨叶 |
| English Name: FOLIUM iLICIS cORNUTAE | Latin Name: Ilex cornuta |
| Chinese Pin Yin : Ju Gu Ye | TCM-ID: TCMH1177 |
| Therapeutic Function in Chinese : NA | Therapeutic Function in English: NA |
| Herb Function: NA | |
Related Targets (Total: 133)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T35LKG | Adenosine receptor A1 | ADORA1 |
P30542 |
1 Reference(s) |
| T77M4W | Adenosine receptor A2a | ADORA2A |
P29274 |
3 Reference(s) |
| T20NCI | Serine-protein kinase ATM | ATM |
Q13315 |
2 Reference(s) |
| T74RBE | Inositol 1,4,5-trisphosphate receptor type 1 | ITPR1 |
Q14643 |
2 Reference(s) |
| T84VZG | Ryanodine receptor 1 | RYR1 |
P21817 |
11 Reference(s) |
| T19CTK | Serine/threonine-protein kinase ATR | ATR |
Q13535 |
3 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T20RA0 | Adenosine deaminase | ADA |
P00813 |
1 Reference(s) |
| T67OMA | Ryanodine receptor 2 | RYR2 |
Q92736 |
1 Reference(s) |
| T45LZI | Calcium release-activated calcium channel protein 1 | ORAI1 |
Q96D31 |
1 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
1 Reference(s) |
| T90ZKN | Cathepsin B | CTSB |
P07858 |
1 Reference(s) |
| T70OGQ | Sodium/potassium-transporting ATPase subunit alpha-1 | ATP1A1 |
P05023 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
2 Reference(s) |
| T73EVE | Cyclic AMP-dependent transcription factor ATF-2 | ATF2 |
P15336 |
1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
1 Reference(s) |
| T34FQX | Protein kinase C zeta type | PRKCZ |
Q05513 |
1 Reference(s) |
| T74QOR | Tyrosine-protein kinase JAK3 | JAK3 |
P52333 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
2 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
1 Reference(s) |
| T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
1 Reference(s) |
| T32KN9 | Alpha-amylase 1A | AMY1A |
P0DUB6 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
3 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
2 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
1 Reference(s) |
| T43XD8 | Carbonic anhydrase 2 | CA2 |
P00918 |
1 Reference(s) |
| T16MRU | NACHT, LRR and PYD domains-containing protein 3 | NLRP3 |
Q96P20 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
2 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
1 Reference(s) |
| T49UAP | Ras-specific guanine nucleotide-releasing factor 1 | RASGRF1 |
Q13972 |
1 Reference(s) |
| T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
1 Reference(s) |
| T33JS5 | CCN family member 2 | CCN2 |
P29279 |
1 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
2 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
8 Reference(s) |
| T55EFK | Transcription factor E2F1 | E2F1 |
Q01094 |
1 Reference(s) |
| T45B9P | ATP-sensitive inward rectifier potassium channel 11 | KCNJ11 |
Q14654 |
1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
2 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
3 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
7 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
3 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
3 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
3 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
3 Reference(s) |
| T24D36 | Transcription factor A, mitochondrial | TFAM |
Q00059 |
1 Reference(s) |
| T23XLR | Serine/threonine-protein kinase Nek11 | NEK11 |
Q8NG66 |
1 Reference(s) |
| T84ELW | Myocyte-specific enhancer factor 2A | MEF2A |
Q02078 |
1 Reference(s) |
| T82SDM | Myocyte-specific enhancer factor 2D | MEF2D |
Q14814 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
2 Reference(s) |
| T58CAO | Alpha-synuclein | SNCA |
P37840 |
1 Reference(s) |
| T42PUG | Solute carrier family 2, facilitated glucose transporter member 1 | SLC2A1 |
P11166 |
1 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
| T60DN8 | Bcl-2-like protein 11 | BCL2L11 |
O43521 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
4 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
