Target Description

Type Detail
Target ID T51WML
Protein Name Glutamate receptor 1
Uniprot ID P42261
Protein Name Alias GluR-1;  AMPA-selective glutamate receptor 1;  GluR-A;  GluR-K1;  Glutamate receptor ionotropic, AMPA 1;  GluA1
Gene ID 2890
Gene Symbol GRIA1
Gene Alias GLUH1;  GLUR1
TTD T33584: Successful target
Pfam PF10613 ; PF00060 ; PF01094
GO
0006888:endoplasmic reticulum to Golgi vesicle-mediated transport

0008066:glutamate receptor activity

1904315:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

0005789:endoplasmic reticulum membrane

0009986:cell surface

0032591:dendritic spine membrane

0044309:neuron spine

0030425:dendrite

0032281:AMPA glutamate receptor complex

0038023:signaling receptor activity

0007268:chemical synaptic transmission

0043197:dendritic spine

0099061:integral component of postsynaptic density membrane

0055037:recycling endosome

2000310:regulation of NMDA receptor activity

0043025:neuronal cell body

0033116:endoplasmic reticulum-Golgi intermediate compartment membrane

0060076:excitatory synapse

0099544:perisynaptic space

0055038:recycling endosome membrane

0030165:PDZ domain binding

0015276:ligand-gated ion channel activity

0071242:cellular response to ammonium ion

0097060:synaptic membrane

0044308:axonal spine

0031901:early endosome membrane

0005886:plasma membrane

0098978:glutamatergic synapse

0030672:synaptic vesicle membrane

0007616:long-term memory

0004971:AMPA glutamate receptor activity

0014069:postsynaptic density

0031623:receptor internalization

0007165:signal transduction

0048208:COPII vesicle coating

0012507:ER to Golgi transport vesicle membrane

0030666:endocytic vesicle membrane

0099583:neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

0001540:amyloid-beta binding

0060292:long-term synaptic depression

PDB 6X5Q
Drugbank DB00142 ; DB01236 ; DB01189 ; DB00237 ; DB00753 ; DB04982 ; DB09289 ; DB01028 ; DB05047 ; DB00555 ; DB08883 ; DB06247 ; DB13146 ; DB00898
KEGG hsa:2890

Related Compounds  (Total: 4)

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C0226
Name: Morphine
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C0337
Name: Puerarin
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C1027
Name: kainic acid
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C1115
Name: cocaine


Related Herbs  (Total: 19)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0756 Ying Su罂粟 Opium poppyPapaver somniferum
H0685 Xuan Cao Gen萱草根 Orange daylilyHemerocallis fulva
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H1037 Fen Ge粉葛 Thomson kudzuvinePueraria thomsonii
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis