HIT-result

Target Description

Type	Detail
Target ID	T51WML
Protein Name	Glutamate receptor 1
Uniprot ID	P42261
Protein Name Alias	GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1
Gene ID	2890
Gene Symbol	GRIA1
Gene Alias	GLUH1; GLUR1
TTD	T33584: Successful target
Pfam	PF10613 ; PF00060 ; PF01094
GO	0006888:endoplasmic reticulum to Golgi vesicle-mediated transport 0008066:glutamate receptor activity 1904315:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 0005789:endoplasmic reticulum membrane 0009986:cell surface 0032591:dendritic spine membrane 0044309:neuron spine 0030425:dendrite 0032281:AMPA glutamate receptor complex 0038023:signaling receptor activity 0007268:chemical synaptic transmission 0043197:dendritic spine 0099061:integral component of postsynaptic density membrane 0055037:recycling endosome 2000310:regulation of NMDA receptor activity 0043025:neuronal cell body 0033116:endoplasmic reticulum-Golgi intermediate compartment membrane 0060076:excitatory synapse 0099544:perisynaptic space 0055038:recycling endosome membrane 0030165:PDZ domain binding 0015276:ligand-gated ion channel activity 0071242:cellular response to ammonium ion 0097060:synaptic membrane 0044308:axonal spine 0031901:early endosome membrane 0005886:plasma membrane 0098978:glutamatergic synapse 0030672:synaptic vesicle membrane 0007616:long-term memory 0004971:AMPA glutamate receptor activity 0014069:postsynaptic density 0031623:receptor internalization 0007165:signal transduction 0048208:COPII vesicle coating 0012507:ER to Golgi transport vesicle membrane 0030666:endocytic vesicle membrane 0099583:neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 0001540:amyloid-beta binding 0060292:long-term synaptic depression
PDB	6X5Q
Drugbank	DB00142 ; DB01236 ; DB01189 ; DB00237 ; DB00753 ; DB04982 ; DB09289 ; DB01028 ; DB05047 ; DB00555 ; DB08883 ; DB06247 ; DB13146 ; DB00898
KEGG	hsa:2890

Type

Detail

Target ID

T51WML

Protein Name

Glutamate receptor 1

Uniprot ID

P42261

Protein Name Alias

GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1

Gene ID

2890

Gene Symbol

GRIA1

Gene Alias

GLUH1; GLUR1

TTD

T33584: Successful target

Pfam

PF10613 ; PF00060 ; PF01094

0006888:endoplasmic reticulum to Golgi vesicle-mediated transport

0008066:glutamate receptor activity

1904315:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

0005789:endoplasmic reticulum membrane

0009986:cell surface

0032591:dendritic spine membrane

0044309:neuron spine

0030425:dendrite

0032281:AMPA glutamate receptor complex

0038023:signaling receptor activity

0007268:chemical synaptic transmission

0043197:dendritic spine

0099061:integral component of postsynaptic density membrane

0055037:recycling endosome

2000310:regulation of NMDA receptor activity

0043025:neuronal cell body

0033116:endoplasmic reticulum-Golgi intermediate compartment membrane

0060076:excitatory synapse

0099544:perisynaptic space

0055038:recycling endosome membrane

0030165:PDZ domain binding

0015276:ligand-gated ion channel activity

0071242:cellular response to ammonium ion

0097060:synaptic membrane

0044308:axonal spine

0031901:early endosome membrane

0005886:plasma membrane

0098978:glutamatergic synapse

0030672:synaptic vesicle membrane

0007616:long-term memory

0004971:AMPA glutamate receptor activity

0014069:postsynaptic density

0031623:receptor internalization

0007165:signal transduction

0048208:COPII vesicle coating

0012507:ER to Golgi transport vesicle membrane

0030666:endocytic vesicle membrane

0099583:neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

0001540:amyloid-beta binding

0060292:long-term synaptic depression

PDB

6X5Q

Drugbank

DB00142 ; DB01236 ; DB01189 ; DB00237 ; DB00753 ; DB04982 ; DB09289 ; DB01028 ; DB05047 ; DB00555 ; DB08883 ; DB06247 ; DB13146 ; DB00898

KEGG

hsa:2890

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0714	Yan Tai Chai Hu	烟台柴胡	Chinese thorowax	Bupleurum chinense
H0685	Xuan Cao Gen	萱草根	Orange daylily	Hemerocallis fulva
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H1037	Fen Ge	粉葛	Thomson kudzuvine	Pueraria thomsonii
H0659	Chai Hu Jin Gao	柴胡浸膏	Chinese thorowax	Bupleurum chinense
H0650	Chai Hu	柴胡	Chinese thorowax	Bupleurum chinense
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0665	Chai Hu Shao	柴胡梢	Chinese thorowax	Bupleurum chinense
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 19)