HIT-result

ID: C1027	Common name: kainic acid
IUPAC: (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid	CAS: CAS:487-79-6
Chembl ID: CHEMBL275040	Pubchem ID: CID:10255
Formula: C10H15NO4	TCM-ID: TCMC7467
Smiles: CC(=C)C1CNC(C1CC(=O)O)C(=O)O
Alias: 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, [2S-(2alpha,3beta,4beta)]-; 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl- (6CI,7CI,8CI); (-)-Kainic acid; (-)-alpha-Kainic acid; (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic acid; Digenic acid; Digenin; Helminal; Kainic acid; L-alpha-Kainic acid; alpha-Kainic acid	Structure:

Target id	Protein Name	Gene Symbol	Uniprot ID	Target Level	No.of Literature Evidence
T51WML	Glutamate receptor 1	GRIA1	P42261	A	1 Reference(s)
T91SMW	5'-AMP-activated protein kinase subunit gamma-2	PRKAG2	Q9UGJ0	A	1 Reference(s)
T64BTV	Interleukin-1 beta	IL1B	P01584	B	2 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	B	1 Reference(s)
T12T4H	Brain-derived neurotrophic factor	BDNF	P23560	B	2 Reference(s)
T56OUM	14-3-3 protein zeta/delta	YWHAZ	P63104	B	2 Reference(s)
T71K92	Apoptosis regulator Bcl-2	BCL2	P10415	B	2 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	B	2 Reference(s)
T80TUC	Apoptosis regulator BAX	BAX	Q07812	B	3 Reference(s)
T82JWE	Cellular tumor antigen p53	TP53	P04637	B	2 Reference(s)
T61J7T	Mothers against decapentaplegic homolog 2	SMAD2	Q15796	B	1 Reference(s)
T17UP9	C-C motif chemokine 2	CCL2	P13500	B	1 Reference(s)
T65JYL	C-X-C motif chemokine 2	CXCL2	P19875	B	1 Reference(s)
T60DN8	Bcl-2-like protein 11	BCL2L11	O43521	B	1 Reference(s)
T49KTY	Activator of apoptosis harakiri	HRK	O00198	B	1 Reference(s)
T74I49	Bcl-2-like protein 1	BCL2L1	Q07817	B	2 Reference(s)
T15RZ6	Bcl-2-like protein 2	BCL2L2	Q92843	B	1 Reference(s)
T02OOS	C-C chemokine receptor type 5	CCR5	P51681	B	1 Reference(s)
T06PVX	E3 ubiquitin-protein ligase Mdm2	MDM2	Q00987	B	1 Reference(s)
T61GAB	Interleukin-1 receptor antagonist protein	IL1RN	P18510	B	1 Reference(s)
T82R8X	Neuronal cell adhesion molecule	NRCAM	Q92823	B	1 Reference(s)
T97ESI	Apolipoprotein E	APOE	P02649	B	1 Reference(s)
T53YWQ	Pro-neuropeptide Y [Cleaved into: Neuropeptide Y	NPY	P01303	B	1 Reference(s)
T88LSZ	Aromatase	CYP19A1	P11511	B	1 Reference(s)
T44LWL	Transcription factor p65	RELA	Q04206	C	1 Reference(s)
T06N1B	Histamine H1 receptor	HRH1	P35367	C	1 Reference(s)
T90ZKN	Cathepsin B	CTSB	P07858	C	1 Reference(s)
T95EK6	Microtubule-associated proteins 1A/1B light chain 3B	MAP1LC3B	Q9GZQ8	C	1 Reference(s)
T27LTU	C5a anaphylatoxin chemotactic receptor 1	C5AR1	P21730	C	1 Reference(s)
T44SYF	BAG family molecular chaperone regulator 3	BAG3	O95817	C	1 Reference(s)
T76E9B	Sodium/myo-inositol cotransporter 2	SLC5A11	Q8WWX8	C	1 Reference(s)
T05JUS	Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin	PENK	P01210	C	1 Reference(s)
T85D16	Inositol-trisphosphate 3-kinase A	ITPKA	P23677	C	1 Reference(s)
T02O3F	Endothelial lipase	LIPG	Q9Y5X9	C	1 Reference(s)
T10FOS	Neurotrophin-3	NTF3	P20783	C	1 Reference(s)
T67HXL	Glial cell line-derived neurotrophic factor	GDNF	P39905	C	1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Compound Description

Related Targets (Total: 36)

Related Herbs (Total: 0)