3 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
4 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
2 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
| T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
2 Reference(s) |
| T88QQE | Fibroblast growth factor 2 | FGF2 |
P09038 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
6 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
4 Reference(s) |
| T39YUJ | Tyrosine-protein phosphatase non-receptor type 6 | PTPN6 |
P29350 |
1 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
2 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T95H9O | Stromelysin-2 | MMP10 |
P09238 |
1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
3 Reference(s) |
| T38OH4 | Caspase-1 | CASP1 |
P29466 |
1 Reference(s) |
| T82G3R | Integrin beta-3 | ITGB3 |
P05106 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
2 Reference(s) |
| T29GRI | Gamma-aminobutyric acid receptor subunit alpha-2 | GABRA2 |
P47869 |
1 Reference(s) |
| T63FRM | Lutropin subunit beta | LHB |
P01229 |
1 Reference(s) |
| T87C4J | Follitropin subunit beta | FSHB |
P01225 |
1 Reference(s) |
| T22Y9W | Neuropeptide S receptor | NPSR1 |
Q6W5P4 |
1 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
| T87N33 | Zinc finger homeobox protein 3 | ZFHX3 |
Q15911 |
1 Reference(s) |
| T23B68 | Immediate early response gene 5 protein | IER5 |
Q5VY09 |
1 Reference(s) |
| T66A7X | Activity-regulated cytoskeleton-associated protein | ARC |
Q7LC44 |
1 Reference(s) |
| T73LNN | Neuropeptide S | NPS |
P0C0P6 |
1 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
3 Reference(s) |
| T48ZIG | D(2) dopamine receptor | DRD2 |
P14416 |
1 Reference(s) |
| T92E71 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11B2 |
P80365 |
1 Reference(s) |
| T40DIM | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 |
P28845 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
2 Reference(s) |
| T08Q1T | Amiloride-sensitive sodium channel subunit alpha | SCNN1A |
P37088 |
1 Reference(s) |
| T36PZ1 | Tryptophan 5-hydroxylase 2 | TPH2 |
Q8IWU9 |
2 Reference(s) |
| T13I7C | Transforming growth factor beta-2 proprotein | TGFB2 |
P61812 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
| T56RMM | DNA | DNMT3A |
Q9Y6K1 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
2 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
2 Reference(s) |
| T28HOM | Leptin | LEP |
P41159 |
1 Reference(s) |
| T41BXR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | SIRT3 |
Q9NTG7 |
1 Reference(s) |
| T27J4O | Gamma-aminobutyric acid receptor subunit rho-1 | GABRR1 |
P24046 |
1 Reference(s) |
| T47G3X | Glucocorticoid receptor | NR3C1 |
P04150 |
1 Reference(s) |
| T78C6N | Cathepsin K | CTSK |
P43235 |
1 Reference(s) |
| T20P3F | Tartrate-resistant acid phosphatase type 5 | ACP5 |
P13686 |
1 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
2 Reference(s) |
| T77FOL | Neuromodulin | GAP43 |
P17677 |
1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
1 Reference(s) |
| T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
| T22IMH | Cyclin-dependent kinase 6 | CDK6 |
Q00534 |
1 Reference(s) |
| T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
| T04UTZ | G1/S-specific cyclin-E1 | CCNE1 |
P24864 |
1 Reference(s) |
| T80OPZ | NADPH oxidase 4 | NOX4 |
Q9NPH5 |
1 Reference(s) |
| T53ES3 | Protein S100-A1 | S100A1 |
P23297 |
1 Reference(s) |
| T04A6O | UDP-glucuronosyltransferase 1A3 | UGT1A3 |
P35503 |
1 Reference(s) |
| T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
1 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
| T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
1 Reference(s) |
| T61OY3 | UDP-glucuronosyltransferase 1A1 | UGT1A1 |
P22309 |
1 Reference(s) |
| T37WQE | Kallikrein-5 | KLK5 |
Q9Y337 |
1 Reference(s) |
| T16DCZ | Twist-related protein 1 | TWIST1 |
Q15672 |
1 Reference(s) |
Related Compounds (Total: 4)
key description of the interaction between compound and target