Target Description

Type Detail
Target ID T90ZKN
Protein Name Cathepsin B
Uniprot ID P07858
Protein Name Alias EC 3.4.22.1;  APP secretase;  APPS;  Cathepsin B1
Gene ID 1508
Gene Symbol CTSB
Gene Alias CPSB
TTD T61746: Preclinical target
Pfam PF08127 ; PF00112
GO
0070062:extracellular exosome

0005615:extracellular space

0005764:lysosome

0042981:regulation of apoptotic process

0050790:regulation of catalytic activity

0030574:collagen catabolic process

0008234:cysteine-type peptidase activity

0005576:extracellular region

0062023:collagen-containing extracellular matrix

0005622:intracellular anatomical structure

0006508:proteolysis

0004197:cysteine-type endopeptidase activity

1904813:ficolin-1-rich granule lumen

0043394:proteoglycan binding

0030855:epithelial cell differentiation

0048471:perinuclear region of cytoplasm

0043312:neutrophil degranulation

0005518:collagen binding

0051603:proteolysis involved in cellular protein catabolic process

0002224:toll-like receptor signaling pathway

0036021:endolysosome lumen

0008233:peptidase activity

0097067:cellular response to thyroid hormone stimulus

0016324:apical plasma membrane

0042470:melanosome

PDB 3K9M ; 1CSB ; 1PBH ; 3AI8 ; 5MBL ; 6AY2 ; 5MBM ; 3CBK ; 2PBH ; 3PBH ; 2IPP ; 1HUC ; 3CBJ ; 1GMY
Drugbank DB07231 ; DB02108 ; DB02685 ; DB07223 ; DB02855 ; DB03588 ; DB04126 ; DB04579 ; DB14962 ; DB07225 ; DB02148 ; DB07219 ; DB07160 ; DB03329 ; DB07224
KEGG hsa:1508

Related Compounds  (Total: 3)

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C0476
Name: Ursolic Acid
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C0867
Name: Alcohol
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C1027
Name: kainic acid


Related Herbs  (Total: 111)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H0357 Ren Shen人参 GinsengPanax ginseng
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0854 Zi Wei Gen Pi紫葳根皮 NACampsis grandiflora
H1109 Bai Hua She She Cao白花蛇舌草 Spreading hedyitisOldenlandia diffusa
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H1049 Feng Xiang Zhi Chou Gao枫香脂稠膏 NALiquidambar formosana
H0177 Lu Lu Tong路路通 Beautiful sweetgumLiquidambar formosana
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0063 Jin Ye Zi金叶子 Yunnan craibiodendronCraibiodendron yunnanese
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H1047 Feng Xiang Ye枫香叶 NALiquidambar formosana
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0902 Chun Pi椿皮 Ailanthus bark, tree of heaven barkAilanthi cortex
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0591 Wei Ling Cai委陵菜 Chinese cinquefoilPotentilla chinensis
H0470 Shi Ye柿叶 Persimmon leafDiospyros kaki
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0747 An Xi Xiang安息香 Sumatra snowbelStyrax benzoin
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0646 Xiang Qing Lan香青兰 DragonheadDracocephalum moldavica
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0493 Shui Yang Mei水杨梅 Japanese avensGeum japonicum
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0701 Yan Bai岩柏 NAJuniperus formosana
H0963 Dao Kou Cao倒扣草 NAAchyranthes aspera
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1186 Hong Gen Cao红根草 Hispid sageSalvia prionitis
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H0715 Che Qian Zi车前子 seed of asiatic pantainPlantago asiatica
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0503 Song Jie松节 Knotty pine wood, pine nodular branchLignum pini nodi
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0453 Shi Di柿蒂 Persimmon persistent calyxDiospyros kaki
H0494 Shui Yang Mei Gen水杨梅根 Japanese avens rootGeum japonicum
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0801 Chong Bai La虫白蜡 Cera chinensis waxEricerus pela
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0169 Lou Lu漏芦 Uniflower swisscentauryRhaponticum uniflorum
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0938 Da Suan大蒜 GarlicAllium sativum
H0577 Tu Niu Xi土牛膝 Common achyranthesAchyranthes aspera
H0894 Chuan Xu Duan川续断 Himalayan teaselDipsacus asperoides
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H1004 Bai Cha白茶 White teaCamellia sinensis
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0622 Xi He Liu西河柳 Chinese tamarisk twigCacumen tamaricis
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0158 Liu Ling Ju六棱菊 NALaggera alata
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0320 Qi Shu Gen漆树根 true lacquertree rootToxicodendron succedaneum
H0416 Shan Shen山参 NAPanax ginseng
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis